P3.03-022 Serum CEA, VEGF and MMP-7 in Patients with Malignant Pleural Effusion. A Prospective Study with Logistic Regression Analysis of Accuracy

Objectives The purpose of this study was to identify the risk factors for postoperative transient hypoparathyroidism in a group of patients undergoing thyroid surgery. Study Design A prospective study was conducted on 604 patients undergoing thyroid surgery. Subjects and Methods Gender, final diagnosis, extent of resection, biology of pathology, intrathoracic involvement, surgery for recurrent multinodular goiter, and presence and number of parathyroid glands in a surgical specimen were analyzed as risk factors for postoperative transient hypoparathyroidism. The chi-square test and a logistic regression analysis were applied. RESULTS: On logistic regression analysis, only the extent of surgery constituted an independent variable for transient hypoparathyroidism ( P = 0.001). Conclusion The extent of surgery to central and/or lateral neck lymph nodes is responsible for a high rate of transient hypoparathyroidism owing to a high probability of unplanned parathyroidectomy or parathyroid gland devascularization.

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The efficacy of doxycycline as a pleural sclerosing agent in malignant pleural effusion: A prospective study

Respirology ◽

10.1111/j.1440-1843.1996.tb00013.x ◽

1996 ◽

Vol 1 (1) ◽

pp. 69-72 ◽

Cited By ~ 18

Author(s):

C PULSIRIPUNYA ◽

P YOUNGCHAIYUD ◽

R PUSHPAKOM ◽

N MARANETRA ◽

A NANA ◽

...

Keyword(s):

Pleural Effusion ◽

Prospective Study ◽

Malignant Pleural Effusion ◽

Sclerosing Agent ◽

A Prospective Study

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LENT Score: Predicting the Survival of Malignant Pleural Effusion – A Prospective Study of Three Years

Archivos de Bronconeumología (English Edition) ◽

10.1016/j.arbr.2020.01.004 ◽

2020 ◽

Vol 56 (7) ◽

pp. 465-466

Author(s):

Sara Raimundo ◽

Ana Isabel Loureiro ◽

Fortunato Vieira ◽

Ana Fernandes

Keyword(s):

Pleural Effusion ◽

Prospective Study ◽

Malignant Pleural Effusion ◽

A Prospective Study

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LENT Score: Predicting the Survival of Malignant Pleural Effusion – A Prospective Study of Three Years

Archivos de Bronconeumología ◽

10.1016/j.arbres.2020.01.004 ◽

2020 ◽

Vol 56 (7) ◽

pp. 465-466

Author(s):

Sara Raimundo ◽

Ana Isabel Loureiro ◽

Fortunato Vieira ◽

Ana Fernandes

Keyword(s):

Pleural Effusion ◽

Prospective Study ◽

Malignant Pleural Effusion ◽

A Prospective Study

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The evaluation of factors affecting antibody response after administration of the BNT162b2 vaccine: a prospective study in Japan

PeerJ ◽

10.7717/peerj.12316 ◽

2021 ◽

Vol 9 ◽

pp. e12316

Author(s):

Toshiya Mitsunaga ◽

Yuhei Ohtaki ◽

Yutaka Seki ◽

Masakata Yoshioka ◽

Hiroshi Mori ◽

...

Keyword(s):

