Specific immunotherapy in the complex treatment of ovarian cancer

The article is devoted to the search for new solutions in the field of treatment of malignant ovarian tumors and, in particular, new approaches for overcoming immune resistance in a complex method of therapy. The experience of treating this pathology with an original method of postoperative immunotherapy using autologous immunomodulators, which, due to its simplicity and relatively low cost, should be widely used in gynecological oncology, is considered.

Building a Personalized Medicine Infrastructure for Gynecological Oncology Patients in a High-Volume Hospital

Gynecological cancers require complex intervention since patients have specific needs to be addressed. Centralization to high-volume centers improves the oncological outcomes of patients with gynecological cancers. Research in gynecological oncology is increasing thanks to modern technologies, from the comprehensive molecular characterization of tumors and individual pathophenotypes. Ongoing studies are focusing on personalizing therapies by integrating information across genomics, proteomics, and metabolomics with the genetic makeup and immune system of the patient. Hence, several challenges must be faced to provide holistic benefit to the patient. Personalized approaches should also recognize the unmet needs of each patient to successfully deliver the promise of personalized care, in a multidisciplinary effort. This may provide the greatest opportunity to improve patients’ outcomes. Starting from a narrative review on gynecological oncology patients’ needs, this article focuses on the experience of building a research and care infrastructure for personalized patient management.