Differences in clinical outcomes between traumatic cervical myelopathy and degenerative cervical myelopathy: A comparative study of cervical spinal cord injury without major bone injury and cervical spondylotic myelopathy

2019 ◽  
Vol 70 ◽  
pp. 127-131
Author(s):  
Masaaki Machino ◽  
Kei Ando ◽  
Kazuyoshi Kobayashi ◽  
Masayoshi Morozumi ◽  
Satoshi Tanaka ◽  
...  
Keyword(s):  
Spinal Cord ◽  
Spinal Cord Injury ◽  
Comparative Study ◽  
Clinical Outcomes ◽  
Cervical Myelopathy ◽  
Cervical Spondylotic Myelopathy ◽  
Cervical Spinal Cord ◽  
Bone Injury ◽  
Cord Injury ◽  
Degenerative Cervical Myelopathy

scholarly journals Increasing awareness of degenerative cervical myelopathy: a preventative cause of non-traumatic spinal cord injury

Spinal Cord ◽  
2021 ◽  
Author(s):  
Carl M. Zipser ◽  
Konstantinos Margetis ◽  
Karlo M. Pedro ◽  
Armin Curt ◽  
Michael Fehlings ◽  
...  
Keyword(s):  
Spinal Cord ◽  
Spinal Cord Injury ◽  
Cervical Myelopathy ◽  
Cervical Spinal Cord ◽  
Neurological Impairment ◽  
Common Data Elements ◽  
Cord Injury ◽  
Data Elements ◽  
Degenerative Cervical Myelopathy ◽  
Work Up

AbstractDegenerative cervical myelopathy (DCM) is a common non-traumatic spinal cord disorder and characterized by progressive neurological impairment. Generally, it is still underdiagnosed and referral to spine specialists is often late, when patients already present with incomplete cervical spinal cord injury (SCI). To improve early diagnosis and accelerate referral, diagnostic criteria for DCM are required. Recently, AO Spine RECODE- DCM (REsearch Objectives and Common Data Elements for Degenerative Cervical Myelopathy) (aospine.org/recode), an international, interdisciplinary and interprofessional initiative, including patients with DCM, was funded with the aim to accelerate knowledge discovery that can change outcomes. In this perspective we advocate for the participation of SCI specialists in this process, where the expertise and perspective on this disorder and requirements for the diagnostic and therapeutic work up is well developed.

scholarly journals Clinical outcomes of late decompression surgery following cervical spinal cord injury with pre-existing cord compression

Spinal Cord ◽  
2017 ◽  
Vol 56 (4) ◽  
pp. 366-371
Author(s):  
Tsunehiko Konomi ◽  
Akimasa Yasuda ◽  
Kanehiro Fujiyoshi ◽  
Junichi Yamane ◽  
Shinjiro Kaneko ◽  
...  
Keyword(s):  
Spinal Cord ◽  
Spinal Cord Injury ◽  
Clinical Outcomes ◽  
Cervical Spinal Cord ◽  
Cord Compression ◽  
Cervical Spinal Cord Injury ◽  
Decompression Surgery ◽  
Cord Injury

scholarly journals The Natural History of Degenerative Cervical Myelopathy and the Rate of Hospitalization Following Spinal Cord Injury: An Updated Systematic Review

2017 ◽  
Vol 7 (3_suppl) ◽  
pp. 28S-34S ◽  
Author(s):  
Lindsay A. Tetreault ◽  
Spyridon Karadimas ◽  
Jefferson R. Wilson ◽  
Paul M. Arnold ◽  
Shekar Kurpad ◽  
...  
Keyword(s):  
Systematic Review ◽  
Spinal Cord ◽  
Spinal Cord Injury ◽  
Natural History ◽  
Cervical Myelopathy ◽  
Cochrane Collaboration ◽  
Level Of Evidence ◽  
Cord Injury ◽  
History Of ◽  
Degenerative Cervical Myelopathy