Logistic Regression ◽

Regression Analysis ◽

Antibody Response ◽

Prospective Study ◽

Antibody Titer ◽

Logistic Regression Analysis ◽

Multivariate Logistic Regression Analysis ◽

Antibody Test ◽

Antibody Responses ◽

Multivariate Logistic Regression

The aim of this study was to evaluate the antibody reaction after administration of the BNT162b2 vaccine, and to reveal the factors that affect antibody production. This prospective study was carried out in the Association of EISEIKAI Medical and Healthcare Corporation Minamitama Hospital, in Tokyo, Japan, from April 15, 2021 to June 09, 2021. All our hospital’s workers who were administered the BNT162b2 vaccine as part of a routine program were included in this study. We calculated the anti-SARS-CoV-2 spike-specific antibody titter (1) before vaccination, (2) 7 to 20 days after the first vaccination, and (3) A total of 7 to 20 days after the second vaccination. The low-antibody titer group (LABG) was defined as the group having less than 25 percentiles of antibody titer. Univariate and Multivariate logistic regression analysis were performed to ascertain the effects of factors on the likelihood of LABG. A total of 374 participants were eventually included in our study, and they were divided into 94 LABG and 280 non-LABG. All samples showed significant antibody elevation in the second antibody test, with a mean value of 3,476 U/mL. When comparing the LABG and non-LABG groups, the median age, blood sugar, and HbA1c were significantly higher in the LABG group. The rates of participants with low BMI (<18.5) and high BMI (>30) were significantly higher in the LABG group. The proportion of chronic lung disease, hypertension, diabetes, dyslipidemia, autoimmune disease, and cancer were significantly higher in the LABG group. Although there was no significant difference confirmed with respect to the exercise hours per day, the proportion of participants that did not perform outdoor exercises was significantly higher in the LABG group. The time interval between the second vaccination and the second antibody test, and between the first and the second vaccination was significantly longer in the non-LABG group. In the multivariate logistic regression analysis, older than 60 years, the past history of hypertension, HbA1c higher than 6.5%, and lack of outdoor exercises were significant suppressors of antibody responses, whereas the length of days from the first to the second vaccination longer than 25 days promoted a significant antibody response. Again, our single-center study demonstrates that older than 60 years, hypertension, HbA1c higher than 6.5%, and lack of outdoor exercises were significant suppressors of antibody responses, whereas the length of days from the first to the second vaccination longer than 25 days promoted a significant antibody response. Evidence from multi-center studies is needed to develop further vaccination strategies.

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Use of T-SPOT.TB for the diagnosis of unconventional pleural tuberculosis is superior to ADA in high prevalence areas: A prospective analysis of 601 cases

10.21203/rs.2.22951/v3 ◽

2020 ◽

Author(s):

Xinting Yang ◽

jing zhang ◽

Qingtao Liang ◽

Liping Pan ◽

Hongfei Duan ◽

...

Keyword(s):

Risk Factors ◽

Logistic Regression ◽

Regression Analysis ◽

Pleural Effusion ◽

Logistic Regression Analysis ◽

Mononuclear Cells ◽

Multivariate Logistic Regression Analysis ◽

Interferon Gamma Release Assay ◽

Diagnostic Efficiency ◽

Diagnostic Efficacy

Abstract BACKGROUND: Tuberculous pleural effusion (TPE) is the most common extrapulmonary manifestation which still has lasting effect on lung function, however conventional diagnostic tests for TPE register multiple limitations. OBJECTIVES: This study aims to investigate diagnostic efficacy of the interferon gamma release assay (IGRA: T-SPOT.TB) in TPE patients of different characteristics comparing to adenosine deaminase (ADA), in order to clarify its appropriate setting in clinical diagnosis.METHODS: We performed a prospective, single-centre study including all suspected pleural effusion patients consecutively from June 2015 to October 2018. By using receiver operating characteristic (ROC) curves, technical cut-offs for all enrolled participants were determined, and the utility of IGRA for pleural fluid (PF) was analysed. We obtained the independent risk factors using logistic regression analysis for TPE and evaluated the performance of the T-SPOT assay stratified by risk factors in comparison to ADA.RESULTS: A total of 601 individuals was consecutively recruited. The maximum of early secretory antigenic target-6 (ESAT-6) and culture filtrate protein-10 (CFP-10) in the PF T-SPOT assay had the best diagnostic efficiency in our study, with a sensitivity of 83.0% and a specificity of 83.1%. The corresponding cut-off value was 466 SFCs/106 mononuclear cells, which was equal to ADA (0.885 vs 0.887, P=0.957) and superior to PB. Among the TPE patients with low ADA (<40 IU/L), the sensitivity and specificity of PF T-SPOT were still 87.9% and 90.5%, respectively. The utility of ADA was negatively related to increasing age, but the PF T-SPOT test had a steady performance at all ages. Age (<45 yrs; odds ratio (OR) = 5.61, 95% confidence interval (CI) 3.59-8.78; P<0.001), gender (male; OR = 2.68, 95% CI 1.75-2.88; P<0.001) and body mass index (BMI) (<22; OR = 1.93, 95% CI 1.30-2.88; P=0.001) were independently associated with the risk of TB by multivariate logistic regression analysis. Notably, when stratified by risk factor, the sensitivity of PF T-SPOT was superior to the sensitivity (76.5% vs. 23.5%, P=0.016) for ADA and had noninferior specificity (84.4% vs. 96.9%, P=0.370).CONCLUSIONS: In conclusion, the overall potency of the PF T-SPOT assay is equal to that of ADA for diagnosing TPE. In addition, the PF T-SPOT assay can effectively discriminate TPE patients whose ADA is lower than 40 IU/L and is extremely superior to ADA in unconventional TPE patients (age≥45 yrs, female or BMI≥22). The PF T-SPOT assay is an excellent choice to supplement ADA to diagnose TPE.

