Hemostatic markers and platelet aggregation factors as predictive markers for type of stroke and neurological disability following cerebral infarction

The binding of platelet glycoprotein (GP) IIb/IIIa to fibrinogen is the final common pathway in platelet aggregation, a process known to play a key role in the pathogenesis of ischemic brain damage. We compared the effects of FK419, a novel nonpeptide GPIIb/IIIa antagonist, with recombinant tissue plasminogen activator (rt-PA) on middle cerebral artery (MCA) patency and ischemic brain damage in a thrombotic stroke model in squirrel monkeys. FK419 not only inhibited in vitro platelet aggregation (IC50: 88 nmol/L), but also showed disaggregatory activity to aggregated platelet (EC50: 286 nmol/L). FK419 dose-dependently reduced the time to first reperfusion and total occlusion time of MCA blood flow when administered immediately after the termination of photoirradiation. FK419 reduced cerebral infarction and ameliorated neurologic deficits with similar dose-dependency. Although rt-PA reduced the time to first reperfusion, total occlusion time, and cerebral infarction, it did not significantly ameliorate neurologic deficits and induced petechial intracerebral hemorrhages. These results indicate: (1) FK419 restored cerebral blood flow after thrombotic occlusion of MCA, (2) FK419 reduced ischemic brain injury by its thrombolytic actions in a non-human primate stroke model, and (3) FK419 has superior antithrombotic efficacy and is safer than rt-PA.

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Eicosapentaenoic and Docosahexaenoic Acid Supplementations Reduce Platelet Aggregation and Hemostatic Markers Differentially in Men and Women

Journal of Nutrition ◽

10.3945/jn.112.171249 ◽

2013 ◽

Vol 143 (4) ◽

pp. 457-463 ◽

Cited By ~ 43

Author(s):

Melinda Phang ◽

Lisa F. Lincz ◽

Manohar L. Garg

Keyword(s):

Platelet Aggregation ◽

Docosahexaenoic Acid ◽

Men And Women ◽

Reduce Platelet Aggregation ◽

Hemostatic Markers

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Association of Recurrent Cerebral Infarction With Adenosine Diphosphate– and Collagen-Induced Platelet Aggregation in Patients Treated With Ticlopidine and/or Aspirin

Journal of Stroke and Cerebrovascular Diseases ◽

10.1016/j.jstrokecerebrovasdis.2010.01.013 ◽

2011 ◽

Vol 20 (4) ◽

pp. 319-323 ◽

Cited By ~ 2

Author(s):

Takeo Abumiya ◽

Kiyohiro Houkin

Keyword(s):

Platelet Aggregation ◽

Cerebral Infarction ◽

Adenosine Diphosphate

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Measurement of spontaneous platelet aggregation in patients with acute cerebral infarction using laser-scattered light aggregometry

Nosotchu ◽

10.3995/jstroke.26.364 ◽

2004 ◽

Vol 26 (2) ◽

pp. 364-370

Author(s):

Koji Yamada ◽

Toshikazu Hirayama ◽

Hiroshi Sugihara ◽

Naoko Yazaki ◽

Youichi Takahashi ◽

...

Keyword(s):

Platelet Aggregation ◽

Cerebral Infarction ◽

Scattered Light ◽

Acute Cerebral Infarction ◽

Spontaneous Platelet Aggregation

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Spontaneous Platelet Aggregation in Cerebrovascular Disease

Thrombosis and Haemostasis ◽

10.1055/s-0038-1646673 ◽

1978 ◽

Vol 39 (01) ◽

pp. 223-229 ◽

Cited By ~ 45

Author(s):

J W Ten Cate ◽

J Vos ◽

H Oosterhuis ◽

D Prenger ◽

C S P Jenkins

Keyword(s):

Platelet Aggregation ◽

Cerebral Infarction ◽

Clinical Symptoms ◽

Divalent Cations ◽

Normal Subjects ◽

Transient Ischaemic Attacks ◽

Refractory State ◽

Spontaneous Platelet Aggregation ◽

Aggregation Tendency

Summary50 patients from a group of 130 patients with transient ischaemic attacks or cerebral infarction were found to demonstrate in vitro spontaneous platelet aggregation (SPA) while 80 normal subjects tested never showed this phenomenon.The following additional findings point towards a possible platelet abnormality:1. Platelets from 10 patients with SPA when isolated and resuspended in normal plasma still demonstrated SPA while isolated normal platelets resuspended in patient’s plasma did not.2. Platelets demonstrating SPA showed an increased aggregation tendency upon incubation with ADP while normal platelets developed the expected refractory state.SPA was found to be dependant upon the presence of divalent cations and could further be inhibited by phentolamine and adenosine. Aspirin effectively abolished SPA in 50 patients and relieved the clinical symptoms of patients with recurrent complaints of transient blindness and paraesthesia.

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