Study Method: Systematic review (update). Objective: Degenerative cervical myelopathy (DCM) is a degenerative spine disease and the most common cause of spinal cord dysfunction in adults worldwide. The objective of this study is to determine the natural history of DCM by updating the systematic review by Karadimas et al. The specific aims of this review were (1) to describe the natural history of DCM and (2) to determine potential risk factors of disease progression. Method: An updated search based on a previous protocol was conducted in PubMed and the Cochrane Collaboration library for studies published between November 2012 and February 15, 2015. Results: The updated search yielded 3 additional citations that met inclusion criteria and reported the incidence of spinal cord injury and severe disability in patients with DCM. Based on 2 retrospective cohort studies, the incidence rate of hospitalization for spinal cord injury is 13.9 per 1000 person-years in patients with cervical spondylotic myelopathy and 4.8 per 1000 person-years in patients with myelopathy secondary to ossification of the posterior longitudinal ligament (OPLL). In a third small prospective study, the risk of being wheelchair bound or bedridden was 66.7% in DCM patients with OPLL. Conclusion: The overall level of evidence for these estimated rates of hospitalization following spinal cord injury was rated as low.

Soft-Tissue Damage and Segmental Instability in Adult Patients With Cervical Spinal Cord Injury Without Major Bone Injury

Spine ◽  
2012 ◽  
Vol 37 (25) ◽  
pp. E1560-E1566 ◽  
Author(s):  
Takeshi Maeda ◽  
Takayoshi Ueta ◽  
Eiji Mori ◽  
Itaru Yugue ◽  
Osamu Kawano ◽  
...  
Keyword(s):  
Spinal Cord ◽  
Spinal Cord Injury ◽  
Soft Tissue ◽  
Tissue Damage ◽  
Cervical Spinal Cord ◽  
Cervical Spinal Cord Injury ◽  
Adult Patients ◽  
Segmental Instability ◽  
Bone Injury ◽  
Cord Injury

The Impact of Facet Dislocation on Clinical Outcomes After Cervical Spinal Cord Injury

Spine ◽  
2013 ◽  
Vol 38 (2) ◽  
pp. 97-103 ◽  
Author(s):  
Jefferson R. Wilson ◽  
Alexander Vaccaro ◽  
James S. Harrop ◽  
Bizhan Aarabi ◽  
Christopher Shaffrey ◽  
...  
Keyword(s):  
Spinal Cord ◽  
Spinal Cord Injury ◽  
Clinical Outcomes ◽  
Cervical Spinal Cord ◽  
Cervical Spinal Cord Injury ◽  
Facet Dislocation ◽  
Cord Injury ◽  
The Impact

Prospects of cell replacement therapy for the treatment of degenerative cervical myelopathy

2020 ◽  
Vol 0 (0) ◽  
Author(s):  
Graham Ka Hon Shea ◽  
Paul Aarne Koljonen ◽  
Ying Shing Chan ◽  
Kenneth Man Chee Cheung
Keyword(s):  
Spinal Cord ◽  
Spinal Cord Injury ◽  
Replacement Therapy ◽  
Cervical Myelopathy ◽  
Neurological Function ◽  
Traumatic Spinal Cord Injury ◽  
Cell Replacement Therapy ◽  
Cell Replacement ◽  
Cord Injury ◽  
Degenerative Cervical Myelopathy

AbstractDegenerative cervical myelopathy (DCM) presents insidiously during middle-age with deterioration in neurological function. It accounts for the most common cause of non-traumatic spinal cord injury in developed countries and disease prevalence is expected to rise with the aging population. Whilst surgery can prevent further deterioration, biological therapies may be required to restore neurological function in advanced disease. Cell replacement therapy has been inordinately focused on treatment of traumatic spinal cord injury yet holds immense promise in DCM. We build upon this thesis by reviewing the pathophysiology of DCM as revealed by cadaveric and molecular studies. Loss of oligodendrocytes and neurons occurs via apoptosis. The tissue microenvironment in DCM prior to end-stage disease is distinct from that following acute trauma, and in many ways more favourable to receiving exogenous cells. We highlight clinical considerations for cell replacement in DCM such as selection of cell type, timing and method of delivery, as well as biological treatment adjuncts. Critically, disease models often fail to mimic features of human pathology. We discuss directions for translational research towards clinical application.

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