Stability behaviour of antiretroviral drugs and their combinations. 2: Characterization of interaction products of lamivudine and tenofovir disoproxil fumarate by mass and NMR spectrometry

2016 ◽  
Vol 125 ◽  
pp. 245-259 ◽  
Author(s):  
Moolchand Kurmi ◽  
Bhoopendra Singh Kushwah ◽  
Archana Sahu ◽  
Mallikarjun Narayanam ◽  
Saranjit Singh
Keyword(s):  
Tenofovir Disoproxil Fumarate ◽  
Antiretroviral Drugs ◽  
Stability Behaviour ◽  
Nmr Spectrometry

Stability behaviour of antiretroviral drugs and their combinations. 1: characterization of tenofovir disoproxil fumarate degradation products by mass spectrometry

RSC Advances ◽  
2015 ◽  
Vol 5 (116) ◽  
pp. 96117-96129 ◽  
Author(s):  
Moolchand Kurmi ◽  
Vijaya Madhyanapu Golla ◽  
Sanjay Kumar ◽  
Archana Sahu ◽  
Saranjit Singh
Keyword(s):  
Mass Spectrometry ◽  
Tenofovir Disoproxil Fumarate ◽  
Degradation Products ◽  
Antiretroviral Drugs ◽  
Degradation Behaviour ◽  
Stability Behaviour ◽  
Intrinsic Degradation

The investigation established the intrinsic degradation behaviour of tenofovir disoproxil fumarate in solid and solution states.

Structural Characterization of VGOs from Western Region Crudes by NMR Spectrometry

2003 ◽  
Vol 21 (1-2) ◽  
pp. 125-132 ◽  
Author(s):  
B. M. L. Bhatia ◽  
B. S. Goyal ◽  
D. S. Aswal ◽  
M. K. S. Aloopwan ◽  
G. C. Kothari
Keyword(s):  
Structural Characterization ◽  
Western Region ◽  
Nmr Spectrometry

scholarly journals Determination of Site-Specific (Deuterium/Hydrogen) Ratios in Vanillin by 2H-NuclearMagnetic Resonance Spectrometry: Collaborative Study

2007 ◽  
Vol 90 (1) ◽  
pp. 187-195 ◽  
Author(s):  
Eric Jamin ◽  
Frédérique Martin ◽  
Gilles G Martin ◽  
I Billault ◽  
A -I Blanch-Cortès ◽  
...  
Keyword(s):  
Standard Deviation ◽  
Collaborative Study ◽  
Official Method ◽  
Site Specific ◽  
Hydrogen Position ◽  
Nmr Spectrometry ◽  
Measuring Site ◽  
Commercial Sources

Abstract The results of collaborative study are reported for a method that determines the site-specific isotope ratios of deuterium/hydrogen (D/H)i in vanillin by deuterium-nuclear magnetic resonance (2H-NMR) spectrometry. This method allows characterization of all the main commercial sources of commercial vanillin and detection of undeclared mixtures. It is based on the fact that the amounts of deuterium at various positions in the vanillin molecule are significantly different from one source to another. Vanillin is dissolved in acetonitrile and analyzed with a high-field NMR spectrometer fitted with a deuterium probe and a fluorine lock. The proportions of isotopomers monodeuterated at each hydrogen position of the molecule are recorded, and the corresponding (D/H) ratios are determined by using a calibrated reference. Nine laboratories analyzed 5 materials supplied as blind duplicates (1 natural vanillin from vanilla beans, 2 synthetic vanillins from guaiacol, 1 semisynthetic vanillin from lignin, and a mixture of natural and synthetic vanillins). The precision of the method for measuring site-specific ratios was as follows: for (D/H)1 the within-laboratory standard deviation (sr) values ranged from 2.2 to 5.8 ppm, and the among-laboratories standard deviation (sR) values ranged from 3.6 to 5.1 ppm; for (D/H)3 the sr values ranged from 1.7 to 3.2 ppm, and the sR values ranged from 2.4 to 3.7 ppm; for (D/H)4 the sr values ranged from 2.3 to 6.2 ppm, and the sR values ranged from 2.4 to 6.4 ppm; for (D/H)5 the sr values ranged from 0.8 to 2.7 ppm, and the sR values ranged from 0.9 to 2.3 ppm. It was shown that these values allow a satisfactory discrimination between vanillin sources. Therefore, the Study Director recommends the method for adoption as a First Action Official Method by AOAC INTERNATIONAL.

Characterization of Mutations in HIV Type 1 Isolates from 144 Cambodian Recently Infected Patients and Pregnant Women Naive to Antiretroviral Drugs

2005 ◽  
Vol 21 (11) ◽  
pp. 971-976 ◽  
Author(s):  
Nary Ly ◽  
Patricia Recordon-Pinson ◽  
Viseth Phoung ◽  
Chanthan Srey ◽  
Leang Sim Kruy ◽  
...  
Keyword(s):  
Pregnant Women ◽  
Antiretroviral Drugs ◽  
Hiv Type 1
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