Angiotensin-converting enzyme insertion/deletion polymorphism and the risk of ischemic stroke in a South Indian population

2008 ◽  
Vol 272 (1-2) ◽  
pp. 132-135 ◽  
Author(s):  
Anjana Munshi ◽  
Shehnaz Sultana ◽  
Subhash Kaul ◽  
B. Pulla Reddy ◽  
Suvarna Alladi ◽  
...  
Keyword(s):  
Ischemic Stroke ◽  
Angiotensin Converting Enzyme ◽  
Indian Population ◽  
South Indian Population ◽  
Converting Enzyme ◽  
Deletion Polymorphism ◽  
South Indian

scholarly journals Angiotensin-Converting Enzyme Gene Insertion/Deletion Polymorphism and Small Vessel Cerebral Stroke in Indian Population

2014 ◽  
Vol 2014 ◽  
pp. 1-4 ◽  
Author(s):  
Puttachandra Prabhakar ◽  
Tanima De ◽  
Dindagur Nagaraja ◽  
Rita Christopher
Keyword(s):  
Blood Pressure ◽  
Angiotensin Converting Enzyme ◽  
Indian Population ◽  
Fold Increase ◽  
Small Vessel ◽  
Cerebral Stroke ◽  
South Indian Population ◽  
Converting Enzyme ◽  
Gene Insertion ◽  
South Indian

Background. Hypertension is an established risk factor for small-vessel cerebral stroke and the renin-angiotensin system plays an important role in the maintenance of blood pressure. We aimed at evaluating the contribution of the angiotensin-converting enzyme (ACE) gene insertion/deletion (I/D) polymorphism to the risk of small-vessel stroke in south Indian population.Materials and Methods. We investigated 128 patients diagnosed with small-vessel stroke and 236 age, and gender-matched healthy controls.ACEI/D polymorphism was detected by polymerase chain reaction.Results. Hypertension was significantly more prevalent in the patient group and was associated with 6-fold increase in risk for stroke.ACEgenotypes were in Hardy-Weinberg equilibrium in both patients and controls. Prevalence of DD, ID, and II genotypes in cases (34.4%, 43.7%, and 28%) did not differ significantly from controls (31.8%, 43.2%, and 25%). The polymorphism was not associated with small-vessel stroke (OR: 1.34; 95% CI: 0.52–1.55). However, diastolic blood pressure was associated with theACEI/D genotypes in the patients. (DD;90.2±14.2>ID;86.2±11.9>II;82.3±7.8 mm Hg,  P=0.047).Conclusion. Our study showed that hypertension, but notACEI/D polymorphism, increased the risk of small-vessel stroke.

VNTR polymorphism in intron 4 of the eNOS gene and the risk of ischemic stroke in a South Indian population

2010 ◽  
Vol 82 (5-6) ◽  
pp. 247-250 ◽  
Author(s):  
Anjana Munshi ◽  
K. Rajeshwar ◽  
Subhash Kaul ◽  
E. Chandana ◽  
Gowhar Shafi ◽  
...  
Keyword(s):  
Ischemic Stroke ◽  
Indian Population ◽  
Enos Gene ◽  
South Indian Population ◽  
Vntr Polymorphism ◽  
South Indian ◽  
Intron 4

Deletion polymorphism in the angiotensin-converting enzyme gene in patients with a history of ischemic stroke

1995 ◽  
Vol 115 ◽  
pp. S79
Author(s):  
M. Margaglione ◽  
G. Di Minno ◽  
E. Grandone ◽  
G. Vecchione ◽  
E. Celentano ◽  
...  
Keyword(s):  
Ischemic Stroke ◽  
Angiotensin Converting Enzyme ◽  
Angiotensin Converting Enzyme Gene ◽  
Converting Enzyme ◽  
Deletion Polymorphism ◽  
Enzyme Gene ◽  
History Of

Phosphodiesterase 4D (PDE4D) gene variants and the risk of ischemic stroke in a South Indian population

2009 ◽  
Vol 285 (1-2) ◽  
pp. 142-145 ◽  
Author(s):  
Anjana Munshi ◽  
M Sai Babu ◽  
Subhash Kaul ◽  
Gowhar Shafi ◽  
A.N. Anila ◽  
...  
Keyword(s):  
Ischemic Stroke ◽  
Indian Population ◽  
South Indian Population ◽  
Gene Variants ◽  
South Indian ◽  
Phosphodiesterase 4D
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