Measuring the density of the fissula antefenestram and the section of the basal turn of the cochlea: are they useful in the radiological diagnosis of otosclerosis?

Abstract Background The EU gadolinium-based contrast agents (GBCA) market has changed in recent years due to the European Medicines Agency decision to suspend the marketing authorisation of linear GBCA and the marketing authorisation of new generic macrocyclic GBCA. The study aims to understand the patterns of (GBCA) use, and to study the effectiveness and safety of GBCA in routine practice across Europe. Methods Prospective, cross-sectional, multicentre, observational study in patients undergoing contrast-enhanced magnetic resonance. Reported usage patterns included indication, referral and examination details. Assessment of effectiveness included changes in radiological diagnosis, diagnostic confidence and image quality. Safety data were collected by spontaneous patient adverse event (AE) reporting. Results 2118 patients were included from 8 centres across 5 European countries between December 2018 and November 2019. Clariscan, Dotarem (gadoteric acid), Gadovist (gadobutrol) and ProHance (gadoteridol) were utilised in 1513 (71.4%), 356 (16.8%), 237 (11.2%) and 12 (0.6%) patients, respectively. Most were performed in CNS-related indications (46.2%). Mean GBCA doses were 0.10 mmol/kg body weight, except for Gadovist (mean 0.12 mmol/kg). GBCA use increased confidence in diagnosis in 96.2% of examinations and resulted in a change in radiological diagnosis in 73.9% of patients. Image quality was considered excellent or good in 96.1% of patients and across all GBCA. Four patients reported AEs (0.19%), with only 1 (0.05%) considered serious. Conclusions This European study confirmed that GBCAs are used appropriately in Europe for a wide range of indications. The study demonstrated a significant increase in diagnostic confidence after GBCA use and confirmed the good safety profile of GBCAs, with comparable results for all agents used.

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TUBERCULOSIS OF THE HIP IN CHILDREN: RADIOLOGICAL DIAGNOSIS

The Medical Journal of Australia ◽

10.5694/j.1326-5377.1962.tb20919.x ◽

1962 ◽

Vol 2 (21) ◽

pp. 840-841

Keyword(s):

Radiological Diagnosis

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A contribution to the radiological diagnosis and surgical treatment of necrotising enteritis of the newborn

Journal of Pediatric Surgery ◽

10.1016/0022-3468(67)90051-6 ◽

1967 ◽

Vol 2 (3) ◽

pp. 280

Author(s):

S. Hofmann ◽

H.B. Eckstein

Keyword(s):

Surgical Treatment ◽

Radiological Diagnosis

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An integrated patient oriented workstation for radiological diagnosis

Proceedings of the 15th Annual International Conference of the IEEE Engineering in Medicine and Biology Societ ◽

10.1109/iembs.1993.978456 ◽

2005 ◽

Author(s):

M. Gudmundsson ◽

M.R. Kabuka

Keyword(s):

Radiological Diagnosis

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Radiological Diagnosis of Pneumoconiosis

BMJ ◽

10.1136/bmj.1.4652.546-c ◽

1950 ◽

Vol 1 (4652) ◽

pp. 546-546

Author(s):

C. K. Robertson

Keyword(s):

Radiological Diagnosis

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Electron Microscopic Findings in Presbycusic Degeneration of the Basal Turn of the Human Cochlea

Otolaryngology ◽

10.1177/019459987908700617 ◽

1979 ◽

Vol 87 (6) ◽

pp. 818-836 ◽

Cited By ~ 47

Author(s):

Joseph B. Nadol

Keyword(s):

Light Microscopy ◽

Hair Cells ◽

Basilar Membrane ◽

Ganglion Cells ◽

Nerve Fibers ◽

Degenerative Changes ◽

Supporting Cells ◽

Neural Degeneration ◽

Basal Turn ◽

Temporal Bones

Three human temporal bones with presbycusis affecting the basal turn of the cochlea were studied by light and electron microscopy. Conditions in two ears examined by light microscopy were typical of primary neural degeneration, with a descending audiometric pattern, loss of cochlear neurons in the basal turn, and preservation of the organ of Corti. Ultrastructural analysis revealed normal hair cells and marked degenerative changes of the remaining neural fibers, especially in the basal turn. These changes included a decrease in the number of synapses at the base of hair cells, accumulation of cellular debris in the spiral bundles, abnormalities of the dendritic fibers and their sheaths in the osseous spiral lamina, and degenerative changes in the spiral ganglion cells and axons. These changes were interpreted as an intermediate stage of degeneration prior to total loss of nerve fibers and ganglion cells as visualized by light microscopy. In the third ear the changes observed were typical of primary degeneration of hair and supporting cells in the basal turn with secondary neural degeneration. Additional observations at an ultrastructural level included maintenance of the tight junctions of the scala media despite loss of both hair and supporting cells, suggesting a capacity for cellular “healing” in the inner ear. Degenerative changes were found in the remaining neural fibers in the osseous spiral lamina. In addition, there was marked thickening of the basilar membrane in the basal turn, which consisted of an increased number of fibrils and an accumulation of amorphous osmiophilic material in the basilar membrane. This finding supports the concept that mechanical alterations may occur in presbycusis of the basal turn.

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