Predicting membrane protein types by fusing composite protein sequence features into pseudo amino acid composition

2011 ◽  
Vol 271 (1) ◽  
pp. 10-17 ◽  
Author(s):  
Maqsood Hayat ◽  
Asifullah Khan
Keyword(s):  
Amino Acid ◽  
Membrane Protein ◽  
Amino Acid Composition ◽  
Acid Composition ◽  
Protein Sequence ◽  
Pseudo Amino Acid Composition ◽  
Sequence Features

scholarly journals Improved Machine Learning using Adaptive Boosting algorithm in Membrane Protein Prediction

2019 ◽  
Vol 8 (12) ◽  
pp. 3131-3137
Keyword(s):  
Feature Extraction ◽  
Amino Acid ◽  
Membrane Protein ◽  
Amino Acid Composition ◽  
Acid Composition ◽  
Extraction Method ◽  
Ensemble Classifiers ◽  
Pseudo Amino Acid Composition ◽  
Adaptive Boosting ◽  
Feature Extraction Method

Membrane protein are very important and play significantly in the field of biology and medicine. The main purpose is to find suitable features of a membrane protein. Various features extraction methods are use to find membrane protein and their types. PseAAC (Pseudo Amino Acid Composition) is a one of the feature extraction method which was used to find the localization of the protein, which helps in the detection of membrane types. Therefore, in this study, a novel feature extraction method which is an integration of the pseudo amino acid composition integer values mapped in discrete sequence numbers in a matrix. The proposed scheme avoids biasing among the different membrane proteins and their types. Decision making for predicting the identification of membrane protein types was performed using an algorithm framework to improve the learning accuracy, by putting the training samples weights in the learning process of AdaBoost. The performance of different ensemble classifiers such as Random Forest, AdaBoost, is analyzed. The best accuracy achieved is 91.50% for with the Matthews correlation coefficient is 83.0%, and Cohen’s Kappa value is 82.7%

Sign in / Sign up

Export Citation Format

Share Document