Balloon Kyphoplasty for Refractory Vertebral Compression Fractures in a Growing Child With Duchenne Muscular Dystrophy With Five-Year Follow-Up: Case Report and Review of Literature

2014 ◽  
Vol 2 (2) ◽  
pp. 152-157
Author(s):  
Jan William Duncan ◽  
Richard Anthony Bailey
Keyword(s):  
Case Report ◽  
Duchenne Muscular Dystrophy ◽  
Muscular Dystrophy ◽  
Balloon Kyphoplasty ◽  
Vertebral Compression Fractures ◽  
Review Of Literature ◽  
Compression Fractures

scholarly journals Kyphoplasty for the Treatment of Vertebral Compression Fractures in a Cancer Patient with Neurological Deficits and Anterior Vertebral Wall Destruction

2011 ◽  
Vol 6;14 (6;12) ◽  
pp. 539-544
Author(s):  
Sang Sik Choi
Keyword(s):  
Case Report ◽  
Bone Cement ◽  
Tumor Metastasis ◽  
Balloon Kyphoplasty ◽  
Neurological Deficits ◽  
Vertebral Compression Fractures ◽  
Injection Technique ◽  
Lower Extremity Weakness ◽  
Compression Fractures ◽  
Cement Injection

Background: Percutaneous balloon kyphoplasty is an effective, minimally invasive procedure that is used to relieve pain and stabilize spine fractures caused by severe osteoporosis or osteolysis due to tumor metastasis. However, there remains a risk of bone cement leakage during and after kyphoplasty, especially in cases with severe vertebral wall destruction or neurological deficits. Objective: This article presents a case in which kyphoplasty was used to manage these complications in a woman with vertebral compression fractures caused by tumor metastasis. Design: Case report. Setting: Pain management clinic. Methods: The patient was a 76-year-old woman who had severe low back pain, lower extremity weakness, and cauda equina syndrome because of vertebral compression fracture and spinal metastasis with epidural involvement. The patient had a large bony defect in the vertebra that the bone filler device could pass freely through the anterior body wall. Nevertheless, kyphoplasty was successfully performed by using our new cement injection technique, which is a slow injection of the highly viscous bone cement, followed by a second injection 10 minutes later to allow the previously injected cement to harden. Results: The procedure significantly alleviated all symptoms. The day after the procedure, in the absence of additional pain medication, the pain had dropped dramatically to a numerical rating scale 3-4, and there was an improvement in motor function that allowed the patient to sit and go to the bathroom by herself. In addition, the voiding sensation had returned, which allowed the patient to defecate and urinate normally. Limitations: This report describes a single case report. Conclusion: Our new cement injection technique may allow balloon kyphoplasty to be safely and effectively performed in cancer patients with pathological vertebral compression fractures, even if there are large defects in the anterior vertebral wall and neurological deficits. Key words: Compression fractures, kyphoplasty, metastasis, neurological deficits, osteolysis, polymethylmethacrylate.

New phenotype caused by POMGNT2 mutations

2021 ◽  
Vol 14 (7) ◽  
pp. e242358
Author(s):  
Marco Cassone ◽  
Chiara Fiorillo ◽  
Federico Zara ◽  
Carlo Vitali
Keyword(s):  
Case Report ◽  
Muscular Dystrophy ◽  
Missense Mutation ◽  
Genetic Screening ◽  
Gene Mutations ◽  
Intermediate Phenotype ◽  
Review Of Literature ◽  
Mild Form ◽  
Phenotype Correlation

We present a case report about a Moroccan 3-year-old girl, with an intermediate phenotype of muscular dystrophy-dystroglycanopathy (congenital with brain and eye anomalies), type A, 8 form. We performed clinical and instrumental evaluation, muscle biopsy, genetic screening of 59 genes for different cerebral malformations, follow-up and review of literature. After investigations, we identified an intermediate new phenotype between the severe and mild form, characterised by significant malformations of the cortex with myopatic symptoms, this increases the genotype–phenotype correlation knowledge about POMGNT2 gene mutations. New homozygous missense mutation on POMGNT2 (c.511 G>A, p.Asp171Asn, rs768063378) was detected.

Preliminary results of balloon kyphoplasty for vertebral compression fractures in organ transplant recipients

2005 ◽  
Vol 18 (3) ◽  
pp. 1-4 ◽  
Author(s):  
H. Gordon Deen ◽  
Jaime Aranda-Michel ◽  
Ronald Reimer ◽  
John D. Putzke
Keyword(s):  
Organ Transplant ◽  
Balloon Kyphoplasty ◽  
Vertebral Compression Fractures ◽  
Transplant Recipients ◽  
Organ Transplant Recipients ◽  
Compression Fractures ◽  
History Of ◽  
The Mean ◽  
Cement Extravasation

Object Organ transplant recipients are at risk for vertebral compression fractures (VCFs). The goal of this study was to determine whether kyphoplasty is an effective treatment for VCFs that develop in this patient population. Methods Six consecutive patients who had undergone an organ transplant (five liver and one kidney transplant) had a total of 13 symptomatic VCFs that were treated with balloon kyphoplasty. Postprocedure follow-up duration ranged from 6 to 12 months. The mean visual analog scale pain score was 9.3 before treatment and declined to 1.8 after treatment. This improvement was highly significant (p < 0.001). Intake of narcotic drugs decreased or was eliminated in all patients, and there were no complications related to the procedure. There was one instance of clinically insignificant extraosseous cement extravasation. Sagittal alignment was improved by 5° in one patient and was unchanged in the remaining five. During the follow-up period, a new fracture developed adjacent to a treated level in one patient. This was successfully treated with an additional kyphoplasty procedure. Conclusions Kyphoplasty can be performed safely in organ transplant recipients with VCF, in whom results are just as favorable as those seen in patients with no history of organ transplantation.

