The role of depilation and deodorants in hidradenitis suppurativa

1982 ◽  
Vol 118 (2) ◽  
pp. 101-102 ◽  
Author(s):  
W. P. Morgan
Keyword(s):  
Hidradenitis Suppurativa

The role of bacterial colonization in the pathophysiology of hidradenitis suppurativa

Infectio ro ◽  
2018 ◽  
Vol 1 (53) ◽  
pp. 5
Author(s):  
Bogdan Dima ◽  
Mara Mădălina Mihai ◽  
Gabriela-Loredana Popa ◽  
Monica Beatrice Dima ◽  
Olguţa Anca Orzan
Keyword(s):  
Hidradenitis Suppurativa ◽  
Bacterial Colonization

Serum Concentration and Skin Expression of S100A7 (Psoriasin) in Patients Suffering from Hidradenitis Suppurativa

Dermatology ◽  
2020 ◽  
pp. 1-7
Author(s):  
Aleksandra Batycka-Baran ◽  
Wojciech Baran ◽  
Danuta Nowicka-Suszko ◽  
Maria Koziol-Gałczyńska ◽  
Andrzej Bieniek ◽  
...  
Keyword(s):  
Serum Concentration ◽  
Hidradenitis Suppurativa ◽  
Protein Concentration ◽  
Normal Skin ◽  
Innate Immune ◽  
Antimicrobial Protein ◽  
Healthy Controls ◽  
Serum Concentrations ◽  
Reactive Protein

<b><i>Background:</i></b> Hidradenitis suppurativa (HS) is a chronic inflammatory skin disease. An important role of innate immune dysregulation in the pathogenesis of HS has been highlighted. S100A7 (psoriasin) is an innate, antimicrobial protein that exerts proinflammatory and chemotactic action. <b><i>Objectives:</i></b> The objective of the study was to investigate serum concentrations of S100A7 in individuals with HS as compared to healthy controls. Further, we evaluated the expression of S100A7 in lesional HS skin as compared to perilesional (clinically uninvolved) HS skin and normal skin. <b><i>Methods:</i></b> Serum concentrations of S100A7 were evaluated with a commercially available ELISA kit. The expression of S100A7 in the skin was assessed using qRT-PCR and immunofluorescence staining. <b><i>Results:</i></b> We found increased expression of S100A7 in lesional HS skin as compared to perilesional HS skin (<i>p</i> = 0.0017). The expression of S100A7 in lesional HS skin was positively associated with serum C-reactive protein concentration and the severity of disease according to Hurley staging. The serum concentration of S100A7 in individuals with HS was decreased as compared to healthy controls and patients with psoriasis. <b><i>Conclusions:</i></b> Upregulated in lesional HS skin, S100A7 may enhance the inflammatory process and contribute to the HS pathogenesis.

Objective scoring of hidradenitis suppurativa reflecting the role of tobacco smoking and obesity

2009 ◽  
Vol 161 (4) ◽  
pp. 831-839 ◽  
Author(s):  
K. Sartorius ◽  
L. Emtestam ◽  
G.B.E. Jemec ◽  
J. Lapins
Keyword(s):  
Tobacco Smoking ◽  
Hidradenitis Suppurativa

scholarly journals 411 A new T helper 17 cytokine in hidradenitis suppurativa: antimicrobial and pro-inflammatory role of IL-26

2019 ◽  
Vol 139 (9) ◽  
pp. S285
Author(s):  
E. Scala ◽  
R. Di Caprio ◽  
S. Cacciapuoti ◽  
G. Caiazzo ◽  
A. Fusco ◽  
...  
Keyword(s):  
Hidradenitis Suppurativa ◽  
T Helper ◽  
T Helper 17

scholarly journals Cutaneous Effects of Notch Inhibitor Therapy: A Report of Two Cases

2020 ◽  
Vol 2020 ◽  
pp. 1-4
Author(s):  
Claire J. Wiggins ◽  
Susan Y. Chon
Keyword(s):  
Side Effects ◽  
Notch Signaling ◽  
Hidradenitis Suppurativa ◽  
Disease Pathogenesis ◽  
Cutaneous Side Effects ◽  
Medication Side Effects ◽  
Medication Side ◽  
Notch Pathways ◽  
Inhibitor Treatment

As aberrant Notch signaling has been linked to cancerous growth, Notch inhibitors represent a novel category of targeted oncological therapy. Notch pathways in tumor cells may contribute to proliferation or limit apoptosis and differentiation. Healthy skin differentiation and homeostasis are reliant on normal Notch expression, and disruption of this signaling has been implicated in dermatological conditions such as hidradenitis suppurativa, psoriasis, atopic dermatitis, and lichen planus. Here, we describe two cases of patients with cutaneous side effects from Notch inhibitor treatment for adenoid cyst carcinoma (ACC) and review the role of Notch signaling in skin disease. By illuminating connections between medication side effects and disease pathogenesis, our goal is to increase awareness of the cutaneous side effects of Notch inhibitor treatment.

scholarly journals Clinical Role of Modified Seton Procedure and Coring Out for Treatment of Complex Anal Fistulas Associated With Hidradenitis Suppurativa

2015 ◽  
Vol 100 (6) ◽  
pp. 974-978
Author(s):  
Yukihiko Tokunaga ◽  
Hirokazu Sasaki
Keyword(s):  
Hidradenitis Suppurativa ◽  
Fecal Continence ◽  
Purulent Discharge ◽  
Fistula Tract ◽  
Surgical Operation ◽  
Anal Fistulas ◽  
Clinical Role ◽  
Complex Anal Fistulas

A variety of techniques have been described to treat complex anal fistulas. When complex anal fistulas are associated with hidradenitis suppurativa, the treatment has to be appropriately tailored for the severity and distribution of the disease so as to remove the external fistula tract to prevent recurrence while ensuring fecal continence. Between 2007 and 2011, a total of 10 males (ranging in age from 32 to 54 years) complained of recurrent purulent discharge in the buttocks and thigh regions. The discharge had started about 12 to 18 months prior, and had increased progressively resulting in complex anal fistulas and hidradenitis suppurativa in the buttocks. They underwent surgical operation according to a modified seton procedure for complex anal fistulas and coring out for hidradenitis suppurativa. They were discharged from the hospital in 4 to 5 days, while the seton dropped spontaneously about 6 to 8 months after surgery. They have been well without any morbidities or recurrence. The present paper demonstrates that cases of complex anal fistulas associated with hidradenitis suppurativa can be successfully treated with a modified seton procedure and coring out of hidradenitis suppurativa.

scholarly journals Inherent differences in keratinocyte function in hidradenitis suppurativa: Evidence for the role of IL-22 in disease pathogenesis

2017 ◽  
Vol 47 (1) ◽  
pp. 57-70 ◽  
Author(s):  
Derek Jones ◽  
Anirban Banerjee ◽  
Peter Z. Berger ◽  
Alexandra Gross ◽  
Sean McNish ◽  
...  
Keyword(s):  
Hidradenitis Suppurativa ◽  
Disease Pathogenesis
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