scholarly journals Donor sex and age influence the chondrogenic potential of human femoral bone marrow stem cells

2010 ◽  
Vol 18 (5) ◽  
pp. 705-713 ◽  
Author(s):  
K.A. Payne ◽  
D.M. Didiano ◽  
C.R. Chu
Keyword(s):  
Stem Cells ◽  
Bone Marrow ◽  
Bone Marrow Stem Cells ◽  
Femoral Bone ◽  
Chondrogenic Potential ◽  
Femoral Bone Marrow

scholarly journals Effect of a combination of TGFβ and IGF growth factors on the chondrogenic potential of mesenchymal bone marrow stem cells

2021 ◽  
Vol 2 (216) ◽  
pp. 78-83
Author(s):  
Anna Zhernosechenko ◽  
◽  
Yanina Isaykina ◽  
Tatiana Filipovich
Keyword(s):  
Gene Expression ◽  
Stem Cells ◽  
Bone Marrow ◽  
Growth Factors ◽  
Chondrogenic Differentiation ◽  
Bone Marrow Stem Cells ◽  
Suppression Effect ◽  
Chondrogenic Potential ◽  
2D And 3D

The authors studied the influence of the combination of TGF? and IGF growth factors, as well as the differentiation time, on the induction of MSC chondrogenesis in vitro. It is proved that MSCs located in 2D and 3D systems, when exposed to TGF?/ IGF, showed the signs of early chondroblast-like cells in 7 days. The TGF?/ IGF used for the induction of MSCs is more preferred, because it results in a more pronounced hypertrophic-suppression effect. The absence of significant differences in gene expression (excepting Sox9) on the 7th and 21st days of chondrogenic differentiation allows the process to be reduced in vitro to 7 days.

scholarly journals Decline in the growth potential of spleen-colonizing bone marrow stem cells of long-lived aging mice.

1976 ◽  
Vol 144 (5) ◽  
pp. 1204-1213 ◽  
Author(s):  
J W Albright ◽  
T Makinodan
Keyword(s):  
Stem Cells ◽  
Bone Marrow ◽  
Extended Period ◽  
Colony Growth ◽  
Bone Marrow Stem Cells ◽  
Growth Potential ◽  
Growth Capacity ◽  
Additional Reduction ◽  
Femoral Bone Marrow ◽  
Intrinsic Characteristic

The growth capacity of femoral bone marrow stem cells from young and old long-lived mice was assessed in the spleen of X-irradiated young and old syngeneic recpients by determining: (a) the number of stem cells colonizing the spleen, (b) the rate of incorporation of 125I-labeled iododeoxyuridine by proliferating colony cells, and (c) the number of cells present in the largest colonies at the end of the growth phase.We found that the growth capacity of stem cells declined with age. We further found that the spleen-seeking and spleen colony growth capacities of old stem cells remained characteristically old even after they were allowed to self-replicate in the bone marrow of young recipients for an extended period of time. On the other hand, the spleen colony growth capacity of young stem cells could be reduced by allowing them to self-replicate in old recipients. These results suggest that the growth capacity of old stem cells is an intrinsic characteristic which cannot be readily altered, but that of young stem cells can be aged in an accelerated manner by allowing them to self-replicate in old recipients. An additional reduction was noted in the frequency of both young and old stem cells colonizing the spleen of old recipients and in the cell density of the largest colonies produced. These results indicate that factors extrinsic to the stem cells are also responsible for the decline with age in their spleen colony growth capacity.Thus, the growth capacity of old stem cells in old recipients could be as low as 10% that of young stem cells in young recipients.

scholarly journals Multipotential Mesenchymal Stem Cells from Femoral Bone Marrow Near the Site of Osteonecrosis

Stem Cells ◽  
2003 ◽  
Vol 21 (2) ◽  
pp. 190-199 ◽  
Author(s):  
Hsuan-Shu Lee ◽  
Guan-Tarn Huang ◽  
Hongsen Chiang ◽  
Ling-Ling Chiou ◽  
Min-Huey Chen ◽  
...  
Keyword(s):  
Stem Cells ◽  
Bone Marrow ◽  
Mesenchymal Stem Cells ◽  
Femoral Bone ◽  
Femoral Bone Marrow

Bone marrow stem cells make hepatocytes with replicative potential

2001 ◽  
Vol 120 (5) ◽  
pp. A62-A62
Author(s):  
S FORBES ◽  
M ALISON ◽  
K HODIVALADILKE ◽  
R JEFFERY ◽  
R POULSOM ◽  
...  
Keyword(s):  
Stem Cells ◽  
Bone Marrow ◽  
Bone Marrow Stem Cells

Autologous 5-azacytidine-cultured bone-marrow stem cells in surgical treatment of heart failure

2008 ◽  
Vol 7 ◽  
pp. 114-115
Author(s):  
R AKCHURIN ◽  
T RAKHMATZADE ◽  
E SKRIDLEVSKAYA ◽  
L SAMOYLENKO ◽  
V SERGIENKO ◽  
...  
Keyword(s):  
Heart Failure ◽  
Stem Cells ◽  
Bone Marrow ◽  
Surgical Treatment ◽  
Bone Marrow Stem Cells
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