scholarly journals Balloon Kyphoplasty for Acute Osteoporotic Compression Fractures

2010 ◽  
Vol 16 (1) ◽  
pp. 65-70 ◽  
Author(s):  
T. Yang ◽  
S. Liu ◽  
X. Lv ◽  
Z. Wu
Keyword(s):  
Invasive Procedure ◽  
Balloon Kyphoplasty ◽  
Cement Leakage ◽  
Vertebral Compression Fractures ◽  
Minimally Invasive Procedure ◽  
Compression Fractures ◽  
Low Incidence ◽  
Initial Score ◽  
Cement Extravasation

We reviewed the effectiveness of balloon kyphoplasty in the treatment of acute symptomatic vertebral compression fractures. We assessed radiographic and functional outcome in 11 patients with a 24.3 month follow-up from a retrospectively monitored series of 11 patients who underwent balloon kyphoplasty (BKP). A visual analogue scale (VAS) and the short McGill questionnaire (MPQ) were used to assess average symptoms. Eleven patients with 19 treated vertebrae completed the study. The VAS showed significant improvement after treatment: the initial score was 9.1 ± 0.6 (mean ± SD), falling to 2.7 ± 1.07 by 24.3 months (P<0.001). The MPQ also showed a significant improvement (P<0.001) at follow-up. A new fracture was seen in one patient affecting two vertebrae adjacent to the treated level. On CT following the procedure, there was cement leakage in the disc in 9% of cases. BKP is a minimally invasive procedure that has been shown to be effective in the treatment of acute symptomatic vertebral compression fractures. It appears that BKP is associated with a low incidence of procedure-related complications and cement extravasation.

scholarly journals Comparison of High-Viscosity Cement Vertebroplasty and Balloon Kyphoplasty for the Treatment of Osteoporotic Vertebral Compression Fractures

2015 ◽  
Vol 2;18 (2;3) ◽  
pp. E187-E194
Author(s):  
Lin Nie
Keyword(s):  
Balloon Kyphoplasty ◽  
Cement Leakage ◽  
High Viscosity ◽  
Leakage Rate ◽  
Vertebral Compression Fractures ◽  
Osteoporotic Vertebral Compression Fractures ◽  
Vertebral Height ◽  
Compression Fractures ◽  
One Year

Background: Percutaneous vertebroplasty is a widely used vertebral augmentation procedure for treating osteoporotic vertebral compression fractures (OVCFs). But high cement leakage rate caused by a low-viscosity cement and high injection pressure has limited its general use. Balloon kyphoplasty (BKP) and high-viscosity cement vertebroplasty (HVCV) are 2 modifications of vertebroplasty designed to decrease cement leakage. Objective: To assess the safety and efficacy of HVCV compared with BKP. Study Design: A prospective cohort study. Setting: Department of Spine Surgery, an affiliated hospital of a medical university. Method: One hundred seven patients suffering from painful OVCFs were randomly assigned into HVCV or BKP groups. Visual Analog Scale (VAS), Oswestry Disability Index (ODI), cement leakage, and vertebral height restoration were evaluated. All occurring complications and injected cement volumes were recorded. The follow-up time was one year. Results: VAS and ODI scores improved in both groups, and did not differ significantly between the 2 groups. More cement was used in the BKP group than in HVCV group (4.22 vs. 3.31 mL, P < 0.0001). The incidence of cement leakage in the HVCV group was lower than that of the BKP group (13.24% vs 30.56%, P < 0.05). No symptomatic cement leakages occurred in the HVCV group. In the BKP group, one patient experienced discogenic back pain related to a disc leak, and another patient had asymptomatic cement emboli in the lung related to venous leakage. The mean compression rate before the procedure was 29.98% in the HVCV group and 28.67% in the BKP group (P = 0.94). The vertebral height was improved significantly and maintained at one-year follow-up in both groups. BKP was more effective in vertebral height restoration than HVCV (44.87% vs. 23.93%, P < 0.0001). There was one case of a new adjacent vertebral fracture in the HVCV group (2%), and 4 cases of new nonadjacent vertebral fractures in the BKP group (7.84%) (P = 0.18). Limitations: A single-center and relatively small-sample size study. Conclusion: HVCV and BKP are safe and effective in improving quality of life and relieving pain. HVCV has a lower cement leakage rate, whereas BKP is more effective in vertebral height restoration. Subsequent fractures are not different between the 2 groups. Key words: Vertebral compression fracture, spine, osteoporosis, cement augmentation, balloon kyphoplasty, vertebroplasty, cement leakage

‘Double trouble': Duchenne muscular dystrophy and osteogenesis imperfecta in one patient - a case report

2015 ◽  
Author(s):  
Milan Bayer ◽  
Renata Taslerova ◽  
Lenka Mrazova ◽  
Lenka Fajkusova ◽  
Hana Oslejskova
Keyword(s):  
Case Report ◽  
Duchenne Muscular Dystrophy ◽  
Muscular Dystrophy ◽  
Osteogenesis Imperfecta
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