Extent of physical, social and role activity limitations in Chronic Low Back Pain (CLBP) patients receiving opioid therapy: Results of an observational study

2005 ◽  
Vol 6 (3) ◽  
pp. S44
Author(s):  
M. Kosinski ◽  
J. Schein ◽  
S. Ascher ◽  
S. Vallow ◽  
C. Harte ◽  
...  
Keyword(s):  
Low Back Pain ◽  
Back Pain ◽  
Observational Study ◽  
Chronic Low Back Pain ◽  
Opioid Therapy ◽  
Activity Limitations ◽  
Low Back ◽  
Role Activity

scholarly journals Intervertebral disc therapies for non-specific chronic low back pain: a systematic review and meta-analysis

2021 ◽  
Vol 13 ◽  
pp. 1759720X2110280
Author(s):  
Camille Daste ◽  
Stéphanie Laclau ◽  
Margaux Boisson ◽  
François Segretin ◽  
Antoine Feydy ◽  
...  
Keyword(s):  
Systematic Review ◽  
Low Back Pain ◽  
Back Pain ◽  
Intervertebral Disc ◽  
Chronic Low Back Pain ◽  
Meta Analysis ◽  
Activity Limitations ◽  
Low Back ◽  
Short Term

Objectives: We aim to evaluate the benefits and harms of intervertebral disc therapies (IDTs) in people with non-specific chronic low back pain (NScLBP). Methods: We conducted a systematic review and meta-analysis of randomized trials of IDTs versus placebo interventions, active comparators or usual care. EMBASE, MEDLINE, CENTRAL and CINHAL databases and conference abstracts were searched from inception to June 2020. Two independent investigators extracted data. The primary outcome was LBP intensity at short term (1 week–3 months), intermediate term (3–6 months) and long term (after 6 months). Results: Of 18 eligible trials (among 1396 citations), five assessed glucocorticoids (GCs) IDTs and were included in a quantitative synthesis; 13 assessed other products including etanercept ( n = 2), tocilizumab ( n = 1), methylene blue ( n = 2), ozone ( n = 2), chymopapaine ( n = 1), glycerol ( n = 1), stem cells ( n = 1), platelet-rich plasma ( n = 1) and recombinant human growth and differentiation factor-5 ( n = 2), and were included in a narrative synthesis. Standardized mean differences (95% CI) for GC IDTs for LBP intensity and activity limitations were −1.33 (−2.34; −0.32) and −0.76 (−1.85; 0.34) at short term, −2.22 (−5.34; 0.90) and −1.60 (−3.51; 0.32) at intermediate term and −1.11 (−2.91; 0.70) and −0.63 (−1.68; 0.42) at long term, respectively. Odds ratios (95% CI) for serious and minor adverse events with GC IDTs were 1.09 (0.25; 4.65) and 0.97 (0.49; 1.91). Conclusion: GC IDTs are associated with a reduction in LBP intensity at short term in people with NScLBP. Positive effects are not sustained. IDTs have no effect on activity limitations. Our conclusions are limited by high heterogeneity and a limited methodological quality across studies. Registration PROSPERO: CRD42019106336.

scholarly journals Can patient-reported profiles avoid unnecessary referral to a spine surgeon? An observational study to further develop the Nijmegen Decision Tool for Chronic Low Back Pain

PLoS ONE ◽  
2018 ◽  
Vol 13 (9) ◽  
pp. e0203518 ◽  
Author(s):  
Miranda L. van Hooff ◽  
Johanna M. van Dongen ◽  
Veerle M. Coupé ◽  
Maarten Spruit ◽  
Raymond W. J. G. Ostelo ◽  
...  
Keyword(s):  
Low Back Pain ◽  
Back Pain ◽  
Observational Study ◽  
Chronic Low Back Pain ◽  
Low Back ◽  
Decision Tool ◽  
Patient Reported ◽  
Spine Surgeon

scholarly journals An Observational Study Comparing Fibromyalgia and Chronic Low Back Pain in Somatosensory Sensitivity, Motor Function and Balance