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Use of T-SPOT.TB for the diagnosis of unconventional pleural tuberculosis is superior to ADA in high prevalence areas: A prospective analysis of 601 cases

10.21203/rs.2.22951/v5 ◽

2020 ◽

Author(s):

Xinting Yang ◽

jing zhang ◽

Qingtao Liang ◽

Liping Pan ◽

Hongfei Duan ◽

...

Keyword(s):

Risk Factors ◽

Logistic Regression ◽

Regression Analysis ◽

Pleural Effusion ◽

Logistic Regression Analysis ◽

Mononuclear Cells ◽

Multivariate Logistic Regression Analysis ◽

Interferon Gamma Release Assay ◽

Diagnostic Efficiency ◽

Diagnostic Efficacy

Abstract BACKGROUND: Tuberculous pleural effusion (TPE) is the most common extrapulmonary manifestation and may have lasting effect on lung function. However conventional diagnostic tests for TPE register multiple limitations. This study estimates diagnostic efficacy of the interferon gamma release assay (IGRA: T-SPOT.TB) in TPE patients of different characteristics.METHODS: We performed a prospective, single-centre study including all suspected pleural effusion patients consecutively enrolled from June 2015 to October 2018. Through receiver operating characteristic (ROC) curves, technical cut-offs and the utility of T-SPOT on pleural fluid (PF) were determined and analysed. Logistic regression analysis was performed to obtain the independent risk factors for TPE, and evaluated the performance of the T-SPOT assay stratified by risk factors in comparison to ADA.RESULTS: A total of 601 individuals were consecutively recruited. The maximum spot-forming cells (SFCs) of early secretory antigenic target-6 (ESAT-6) and culture filtrate protein-10 (CFP-10) in the PF T-SPOT assay had the best diagnostic efficiency in our study, which was equal to ADA (0.885 vs 0.887, P=0.957) and superior to peripheral blood (PB), with a sensitivity of 83.0% and a specificity of 83.1% (The cut-off value was 466 SFCs/106 mononuclear cells). Among the TPE patients with low ADA (<40 IU/L), the sensitivity and specificity of PF T-SPOT were still 87.9% and 90.5%, respectively. The utility of ADA was negatively related to increasing age, but the PF T-SPOT test had a steady performance at all ages. Age (<45 yrs; odds ratio (OR) = 5.61, 95% confidence interval (CI) 3.59-8.78; P<0.001), gender (male; OR = 2.68, 95% CI 1.75-2.88; P<0.001) and body mass index (BMI) (<22; OR = 1.93, 95% CI 1.30-2.88; P=0.001) were independently associated with the risk of TB by multivariate logistic regression analysis. Notably, when stratified by risk factor, the sensitivity of PF T-SPOT was superior to the sensitivity for ADA (76.5% vs. 23.5%, P=0.016) and had noninferior specificity (84.4% vs. 96.9%, P=0.370).CONCLUSIONS: In conclusion, the PF T-SPOT assay can effectively discriminate TPE patients whose ADA is lower than 40 IU/L and is superior to ADA in unconventional TPE patients (age≥45 yrs, female or BMI≥22). The PF T-SPOT assay is an excellent choice to supplement ADA to diagnose TPE.

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The utility of T-SPOT.TB for the diagnosis unconventional pleural tuberculosis is superior to ADA in high prevalence: A perspective analysis of 601 cases

10.21203/rs.2.22951/v1 ◽

2020 ◽

Author(s):

Xinting Yang ◽

jing zhang ◽

Qingtao Liang ◽

Liping Pan ◽

Hongfei Duan ◽

...

