AbstractAdrenal venous sampling is the standard of care for identifying patients with
unilateral primary aldosteronism, which is often caused by an aldosterone
producing adenoma and can be cured with surgery. The numerous limitations of
adrenal venous sampling, including its high cost, scarce availability, technical
challenges, and lack of standardized protocols, have driven efforts to develop
alternative, non-invasive tools for the diagnosis of aldosterone producing
adenomas. Seminal discoveries regarding the pathogenesis of aldosterone
producing adenomas made over the past decade have leveraged hypotheses-driven
research of steroid phenotypes characteristic of various aldosterone producing
adenomas. In parallel, the expanding availability of mass spectrometry has
enabled the simultaneous quantitation of many steroids in single assays from
small volume biosamples. Steroid profiling has contributed to our evolving
understanding about the pathophysiology of primary aldosteronism and its
subtypes. Herein, we review the current state of knowledge regarding the
application of multi-steroid panels in assisting with primary aldosteronism
subtyping.
Developments in Primary Aldosteronism Subtyping Using Steroid
Profiling
