scholarly journals 520 Body site heterogeneity and microbial diversity is lost in individuals with hidradenitis suppurativa

2019 ◽  
Vol 139 (5) ◽  
pp. S89
Author(s):  
A. Schneider ◽  
L. Cook ◽  
X. Zhan ◽  
K. Banerjee ◽  
Z. Cong ◽  
...  
2020 ◽  
Vol 140 (3) ◽  
pp. 716-720 ◽  
Author(s):  
Andrea M. Schneider ◽  
Lauren C. Cook ◽  
Xiang Zhan ◽  
Kalins Banerjee ◽  
Zhaoyuan Cong ◽  
...  

2019 ◽  
Author(s):  
Andrea M. Schneider ◽  
Lauren C. Cook ◽  
Xiang Zhan ◽  
Kalins Banerjee ◽  
Zhaoyuan Cong ◽  
...  

ABSTRACTHidradenitis Suppurativa (HS) is a chronic, scarring, inflammatory skin disease affecting hair follicles in axillae, inguinal, and anogenital regions. Dysbiosis in HS patients compared to healthy subjects is documented. However, whether dysbiosis is specific to particular body sites or skin niches is unknown. We investigated the follicular and skin surface microbiome of the axilla and groin of HS patients (n=11) and healthy individuals (n=10) using 16S rRNA gene sequencing (V3-V4). We sampled non-lesional (HSN) and lesional skin (HSL) of HS patients. β-diversity was significantly decreased (p<0.05) in HSN and HSL skin compared to normal skin with loss of body site and skin niche heterogeneity in HS samples. The relative bacterial abundance of specific microbes was also significantly different between normal and HSN (15 genera) or HSL (21 genera) skin. Smoking and alcohol use influenced the β-diversity (p<0.08) in HS skin. We investigated metabolic profiles of bacterial communities in HS and normal skin using a computational approach.Metabolism, Genetic Information Processing, andEnvironmental Information Processingwere significantly different between normal and HS samples. Altered metabolic pathways associated with dysbiosis of HS skin suggest mechanisms underlying the disease pathology and information about treatment with drugs targeting those pathways.


2004 ◽  
Vol 30 (08/09) ◽  
Author(s):  
S Valiukeviciene ◽  
I Miseviciene ◽  
H Gollnick

2020 ◽  
Vol 99 (9) ◽  

Introduction: Perianal hidradenitis suppurativa is a chronic recurrent inflammatory, suppurative, and fistulising disease of apocrine glands, adjacent anal canal and soft tissues. Perianal area is the second most common affected area after axilla. There are three grades of the disease. Hidradenitis suppurativa represents a chronic, recurrent, deep-seated folliculitis resulting in abscesses, followed by the formation of sinus tracts and subsequent scarring. Perianal hidradenitis suppurativa is the last and the most serious grade of the disease and a specific access is needed for patient preparation and surgical treatment alone. The currently preferred method of treatment for patients with extensive perianal hidradentitis is excision and closure with combination of skin flaps, primary suture and skin graft in one or two stages. Case reports: There are three case reports of perianal hidradenitis suppurativa in this article. The local and overall initial treatment of patients followed by a radical excision and closure with a rotation skin flaps and skin grafts is described. The final results were satisfactory, with no recurrence or serious complication.


Sign in / Sign up

Export Citation Format

Share Document