Keyword(s):

Risk Factors ◽

Logistic Regression ◽

Regression Analysis ◽

Pleural Effusion ◽

Logistic Regression Analysis ◽

Multivariate Logistic Regression Analysis ◽

World Health ◽

Interferon Gamma Release Assay ◽

Diagnostic Efficiency ◽

Diagnostic Efficacy

Abstract BACKGROUND Recently, Interferon Gamma Release Assay (IGRA) is still controversial in differentiating tuberculous pleural effusion (TPE), through recommended by World Health Organization (WHO )for identification of latent tuberculosis infection. OBJECTIVES Aim to qualify the diagnostic efficacy for TPE by IGRA in comparison to Adenosine deaminase(ADA), to clarify its appropriate scene in clinical diagnosis. METHODS A prospective, single-centre study including all suspected pleural effusion patients consecutively from June 2015 to October 2018. Through receiver operating characteristic (ROC) curves, all enrolled participants were determined technical cut-off and the utility of IGRA(T-SPOT)for pleural fluid(PF). Obtain the independent risk factors by logistic regression analysis for TPE, and evaluate the performance of T-SPOT stratified by risk factors, in comparison to ADA. RESULTS A total of 601 individuals were consecutively recruited. The maximum of early secretory antigenic target-6 (ESAT-6) and culture filtrate protein-10 (CFP-10) in PF T-SPOT had the best diagnostic efficiency in our study, with a sensitivity of 83.0% and a specificity of 83.1%, corresponding cut-off value is 466, which was equal to ADA(0.885 vs 0.887, P=0.957) and superior than in PB; Among the TPE patients with low ADA(<40 IU/L), the sensitivity and specificity of PF T-SPOT was still 87.9%, 90.5% respectively. The utility of ADA was negative related to age ascents, but PF T-SPOT had steady performance at any age-stage. The age (<45 yrs; odds ratio (OR) 5.61), gender (male; OR 2.7) and body mass index (BMI)(<22; OR 1.93) was independently associated with the risk of TB by multivariate logistic regression analysis. Stratified by risk factors, notably the PF T-SPOT had superior sensitivity(76.5% vs. 23.5%,P=0.016) than ADA meanwhile had the non-inferior specificity(84.4% vs. 96.9%, P=0.370). CONCLUSIONS In conclusion, the overall potency of PF T-SPOT assay is equal to ADA for diagnosing TPE. In addition, PF T-SPOT can effectively discriminate the TPE patients whose ADA lower than 40IU/L, and extremely superior to ADA in unconventional TPE patients(age>45yrs, female or BMI<22). PF T-SPOT assay is an extremely good choice to supplement ADA to diagnose TPE.

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Use of T-SPOT.TB for the diagnosis of unconventional pleural tuberculosis is superior to ADA in high prevalence areas: a prospective analysis of 601 cases

BMC Infectious Diseases ◽

10.1186/s12879-020-05676-2 ◽

2021 ◽

Vol 21 (1) ◽

Author(s):

Xinting Yang ◽

Jing Zhang ◽

Qingtao Liang ◽

Liping Pan ◽

Hongfei Duan ◽

...

Keyword(s):

