scholarly journals 1091 Evaluation of the in vitro skin penetration of acyclovir cream through human cadaver skin

2018 ◽  
Vol 138 (5) ◽  
pp. S185
Author(s):  
M. Niu ◽  
B. Upadhyay ◽  
C. Yen ◽  
M. Germann
Keyword(s):  
Skin Penetration ◽  
Human Cadaver ◽  
Human Cadaver Skin ◽  
Cadaver Skin ◽  
In Vitro Skin Penetration ◽  
Acyclovir Cream

scholarly journals Effect of iron and silica nanoparticles’ size on in vitro human skin binding and penetration

2019 ◽  
Vol 3 ◽  
pp. 239784731989305 ◽  
Author(s):  
Eui Jung ◽  
Xiaoying Hui ◽  
Hanjiang Zhu ◽  
Alissa Zhang ◽  
Wei Wang ◽  
...  
Keyword(s):  
Binding Affinity ◽  
Chemical Properties ◽  
Skin Penetration ◽  
Skin Layer ◽  
Tape Stripping ◽  
Human Cadaver Skin ◽  
Stripping Method ◽  
Cadaver Skin ◽  
Flow Through

This in vitro skin study determined absorption, diffusion, and binding rates of four [14C]-labeled nanoparticles (NPs): 12 nm Fe3O4, 32 nm Fe3O4@SiO2, 33 nm SiO2, and 78 nm SiO2 in each layer of human cadaver skin. In vitro microdialysis device and flow-through skin diffusion system were used to measure the binding affinity to the stratum corneum (SC) and permeability into/through skin layer of the four NPs with different physical–chemical properties, respectively, in short (30 min) and/or long (24 hours) exposures. Results show that NP size is an important factor affecting NP percutaneous absorption. The 12 nm Fe3O4 NPs reached the SC and viable epidermis; 32 nm Fe3O4@SiO2 core/shell NPs only reached SC. However, 33 nm and 78 nm silica NPs did not permeate SC. Similar patterns were observed for NP binding affinity to SC and dermatopharmacokinetic analysis using the tape stripping method. The binding affinity determination may be a useful method to efficiently screen skin penetration of NPs.

scholarly journals Thymoquinone-Loaded Polymeric Films and Hydrogels for Bacterial Disinfection and Wound Healing

Biomedicines ◽  
2020 ◽  
Vol 8 (10) ◽  
pp. 386
Author(s):  
Anika Haq ◽  
Suneel Kumar ◽  
Yong Mao ◽  
Francois Berthiaume ◽  
Bozena Michniak-Kohn
Keyword(s):  
Staphylococcus Aureus ◽  
Wound Healing ◽  
Wound Infection ◽  
Skin Permeation ◽  
Control Group ◽  
Significant Activity ◽  
Human Cadaver ◽  
Human Cadaver Skin ◽  
Cadaver Skin

The purpose of this study was to synthesize and characterize novel biocompatible topical polymeric film and hydrogel systems that have the potential to deliver the antibacterial agent thymoquinone (TQ) directly to the skin target site to manage the local wound infection and thereby wound healing. The polyvinyl pyrrolidone (PVP) matrix-type films containing TQ were prepared by the solvent casting method. In vitro skin permeation studies on human cadaver skin produced a mean flux of 2.3 µg TQ/cm2/h. Human keratinocyte monolayers subjected to a scratch wound (an in vitro wound healing assay) showed 85% wound closure at day 6 in the TQ group (100 ng/mL TQ) as compared to 50% in the vehicle control group (p = 0.0001). In a zone-of-inhibition (ZOI) assay, TQ-containing films and hydrogels completely wiped out Staphylococcus aureus in 10 cm diameter Tryptic Soy Agar plates while 500 µg/mL gentamicin containing filters gave 10 mm of ZOI. In an ex vivo model, TQ-containing films eradicated bacterial colonization on human cadaver skin. Furthermore, in a full-thickness wound infection model in mice, TQ-containing films showed significant activity in controlling Staphylococcus aureus infection, thereby disinfecting the skin wound. In summary, TQ-containing PVP films and hydrogels developed in this study have the potential to treat and manage wound infections.

scholarly journals Alfuzosin hydrochloride transdermal films: evaluation of physicochemical, in vitro human cadaver skin permeation and thermodynamic parameters

2009 ◽  
Vol 35 (6) ◽  
pp. 716-729 ◽  
Author(s):  
Satyanarayan Pattnaik ◽  
Swain Kalpana ◽  
Parthagan Choudhury ◽  
Pradeepta K. Acharya ◽  
Subrata Mallick
Keyword(s):  
Thermodynamic Parameters ◽  
Skin Permeation ◽  
Human Cadaver ◽  
Human Cadaver Skin ◽  
Cadaver Skin ◽  
Alfuzosin Hydrochloride

Human Cadaver Skin Viability for In Vitro Percutaneous Absorption

2005 ◽  
pp. 311-316
Author(s):  
Nicholas Poblete ◽  
Ronald Wester ◽  
James Forsell ◽  
Tracy Hartway ◽  
Julie Christoffel ◽  
...  
Keyword(s):  
Percutaneous Absorption ◽  
Human Cadaver ◽  
Human Cadaver Skin ◽  
Cadaver Skin ◽  
In Vitro Percutaneous Absorption

Effect of Polyethlene Glycol 400 on the Penetration of Drugs Through Human Cadaver Skin In Vitro

1986 ◽  
Vol 75 (1) ◽  
pp. 26-28 ◽  
Author(s):  
Pramod P. Sarpotdar ◽  
James L. Gaskill ◽  
Robert P. Giannini
Keyword(s):  
Human Cadaver ◽  
Human Cadaver Skin ◽  
Cadaver Skin

Immunogenicity of Glycerol-Preserved Human Cadaver Skin In Vitro

1997 ◽  
Vol 18 (3) ◽  
pp. 228-233 ◽  
Author(s):  
C D Richters ◽  
M J Hoekstra ◽  
J van Baare ◽  
J S du Pont ◽  
E W A Kamperdijk
Keyword(s):  
Human Cadaver ◽  
Human Cadaver Skin ◽  
Cadaver Skin

Human Cadaver Skin Viability for In Vitro Percutaneous Absorption

2021 ◽  
pp. 725-730
Author(s):  
Ronald C. Wester ◽  
Julie Christoffel ◽  
Tracy Hartway ◽  
Nicholas Poblete ◽  
Howard I. Maibach ◽  
...  
Keyword(s):  
Percutaneous Absorption ◽  
Human Cadaver ◽  
Human Cadaver Skin ◽  
Cadaver Skin ◽  
In Vitro Percutaneous Absorption
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