scholarly journals Simultaneous determination of domperidone and Itopride in pharmaceuticals and human plasma using RP-HPLC/UV detection: Method development, validation and application of the method in in-vivo evaluation of fast dispersible tablets

2016 ◽  
Vol 121 ◽  
pp. 6-12 ◽  
Author(s):  
Amjad Khan ◽  
Zafar Iqbal ◽  
Ibrahim Khadra ◽  
Lateef Ahmad ◽  
Abad Khan ◽  
...  
Keyword(s):  
Simultaneous Determination ◽  
Human Plasma ◽  
Method Development ◽  
Detection Method ◽  
Uv Detection ◽  
In Vivo Evaluation ◽  
Rp Hplc ◽  
Dispersible Tablets

Validated HPLC-UV detection method for the simultaneous determination of ceftolozane and tazobactam in human plasma

Bioanalysis ◽  
2018 ◽  
Vol 10 (7) ◽  
pp. 461-473 ◽  
Author(s):  
Carlos Ezquer-Garin ◽  
Rafael Ferriols-Lisart ◽  
Manuel Alós-Almiñana ◽  
Gerardo Aguilar-Aguilar ◽  
Javier F Belda-Nacher ◽  
...  
Keyword(s):  
Simultaneous Determination ◽  
Human Plasma ◽  
Detection Method ◽  
Uv Detection

scholarly journals Liquid Chromatographic Method for the Simultaneous Determination of Eprosartan and Hydrochlorothiazide in Tablets and Human Plasma

2011 ◽  
Vol 94 (3) ◽  
pp. 823-832 ◽  
Author(s):  
Fathalla Belal ◽  
Amina M El-Brashy ◽  
Nahed El-Enany ◽  
Manar M Tolba
Keyword(s):  
Simultaneous Determination ◽  
Human Plasma ◽  
Mobile Phase ◽  
Hplc Method ◽  
Rp Hplc ◽  
Liquid Chromatographic Method ◽  
Liquid Chromatographic

Abstract A new, specific, and sensitive RP-HPLC method was developed for the simultaneous determination of eprosartan (EPR) and hydrochlorothiazide (HCT). Good chromatographic separation was achieved using a 250 × 4.6 mm id, 5 μm particle size Symmetry® C18 column. The mobile phase acetonitrile–0.1 M phosphate buffer (35 + 65, v/v), pH 4.5, was pumped at a flow rate of 1 mL/min, with UV detection at 275 nm. The method showed good linearity in the ranges of 0.5–50 and 0.1–10 μg/mL, with LOD of 0.06 and 0.02 μg/mL and LOQ of 0.20 and 0.08 μg/mL for EPR and HCT, respectively. The proposed method was successfully applied for the analysis of the studied drugs in their synthetic mixture and co-formulated tablets. The method was further extended to the in vitro and in vivo determination of the two drugs in spiked and real human plasma. Interference likely to be encountered from the co-administered drugs was studied.

RP-HPLC method development for simultaneous determination of the drugs Ramipril and Amlodipine

2012 ◽  
Vol 2 (2) ◽  
pp. 364-367 ◽  
Author(s):  
Saida Naik Dheeravath ◽  
◽  
Kasani Ramadevi ◽  
Zilla Saraswathi ◽  
Dheeravath Maniklal ◽  
...  
Keyword(s):  
Simultaneous Determination ◽  
Method Development ◽  
Hplc Method ◽  
Rp Hplc ◽  
Hplc Method Development
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