Risk Factors ◽

Logistic Regression ◽

Regression Analysis ◽

Pleural Effusion ◽

Logistic Regression Analysis ◽

Mononuclear Cells ◽

Multivariate Logistic Regression Analysis ◽

Interferon Gamma Release Assay ◽

Diagnostic Efficiency ◽

Diagnostic Efficacy

Abstract Background Tuberculous pleural effusion (TPE) is the most common extrapulmonary manifestation and may have lasting effect on lung function. However conventional diagnostic tests for TPE register multiple limitations. This study estimates diagnostic efficacy of the interferon gamma release assay (IGRA: T-SPOT.TB) in TPE patients of different characteristics. Methods We performed a prospective, single-centre study including all suspected pleural effusion patients consecutively enrolled from June 2015 to October 2018. Through receiver operating characteristic (ROC) curves, technical cut-offs and the utility of T-SPOT on pleural fluid (PF) were determined and analysed. Logistic regression analysis was performed to obtain the independent risk factors for TPE, and evaluated the performance of the T-SPOT assay stratified by risk factors in comparison to ADA. Results A total of 601 individuals were consecutively recruited. The maximum spot-forming cells (SFCs) of early secretory antigenic target-6 (ESAT-6) and culture filtrate protein-10 (CFP-10) in the PF T-SPOT assay had the best diagnostic efficiency in our study, which was equal to ADA (0.885 vs 0.887, P = 0.957) and superior to peripheral blood (PB), with a sensitivity of 83.0% and a specificity of 83.1% (The cut-off value was 466 SFCs/106 mononuclear cells). Among the TPE patients with low ADA (< 40 IU/L), the sensitivity and specificity of PF T-SPOT were still 87.9 and 90.5%, respectively. The utility of ADA was negatively related to increasing age, but the PF T-SPOT test had a steady performance at all ages. Age (< 45 yrs.; odds ratio (OR) = 5.61, 95% confidence interval (CI) 3.59–8.78; P < 0.001), gender (male; OR = 2.68, 95% CI 1.75–2.88; P < 0.001) and body mass index (BMI) (< 22; OR = 1.93, 95% CI 1.30–2.88; P = 0.001) were independently associated with the risk of TB by multivariate logistic regression analysis. Notably, when stratified by risk factor, the sensitivity of PF T-SPOT was superior to the sensitivity for ADA (76.5% vs. 23.5%, P = 0.016) and had noninferior specificity (84.4% vs. 96.9%, P = 0.370). Conclusions In conclusion, the PF T-SPOT assay can effectively discriminate TPE patients whose ADA is lower than 40 IU/L and is superior to ADA in unconventional TPE patients (age ≥ 45 yrs., female or BMI ≥ 22). The PF T-SPOT assay is an excellent choice to supplement ADA to diagnose TPE.

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The utility of T-SPOT.TB for the diagnosis unconventional pleural tuberculosis is superior to ADA in high prevalence: A perspective analysis of 601 cases

10.21203/rs.2.22951/v2 ◽

2020 ◽

Author(s):

Xinting Yang ◽

jing zhang ◽

Qingtao Liang ◽

Liping Pan ◽

Hongfei Duan ◽

...

Keyword(s):

Risk Factors ◽

Logistic Regression ◽

Regression Analysis ◽

Pleural Effusion ◽

Logistic Regression Analysis ◽

Mononuclear Cells ◽

Multivariate Logistic Regression Analysis ◽

World Health ◽

Interferon Gamma Release Assay ◽

Diagnostic Efficiency

Abstract BACKGROUND: Interferon Gamma Release Assay (IGRA) is still controversial in differentiating tuberculous pleural effusion (TPE), through recommended by World Health Organization (WHO) for identification of latent tuberculosis infection. OBJECTIVES: Aim to in comparison to Adenosine deaminase (ADA), evaluate the IGRA (T-SPOT.TB) diagnostic efficacy for TPE patients of different characteristics, to clarify its appropriate scene in clinical diagnosis. METHODS: A prospective, single-centre study including all suspected pleural effusion patients consecutively from June 2015 to October 2018. Through receiver operating characteristic (ROC) curves, all enrolled participants were determined technical cut-off and the utility of IGRA for pleural fluid (PF). Obtain the independent risk factors by logistic regression analysis for TPE, and evaluate the performance of T-SPOT stratified by risk factors, in comparison to ADA. RESULTS: A total of 601 individuals were consecutively recruited. The maximum of early secretory antigenic target-6 (ESAT-6) and culture filtrate protein-10 (CFP-10) in PF T-SPOT had the best diagnostic efficiency in our study, with a sensitivity of 83.0% and a specificity of 83.1%, corresponding cut-off value is 466 SFCs/10 6 mononuclear cells, which was equal to ADA (0.885 vs 0.887, P=0.957) and superior than in PB; Among the TPE patients with low ADA(<40 IU/L), the sensitivity and specificity of PF T-SPOT was still 87.9%, 90.5% respectively. The utility of ADA was negative related to age ascents, but PF T-SPOT had steady performance at any age-stage. The age (<45 yrs; odds ratio (OR) = 5.61), gender (male; OR = 2.7) and body mass index (BMI) (<22; OR = 1.93) was independently associated with the risk of TB by multivariate logistic regression analysis. Stratified by risk factors, notably the PF T-SPOT had superior sensitivity (76.5% vs. 23.5%, P =0.016) than ADA meanwhile had the non-inferior specificity (84.4% vs. 96.9%, P =0.370). CONCLUSIONS: In conclusion, the overall potency of PF T-SPOT assay is equal to ADA for diagnosing TPE. In addition, PF T-SPOT can effectively discriminate the TPE patients whose ADA lower than 40 IU/L, extremely superior to ADA in unconventional TPE patients (age>45yrs, female or BMI≧22). PF T-SPOT assay is an extremely good choice to supplement ADA to diagnose TPE.

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