A novel HPLC–MS/MS method for the simultaneous determination of astemizole and its major metabolite in dog or monkey plasma and application to pharmacokinetics

Journal of Pharmaceutical and Biomedical Analysis ◽

10.1016/j.jpba.2015.04.036 ◽

2015 ◽

Vol 114 ◽

pp. 121-126 ◽

Author(s):

Hyun-moon Back ◽

Jong-Hwa Lee ◽

Jung-woo Chae ◽

Byungjeong Song ◽

Joung-Wook Seo ◽

...

Keyword(s):

Simultaneous Determination ◽

Major Metabolite ◽

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Toxicokinetics of diisobutyl phthalate and its major metabolite, monoisobutyl phthalate, in rats: UPLC-ESI-MS/MS method development for the simultaneous determination of diisobutyl phthalate and its major metabolite, monoisobutyl phthalate, in rat plasma, urine, feces, and 11 various tissues collected from a toxicokinetic study

Food and Chemical Toxicology ◽

10.1016/j.fct.2020.111747 ◽

2020 ◽

Vol 145 ◽

pp. 111747

Author(s):

Seung-Hyun Jeong ◽

Ji-Hun Jang ◽

Hea-Young Cho ◽

Yong-Bok Lee

Keyword(s):

Simultaneous Determination ◽

Method Development ◽

Major Metabolite ◽

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Simultaneous Determination of Trimethadione and Its Metabolite, Dimethadione, by Gas—Liquid Chromatography

Clinical Chemistry ◽

10.1093/clinchem/17.7.607 ◽

1971 ◽

Vol 17 (7) ◽

pp. 607-609 ◽

Author(s):

H E Booker ◽

B Darcey

Keyword(s):

Liquid Chromatography ◽

Simultaneous Determination ◽

Major Metabolite ◽

Gas Liquid Chromatography ◽

Single Extraction ◽

Chromatographic Procedure

Abstract A simple gas chromatographic procedure is described for the measurement of trimethadione and its major metabolite, dimethadione, in serum. The method, with which compounds can be determined on a single extraction and injection, is reliable and free from interference caused by other drugs, particularly those that the patient is likely to be taking in combination with trimethadione.

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Sensitive GLC Procedure for Simultaneous Determination of Phenytoin and its Major Metabolite from Plasma Following Single Doses of Phenytoin

Journal of Pharmaceutical Sciences ◽

10.1002/jps.2600650827 ◽

1976 ◽

Vol 65 (8) ◽

pp. 1240-1243 ◽

Author(s):

K.K. Midha ◽

I.J. McGilveray ◽

D.L. Wilson

Keyword(s):

Simultaneous Determination ◽

Major Metabolite

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Simultaneous determination of piroxicam and its major metabolite 5′-hydroxypiroxicam in human plasma by derivative spectrophotometry

The Analyst ◽

10.1039/a802318b ◽

1998 ◽

Vol 123 (8) ◽

pp. 1749-1752 ◽

Author(s):

Vicente Ródenas

Keyword(s):

Simultaneous Determination ◽

Human Plasma ◽

Major Metabolite ◽

Derivative Spectrophotometry

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Simultaneous determination of triazolo-benzophenone [2′,5-dichloro-2-(3-glycylaminomethyl-5-methyl-4H-1,2,4-triazol-4-yl)-benzophenone] and its major blood metabolite, triazolam, in monkey plasma by electron-capture gas—liquid chromatography

Journal of Chromatography B Biomedical Sciences and Applications ◽

10.1016/s0378-4347(00)84278-4 ◽

1982 ◽

Vol 229 (2) ◽

pp. 355-363 ◽

Author(s):

Masaharu Konishi ◽

Yoshio Mori ◽

Kentaro Hirai

Keyword(s):

Liquid Chromatography ◽

Simultaneous Determination ◽

Electron Capture ◽

Gas Liquid Chromatography ◽

Blood Metabolite ◽

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A rapid and selective LC method for simultaneous determination of cyclosporin a and its major metabolite (AM1) in human serum at room temperature

Talanta ◽

10.1016/s0039-9140(03)00014-6 ◽

2003 ◽

Vol 59 (6) ◽

pp. 1089-1094 ◽

Author(s):

N Golabi

Keyword(s):

Cyclosporin A ◽

Human Serum ◽

Simultaneous Determination ◽

Room Temperature ◽

Major Metabolite

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Simultaneous Determination of CGS 10787B and Its Major Metabolite (CGS 12094) in Plasma by High Performance Liquid Chromatography

Analytical Letters ◽

10.1080/00032718608080876 ◽

1986 ◽

Vol 19 (21-22) ◽

pp. 2183-2196

Author(s):

Richard C. Luders ◽

Linda A. Brunner ◽

Lisa B. Giedraitis

Keyword(s):

High Performance Liquid Chromatography ◽

Liquid Chromatography ◽

Simultaneous Determination ◽

High Performance ◽

Major Metabolite

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Validation and application of an LC–ESI-MS method for simultaneous determination of astilbin and its major metabolite 3′-O-methylastilbin in rat plasma

Journal of Chromatography B ◽

10.1016/j.jchromb.2009.04.040 ◽

2009 ◽

Vol 877 (18-19) ◽

pp. 1765-1770 ◽

Author(s):

Yan Liang ◽

Qiang Xu ◽

An Kang ◽

Yuan Xie ◽

Tong Xie ◽

...

Keyword(s):

Simultaneous Determination ◽

Major Metabolite ◽

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A Rapid HPLC Method for the Simultaneous Determination of Amiodarone and its Major Metabolite in Rat Plasma and Tissues: A Useful Tool for Pharmacokinetic Studies

Journal of Chromatographic Science ◽

10.1093/chromsci/bms149 ◽

2012 ◽

Vol 51 (4) ◽

pp. 361-370 ◽

Author(s):

M. Rodrigues ◽

G. Alves ◽

A. Ferreira ◽

J. Queiroz ◽

A. Falcao

Keyword(s):

Simultaneous Determination ◽

Hplc Method ◽

Major Metabolite ◽

Pharmacokinetic Studies

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Identification of a major metabolite of danshensu in rat urine and simultaneous determination of danshensu and its metabolite in plasma: application to a pharmacokinetic study in rats

Drug Testing and Analysis ◽

10.1002/dta.1750 ◽

2014 ◽

Vol 7 (8) ◽

pp. 727-736 ◽

Author(s):

Xiangyang Wang ◽

Wei Li ◽

Xiaohui Ma ◽

Kaijing Yan ◽

Yang Chu ◽

...

Keyword(s):

Simultaneous Determination ◽

Pharmacokinetic Study ◽

Major Metabolite ◽

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