Healthcare ◽  
2021 ◽  
Vol 9 (11) ◽  
pp. 1533
Author(s):  
José Antonio Mingorance ◽  
Pedro Montoya ◽  
José García Vivas Miranda ◽  
Inmaculada Riquelme
Keyword(s):  
Chronic Pain ◽  
Low Back Pain ◽  
Back Pain ◽  
Observational Study ◽  
Motor Function ◽  
Chronic Low Back Pain ◽  
Functional Performance ◽  
Low Back ◽  
Somatosensory Sensitivity ◽  
Chronic Pain Conditions

Fibromyalgia (FM) and chronic low back pain (CLBP) have shared pathophysiology and have a considerable impact on patients’ daily activities and quality of life. The main objective of this study was to compare pain impact, somatosensory sensitivity, motor functionality, and balance among 60 patients with FM, 60 patients with CLBP, and 60 pain-free controls aged between 30 and 65 years. It is essential to know the possible differences existing in symptomatology of two of the major chronic pain processes that most affect the population, such as FM and CLBP. The fact of establishing possible differences in sensory thresholds, motor function, and proprioceptive measures among patients with FM and CLBP could bring us closer to a greater knowledge of the chronic pain process. Through an observational study, a comparison was made between the three groups (FM, CLBP, and pain-free controls) evaluating functional performance, postural balance, kinematic gait parameters, strength, depression, fatigue, and sensitivity to pain and vibration. Patients with chronic pain showed worse somatosensory sensitivity (p < 0.001) and motor function (p < 0.001) than pain-free controls. Moreover, patients with FM showed greater pain impact (p < 0.001) and bigger somatosensory (p < 0.001) and motor deficiencies (p < 0.001) than patients with CLBP. Further research should explore the possible reasons for the greater deterioration in patients with FM in comparison with other chronic pain conditions. Our results, showing the multiple areas susceptible of deterioration, make it necessary to adopt interdisciplinary interventions focused both on physical and emotional dysfunction.

scholarly journals Differences in dynamic and postural stability based on degree of disability in patients with nonspecific chronic lower back pain: an observational study

2021 ◽  
Vol 3 (1) ◽  
Author(s):  
Mónica Grande-Alonso ◽  
Raquel Pérez-Muñoz ◽  
José María Aceña-García ◽  
Francisco Fernando Recio-Mateo ◽  
Diego Pro-Marín ◽  
...  
Keyword(s):  
Low Back Pain ◽  
Back Pain ◽  
Observational Study ◽  
Chronic Low Back Pain ◽  
Postural Stability ◽  
Dynamic Balance ◽  
Forward Direction ◽  
Static Stability ◽  
Chronic Lower Back Pain ◽  
Low Back

Objetive: The main objective of this study was to analyze whether there were differences in dynamic balance and postural stability in relation to the level of disability in patients with chronic low back pain. Methodss: This is an observational study in which 60 patients with nonspecific chronic low back pain were included. All patients received a sociodemographic questionnaire, the visual analogue scale (VAS) and a series of self-reported psychological scales. To complete the evaluation, physical tests were performed in which dynamic balance and postural stability were measured. Results: Student’s t-test revealed that there were significant differences between the groups in dynamic balance with the right leg and the left leg. In contrast, there were no significant differences between the groups for the reach functional test in forward direction, left direction and right direction. Conclusion: In conclusion, our study demonstrates that patients with chronic low back pain with high levels of disability present significantly poorer dynamic balance compared with those with low levels of disability. In contrast, no significant differences were found between the groups in terms of static stability.

scholarly journals The effect of pregabalin treatment on balance and gait in patients with chronic low back pain: a retrospective observational study

2019 ◽  
Vol 8 (1) ◽  
pp. 32-35
Author(s):  
Sibel Çağlar Okur ◽  
Meltem Vural ◽  
Yasemin Pekin Doğan ◽  
Murat Mert ◽  
Nil Sayıner Çağlar
Keyword(s):  
Low Back Pain ◽  
Back Pain ◽  
Observational Study ◽  
Chronic Low Back Pain ◽  
Retrospective Observational Study ◽  
Low Back

scholarly journals Effect of Nonspecific Chronic Low Back Pain on Walking Economy: An Observational Study

