Color vision testing versus pattern visual evoked potentials and optical coherence tomography parameters in subclinical optic nerve involvement in multiple sclerosis

Background: Diagnosis of multiple sclerosis (MS) may sometimes be ascertained at the time of optic neuritis (ON) but other times require the advent of new disease activity. Objectives: The aim of this study was to examine the predictive value of optical coherence tomography (OCT) and visual evoked potential (VEP) measurements of the non-symptomatic, fellow eye of ON patients, for conversion to MS. Methods: This is a prospective cohort study in patients with acute ON. OCT thickness measurements of peripapillary retinal nerve fiber layer (pRNFL) and macular ganglion cell layer–inner plexiform layer (GCLIPL), and multifocal (mf) VEP and full-field (ff) VEP, were performed. Univariate and multivariate Cox regression examined the value of predictors for the conversion to MS. Results: A total of 79 unilateral, acute ON patients, with no MS diagnosis or prior demyelination, were included. Of which, 28 patients developed MS during follow-up. Inferonasal GCLIPL, mean GCLIPL, and pRNFL thickness significantly predicted MS development in multivariate analysis (hazard ratio (HR) = 0.922–0.939, p = 0.0172–0.021). MfVEP mean latency (HR = 1.052, p = 0.006) only predicted MS conversion in univariate analysis. No significant predictive value was shown for the other parameters ( p > 0.2). Conclusion: While both mfVEP and OCT are useful tools in the evaluation of acute ON patients, only OCT measurements of fellow eyes may serve as an independent predictor of MS development.

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Assessment of structural and functıonal vısual outcomes ın relapsıng remıttıng multıple sclerosıs wıth vısual evoked potentıals and optıcal coherence tomography

Journal of the Neurological Sciences ◽

10.1016/j.jns.2013.09.027 ◽

2013 ◽

Vol 335 (1-2) ◽

pp. 182-185 ◽

Cited By ~ 14

Author(s):

Betul Tugcu ◽

Aysun Soysal ◽

Murat Kılıc ◽

Burcu Yuksel ◽

Nılufer Kale ◽

...

Keyword(s):

Multiple Sclerosis ◽

Optical Coherence Tomography ◽

Evoked Potentials ◽

Visual Evoked Potentials ◽

Optical Coherence ◽

Visual Outcomes ◽

Relapsing Remitting ◽

Remitting Multiple Sclerosis ◽

Relapsing Remitting Multiple Sclerosis ◽

Visual Evoked

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Sensitivity of visual evoked potentials and spectral domain optical coherence tomography in early relapsing remitting multiple sclerosis

Multiple Sclerosis and Related Disorders ◽

10.1016/j.msard.2016.12.005 ◽

2017 ◽

Vol 12 ◽

pp. 15-19 ◽

Cited By ~ 4

Author(s):

Raed Behbehani ◽

Samar Ahmed ◽

Jasem Al-Hashel ◽

Rossen T. Rousseff ◽

Raed Alroughani

Keyword(s):

Multiple Sclerosis ◽

Optical Coherence Tomography ◽

Evoked Potentials ◽

Visual Evoked Potentials ◽

Spectral Domain ◽

Optical Coherence ◽

Relapsing Remitting ◽

Remitting Multiple Sclerosis ◽

Relapsing Remitting Multiple Sclerosis ◽

Visual Evoked

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Optical coherence tomography for detection of asymptomatic optic nerve lesions in clinically isolated syndrome

Neurology ◽

10.1212/wnl.0000000000009832 ◽

2020 ◽

Vol 95 (6) ◽

pp. e733-e744 ◽

Cited By ~ 1

Author(s):

Olivier Outteryck ◽

Renaud Lopes ◽

Élodie Drumez ◽

Julien Labreuche ◽

Julien Lannoy ◽

...

Keyword(s):

Optical Coherence Tomography ◽

Optic Nerve ◽

Clinically Isolated Syndrome ◽

Nerve Lesion ◽

Inner Plexiform Layer ◽

Optical Coherence ◽

Optic Nerves ◽

Nerve Lesions ◽

Nerve Involvement ◽

Optic Nerve Involvement

ObjectiveTo evaluate the ability of intereye retinal thickness difference (IETD) measured by optical coherence tomography (OCT) to detect asymptomatic optic nerve involvement in clinically isolated syndrome (CIS).MethodsWe conducted a cross-sectional study of patients who recently presented a CIS (≤4.5 months). All patients underwent OCT and brain/optic nerve MRI. Optic nerve involvement was defined clinically (episode of optic neuritis [ON] or not) and radiologically (optic nerve hypersignal on 3D double inversion recovery [3D-DIR]). We evaluated the sensitivity and specificity of previously published IETD thresholds and report the observed optimal thresholds for identifying symptomatic optic nerve involvement but also for identifying asymptomatic optic nerve involvement (optic nerve hypersignal without ON history). Primary outcomes were ganglion cell–inner plexiform layer (GC-IPL) and peripapillary retinal nerve fiber layer IETD.ResultsThe study group consisted of 130 patients. In the CIS with ON group, 3D-DIR showed a hypersignal in all 41 symptomatic optic nerves and in 11 asymptomatic optic nerves. In the CIS without ON group, 3D-DIR showed a unilateral optic nerve hypersignal in 22 patients and a bilateral optic nerve hypersignal in 7 patients. For the detection of symptomatic and asymptomatic optic nerve lesion, GC-IPL IETD had better performance. We found an optimal GC-IPL IETD threshold ≥2.83 µm (sensitivity 88.2, specificity 83.3%) for the detection of symptomatic lesions and an optimal GC-IPL IETD ≥1.42 µm (sensitivity 89.3%, specificity 72.6%) for the detection of asymptomatic lesions.ConclusionsDetection of asymptomatic optic nerve lesions in CIS requires lower IETD thresholds than previously reported. GC-IPL IETD represents an alternative biomarker to MRI for the detection of asymptomatic optic nerve lesions.Classification of evidenceThis study provides Class I evidence that OCT accurately identifies asymptomatic optic nerve involvement in patients with CIS.

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