Heparin-binding epidermal growth factor–like growth factor reduces intestinal apoptosis in neonatal rats with necrotizing enterocolitis

2006 ◽  
Vol 41 (4) ◽  
pp. 742-747 ◽  
Author(s):  
Jiexiong Feng ◽  
Osama N. El-Assal ◽  
Gail E. Besner
Keyword(s):  
Growth Factor ◽  
Epidermal Growth Factor ◽  
Necrotizing Enterocolitis ◽  
Heparin Binding ◽  
Neonatal Rats ◽  
Epidermal Growth

scholarly journals Heparin-binding epidermal growth factor–like growth factor overexpression in transgenic mice increases resistance to necrotizing enterocolitis

2010 ◽  
Vol 45 (10) ◽  
pp. 1933-1939 ◽  
Author(s):  
Andrei Radulescu ◽  
Hong-Yi Zhang ◽  
Xiaoyi Yu ◽  
Jacob K. Olson ◽  
Amanda K. Darbyshire ◽  
...  
Keyword(s):  
Growth Factor ◽  
Epidermal Growth Factor ◽  
Transgenic Mice ◽  
Necrotizing Enterocolitis ◽  
Heparin Binding ◽  
Epidermal Growth

scholarly journals Prenatal administration of heparin-binding epidermal growth factor-like growth factor in an experimental model of necrotizing enterocolitis decreased both incidence and severity of the disease

2022 ◽  
Vol 5 (1) ◽  
pp. e000345
Author(s):  
Marla Ashley Sacks ◽  
Yomara Stephanie Mendez ◽  
Faraz A Khan ◽  
Robert Propst ◽  
Craig W Zuppan ◽  
...  
Keyword(s):  
Growth Factor ◽  
Epidermal Growth Factor ◽  
Necrotizing Enterocolitis ◽  
Heparin Binding ◽  
Pregnant Rats ◽  
Intraperitoneal Route ◽  
Rat Pups ◽  
Gut Barrier Function ◽  
Epidermal Growth ◽  
Severity Of The Disease

BackgroundNecrotizing enterocolitis (NEC) is the leading gastrointestinal cause of death in premature infants and causes long-term disabilities. Previously, enteral heparin-binding epidermal growth factor-like growth factor (HB-EGF) administered after birth demonstrated decreased incidence and severity of NEC in a neonatal animal model of NEC. We investigated the potential prophylactic strategy of preventing NEC using prenatally administered HB-EGF.MethodsAn HB-EGF (800 µg/kg/dose) dose was injected into pregnant rats via tail vein or intraperitoneal route 2 hours prior to delivery. After cesarean section (C-section) at 21 days’ gestation, the rat pups were subjected to the NEC protocol by inducing stressors: hypoxia, hypothermia, hypertonic feeds, and orogastric gavage of lipopolysaccharide (2 mg/kg). Postnatally, pups were monitored for 96 hours and assessed for the development of clinical and postmortem histological NEC.ResultsThe experimental NEC incidence in untreated, stressed rat pups was 66%. Compared with untreated pups, the maternal administration of HB-EGF correlated with a significant NEC incidence and severity decrease in rat pups. The strongest decrease was seen when HB-EGF was administered via the intraperitoneal route 2 hours prior to C-section (66% vs 31%, *p<0.05). Prenatal HB-EGF administration significantly increased pups’ survival after NEC protocol exposure, with the greatest benefit observed in the group that received HB-EGF intraperitoneally 2 hours before delivery.ConclusionsPrenatal administration of HB-EGF decreases the incidence and severity of NEC, preserves gut barrier function and increases survival. This may represent a novel prophylactic clinical strategy for NEC offered to mothers at risk of delivering a premature infant.

scholarly journals Heparin-binding epidermal growth factor-like growth factor is an autocrine growth factor for human keratinocytes.

1994 ◽  
Vol 269 (31) ◽  
pp. 20060-20066 ◽  
Author(s):  
K. Hashimoto ◽  
S. Higashiyama ◽  
H. Asada ◽  
E. Hashimura ◽  
T. Kobayashi ◽  
...  
Keyword(s):  
Growth Factor ◽  
Epidermal Growth Factor ◽  
Human Keratinocytes ◽  
Heparin Binding ◽  
Autocrine Growth ◽  
Autocrine Growth Factor ◽  
Epidermal Growth

scholarly journals Differential Pathways of Angiotensin II-Induced Extracellularly Regulated Kinase 1/2 Phosphorylation in Specific Cell Types: Role of Heparin-Binding Epidermal Growth Factor

2004 ◽  
Vol 18 (8) ◽  
pp. 2035-2048 ◽  
Author(s):  
Bukhtiar H. Shah ◽  
Akin Yesilkaya ◽  
J. Alberto Olivares-Reyes ◽  
Hung-Dar Chen ◽  
László Hunyady ◽  
...  
Keyword(s):  
Angiotensin Ii ◽  
Growth Factor ◽  
Epidermal Growth Factor ◽  
Cell Types ◽  
Specific Cell ◽  
Heparin Binding ◽  
Epidermal Growth
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