2015 ◽  
Vol 48 (3) ◽  
pp. 218-226 ◽  
Author(s):  
Alberito Rodrigo Carvalho ◽  
Welds Rodrigo Ribeiro Bertor ◽  
Ronaldo Valdir Briani ◽  
Gabriela Matté Zanini ◽  
Lígia Inez Silva ◽  
...  
Keyword(s):  
Low Back Pain ◽  
Back Pain ◽  
Observational Study ◽  
Chronic Low Back Pain ◽  
Low Back ◽  
Walking Economy

scholarly journals The costs and consequences of acupuncture for chronic low back pain in Korean patients: an observational study

2015 ◽  
Vol 4 (1) ◽  
pp. 103
Author(s):  
Song-Yi Kim ◽  
Hyejung Lee ◽  
Hyangsook Lee ◽  
Ji-Yeun Park ◽  
Sang Kyun Park ◽  
...  
Keyword(s):  
Low Back Pain ◽  
Back Pain ◽  
Observational Study ◽  
Chronic Low Back Pain ◽  
Low Back ◽  
Korean Patients

scholarly journals Buprenorphine Transdermal System for Opioid Therapy in Patients with Chronic Low Back Pain

2010 ◽  
Vol 15 (3) ◽  
pp. 169-178 ◽  
Author(s):  
Allan Gordon ◽  
Saifudin Rashiq ◽  
Dwight E Moulin ◽  
Alexander J Clark ◽  
André D Beaulieu ◽  
...  
Keyword(s):  
Low Back Pain ◽  
Back Pain ◽  
Visual Analogue Scale ◽  
Chronic Low Back Pain ◽  
Analogue Scale ◽  
Opioid Therapy ◽  
Ordinal Scale ◽  
Low Back ◽  
Rescue Analgesia ◽  
Pain Disability

OBJECTIVE: The present randomized, double-blinded, crossover study compared the efficacy and safety of a seven-day buprenorphine transdermal system (BTDS) and placebo in patients with low back pain of moderate or greater severity for at least six weeks.METHODS: Prestudy analgesics were discontinued the evening before random assignment to 5 μg/h BTDS or placebo, with acetaminophen 300 mg/codeine 30 mg, one to two tablets every 4 h to 6 h as needed, for rescue analgesia. The dose was titrated to effect weekly, if tolerated, to 10 μg/h and 20 μg/h BTDS. Each treatment phase was four weeks.RESULTS: Fifty-three patients (28 men, 25 women, mean [± SD] age 54.5±12.7 years) were evaluable for efficacy (completed two weeks or more in each phase). Baseline pain was 62.1±15.5 mm (100 mm visual analogue scale) and 2.5±0.6 (five-point ordinal scale). BTDS resulted in lower mean daily pain scores than in the placebo group (37.6±20.7 mm versus 43.6±21.2 mm on a visual analogue scale, P=0.0487; and 1.7±0.6 versus 2.0±0.7 on the ordinal scale, P=0.0358). Most patients titrated to the highest dose of BTDS (59% 20 μg/h, 31% 10 μg/h and 10% 5 μg/h). There were improvements from baseline in pain and disability (Pain Disability Index), Pain and Sleep (visual analogue scale), Quebec Back Pain Disability Scale and Short-Form 36 Health Survey scores for both BTDS and placebo groups, without significant differences between treatments. While there were more opioid-related side effects with BTDS treatment than with placebo, there were no serious adverse events. A total of 82% of patients chose to continue BTDS in a long-term open-label evaluation, in whom improvements in pain intensity, functionality and quality of life were sustained for up to six months without analgesic tolerance.CONCLUSION: BTDS (5 μg/h to 20 μg/h) represents a new treatment option for initial opioid therapy in patients with chronic low back pain.

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