scholarly journals Adverse drug reactions in hospitalized pediatric patients of Saudi Arabian University Hospital and impact of pharmacovigilance in reporting ADR

2013 ◽  
Vol 21 (3) ◽  
pp. 261-266 ◽  
Author(s):  
Lateef M. Khan ◽  
Sameer E. Al-Harthi ◽  
Omar I. Saadah
Keyword(s):  
Adverse Drug Reactions ◽  
Pediatric Patients ◽  
Saudi Arabian ◽  
University Hospital ◽  
Drug Reactions

Adverse Drug Reactions to Cephalosporins in Penicillin Allergic Pediatric Patients

2011 ◽  
Vol 127 (2) ◽  
pp. AB192-AB192
Author(s):  
K.A. Ahmed ◽  
S.J. Fox ◽  
M.A. Park
Keyword(s):  
Adverse Drug Reactions ◽  
Pediatric Patients ◽  
Drug Reactions

scholarly journals INTRAVENOUS APPLICATION OF HELIXOR® IN GYNECOLOGICAL ONCOLOGY: IS IT SAFE?

2017 ◽  
Vol 5 (10) ◽  
pp. 307-312
Author(s):  
Yong-Il Ji
Keyword(s):  
Observational Study ◽  
Adverse Drug Reactions ◽  
Gynecological Cancer ◽  
Viscum Album ◽  
University Hospital ◽  
Drug Reactions ◽  
Gynecological Oncology ◽  
Patients With Cancer ◽  
Therapeutic Outcomes ◽  
Efficacy Studies

Background: Traditional mistletoe (Viscum album L.) therapy has been frequently used in patients with cancer in Europe. The different mistletoe formulations available for oncological use are Iscador®, Iscucin®, AbnovaViscum®, and Lektinol®, as well as Helixor®, which may improve therapeutic outcomes following intravenous (i.v.) administration and therefore, is becoming more commonly used. Method: I conducted an observational study in four different University Hospital Centers and the frequency of adverse drug reactions (ADRs) induced by the i.v. infusion of Helixor® was determined. Result: of the 108 patients with gynecological cancer who received i.v. infusions of Helixor®, 10 (9.3%) reported mild ADRs, and no serious ADRs were reported. Conclusion: Therefore, i.v. infusion of Helixor® was determined to be safe, and prospective efficacy studies are recommended.

Diuretic Drug Utilization Study

1996 ◽  
Vol 12 (4) ◽  
pp. 169-176
Author(s):  
Jaime Torelló ◽  
José A Durán ◽  
María I Serrano
Keyword(s):  
Adverse Drug Reactions ◽  
Diuretic Therapy ◽  
University Hospital ◽  
World Health ◽  
Drug Reactions ◽  
Cardiac Symptoms ◽  
Medicine Service ◽  
Combined Use ◽  
Health Organization ◽  
The University

Objective: To evaluate the present use of diuretics in our institution, and determine the appropriateness of that use and the incidence of adverse reactions and interactions. Design: This retrospective study describes the indications for use of an identified drug or combination of drugs. By the time the data were collected, some patients had been discharged or had died. Setting: The study was carried out in a referral center, the University Hospital “Virgen Macarena,” Seville, Spain. Patients: All patients receiving diuretic therapy. Those undergoing hemodialysis or receiving home care were excluded from the study. Intervention: A therapeutic audit was performed using specific standards of reference. Two models were used — one for each of the most frequent indications, ascites and congestive heart failure (CHF). Main Outcome Measures: A structured protocol gathered data on (1) demographic characteristics, (2) causes of admission and pathologic antecedents, (3) diuretic treatment, (4) basic controls (24-h diuresis and daily basal weight), (5) clinical evolution, and (6) concurrent complementary studies. The protocol included a checklist of the most frequent adverse drug reactions and interactions whose degree of causality was determined by applying the modified algorithm of Karch-Lasagna, used in the World Health Organization voluntary reporting system of adverse drug reactions. Results: One hundred twenty-six patients (16% of total admissions) received diuretic therapy. Of these, 71% were analyzed; information in the medical records was incomplete for the rest (29%). Fifty-one percent of the patients were more than 60 years old. The most frequent admission diagnoses were cardiovascular (51.5%), followed by digestive (16.7%) diseases. A total of 134 cardiac symptoms was seen in 50 patients. The most notable were acute pulmonary edema (26%), ischemic cardiopathy (12%), and cardiogenic shock (8%). Most patients receiving diuretic therapy (47.3%) were admitted to the internal medicine service. The most-prescribed diuretic was furosemide (59%), followed by spironolactone (27%). The combined use of furosemide and spironolactone occurred in all but 1 of the patients with hepatic ascites (92%), whereas in those with CHF the figure for the combined use of furosemide and spironolactone fell to 38% (p = 0.001). In 63% of the patients with ascites, the spironolactone dosage was changed in the first 48 hours of treatment. There was a high percentage of deaths (21%) in the study patients. Conclusions: Therapeutic strategy often does not follow the guidelines laid down in the standards of reference on diuretic use in serious CHF and/or ascites in this institution.

scholarly journals A study of adverse drug reactions in pediatric patients

2011 ◽  
Vol 2 (4) ◽  
pp. 277 ◽  
Author(s):  
R Priyadharsini ◽  
C Adithan ◽  
FirojKumar Sahoo ◽  
A Surendiran ◽  
S Sreenivasan
Keyword(s):  
Adverse Drug Reactions ◽  
Pediatric Patients ◽  
Drug Reactions

Admissions to a University Hospital for Adverse Drug Reactions and Patient’s Interruption of Treatment

Drug Safety ◽  
2007 ◽  
Vol 30 (10) ◽  
pp. 919-990
Author(s):  
G Giachetto ◽  
A Danza ◽  
L Lucas ◽  
F Cristiani ◽  
L Cuñetti ◽  
...  
Keyword(s):  
Adverse Drug Reactions ◽  
University Hospital ◽  
Drug Reactions

scholarly journals Cutaneous Adverse Drug Reactions Seen at a University Hospital Department of Dermatology

2006 ◽  
Vol 86 (6) ◽  
pp. 523-527 ◽  
Author(s):  
JE Borch ◽  
KE Andersen ◽  
C Bindslev-Jensen
Keyword(s):  
Adverse Drug Reactions ◽  
University Hospital ◽  
Drug Reactions ◽  
Hospital Department

scholarly journals Metamizole Use in Children: Analysis of Drug Utilisation and Adverse Drug Reactions at a German University Hospital between 2015 and 2020

2021 ◽  
Author(s):  
Julia Zahn ◽  
Sonja Eberl ◽  
Wolfgang Rödle ◽  
Wolfgang Rascher ◽  
Antje Neubert ◽  
...  
Keyword(s):  
Adverse Drug Reactions ◽  
Drug Utilisation ◽  
University Hospital ◽  
Drug Reactions
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