scholarly journals Optimization and validation of a fast RP–HPLC method for the determination of dobutamine in rat plasma: Pharmacokinetic studies in healthy rat subjects

2013 ◽  
Vol 3 (6) ◽  
pp. 434-439 ◽  
Author(s):  
Ramesh Thippani ◽  
Nageswara Rao Pothuraju ◽  
Nageswara Rao Ramisetti ◽  
Saida Shaik
Keyword(s):  
Rat Plasma ◽  
Hplc Method ◽  
Pharmacokinetic Studies ◽  
Rp Hplc ◽  
Plasma Pharmacokinetic

Ecofriendly chromatographic methods for determination of co-prescribed drugs, olanzapine and metformin, in rat plasma

Bioanalysis ◽  
2020 ◽  
Vol 12 (9) ◽  
pp. 597-613
Author(s):  
Aml A Emam ◽  
Neven M Habib ◽  
Hamada M Mahmoud ◽  
Nada S Abdelwhab ◽  
Maha M Abdelrahman
Keyword(s):  
Pharmaceutical Preparation ◽  
Rat Plasma ◽  
Reversed Phase ◽  
Hplc Method ◽  
Hypoglycemic Agent ◽  
Chromatographic Methods ◽  
Rp Hplc ◽  
Development And Validation ◽  
Developing System

Background: Olanzapine (OLZ) is one of most recommended drugs for the treatment of schizophrenia while metformin (MET) is the most commonly used hypoglycemic agent. Aim: Development and validation of two green, sensitive and accurate chromatographic methods for the simultaneous determination of OLZ along with the co-prescribed, MET. Materials & methods: TLC-densitometric method with a developing system consisting of methylene chloride:methanol:ethyl acetate:triethylamine (4:4:5:0.1, by volume) and a reversed-phase (RP)-HPLC method where the chromatographic separation was performed using ethanol:water mixture (50: 50, v/v) as a mobile phase. Results: TLC-densitometric method had linearity over concentration ranges of 160–4000 ng/band for OLZ and 150–4500 ng/band for MET, while RP-HPLC method was linear and validated over concentration range of 300–20000 ng/ml for OLZ and MET. Conclusion: Pharmacokinetic study was successfully performed and suggested the possibility of co-administration of MET with OLZ and their further formulation in one pharmaceutical preparation to enhance patient’s compliance.

A simplified and sensitive validated RP-HPLC method for determination of temozolomide in rat plasma and its application to a pharmacokinetic study

2018 ◽  
Vol 41 (10) ◽  
pp. 692-697 ◽  
Author(s):  
Archana Khosa ◽  
Kowthavarapu V. Krishna ◽  
Ranendra N. Saha ◽  
Sunil K. Dubey ◽  
Satish Reddi
Keyword(s):  
Pharmacokinetic Study ◽  
Rat Plasma ◽  
Hplc Method ◽  
Rp Hplc

scholarly journals Development and validation of RP-HPLC method for sildenafil citrate in rat plasma-application to pharmacokinetic studies

2013 ◽  
Vol 21 (3) ◽  
pp. 317-321 ◽  
Author(s):  
A.S. Tripathi ◽  
I. Sheikh ◽  
A.P. Dewani ◽  
P.G. Shelke ◽  
R.L. Bakal ◽  
...  
Keyword(s):  
Rat Plasma ◽  
Hplc Method ◽  
Sildenafil Citrate ◽  
Pharmacokinetic Studies ◽  
Rp Hplc ◽  
Development And Validation

An HPLC Method for Determination of a New Diorganotin(IV)Benzohydroxamate in Rat Plasma and Its Application to Pharmacokinetic Studies

2008 ◽  
Vol 26 (9) ◽  
pp. 1630-1634 ◽  
Author(s):  
Yun-Lan LI ◽  
Yong LI ◽  
Jin-Jie LIU ◽  
Li YANG ◽  
Xiao-Qiang NIU ◽  
...  
Keyword(s):  
Rat Plasma ◽  
Hplc Method ◽  
Pharmacokinetic Studies
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