scholarly journals P2.06-010 Association of Vitamin D Receptor BsmI Polymorphism with Lung Cancer Risk: Evidence from a Meta-Analysis

2017 ◽  
Vol 12 (11) ◽  
pp. S2415
Author(s):  
A. Zhong ◽  
M. Shi
Keyword(s):  
Lung Cancer ◽  
Vitamin D ◽  
Cancer Risk ◽  
Vitamin D Receptor ◽  
Lung Cancer Risk ◽  
Meta Analysis ◽  
Bsmi Polymorphism

The Association of Vitamin D Receptor Gene Polymorphism with Lung Cancer Risk: An Update Meta-analysis

2019 ◽  
Vol 21 (10) ◽  
pp. 704-710 ◽  
Author(s):  
Zhi-Hong Yu ◽  
Miao Chen ◽  
Qing-Qian Zhang ◽  
Xun Hu
Keyword(s):  
Lung Cancer ◽  
Vitamin D ◽  
Genetic Polymorphism ◽  
Cancer Risk ◽  
Vitamin D Receptor ◽  
Lung Cancer Risk ◽  
Meta Analysis ◽  
Receptor Gene ◽  
Vdr Gene ◽  
Increased Risk

The association between vitamin D receptor (VDR) genetic polymorphism and lung cancer risk has been evaluated by the previous meta-analyses. Due to the emergence of novel studies and inappropriate inclusion of overlapping populations, an updated meta-analysis on recent evidences is necessarily needed. We comprehensively searched databases of PubMed, Web of Science and Chinese National Knowledge Infrastructure and finally obtained 7 eligible studies according to the inclusion criteria. Four positions on VDR gene, namely ApaI (rs7975232), BsmI (rs1544410), FokI (rs10735810) and TaqI (rs731236), were considered in this investigation. Data pooling found no significant association of lung cancer risk with ApaI or FokI. In contrast, it was indicated that the BsmI A allele was negatively related to the lung cancer risk, compared with the G allele (OR = 0.51, 95% CI = 0.33-0.79). Individuals with BsmI AA (OR = 0.53, 95% CI = 0.26-1.11) and AG genotypes (OR = 0.46, 95% CI = 0.30−0.71) showed decreased risk of lung cancer, compared with those of GG genotype. Regarding the TaqI polymorphism, the T allele carriers were at increased risk of lung cancer (OR = 1.25, 95% CI = 1.04-1.50). Compared with the TaqI TC+CC genotype, the TT genotype was positively associated with lung cancer risk (OR = 1.42, 95% CI = 1.11-1.82). No publication bias was identified in any of the analysis. In conclusion, VDR genetic polymorphism may be correlated to lung cancer risk. Given limited number of the included studies, more observations are warranted to draw a safer conclusion.

Association of vitamin D receptor FokI and ApaI polymorphisms with lung cancer risk in Tunisian population

2014 ◽  
Vol 41 (10) ◽  
pp. 6545-6553 ◽  
Author(s):  
Wajih Kaabachi ◽  
Safa Kaabachi ◽  
Ahlem Rafrafi ◽  
Amira ben Amor ◽  
Kalthoum Tizaoui ◽  
...  
Keyword(s):  
Lung Cancer ◽  
Vitamin D ◽  
Cancer Risk ◽  
Vitamin D Receptor ◽  
Lung Cancer Risk ◽  
Tunisian Population

scholarly journals Meta-analysis of the correlation between vitamin D and lung cancer risk and outcomes

Oncotarget ◽  
2017 ◽  
Vol 8 (46) ◽  
pp. 81040-81051 ◽  
Author(s):  
Jian Liu ◽  
Yongquan Dong ◽  
Chao Lu ◽  
Yina Wang ◽  
Ling Peng ◽  
...  
Keyword(s):  
Lung Cancer ◽  
Vitamin D ◽  
Cancer Risk ◽  
Lung Cancer Risk ◽  
Meta Analysis

BsmI polymorphism of vitamin D receptor gene and cancer risk: A comprehensive meta-analysis

2014 ◽  
Vol 769 ◽  
pp. 17-34 ◽  
Author(s):  
Sara Raimondi ◽  
Elena Pasquali ◽  
Patrizia Gnagnarella ◽  
Davide Serrano ◽  
Davide Disalvatore ◽  
...  
Keyword(s):  
Vitamin D ◽  
Cancer Risk ◽  
Vitamin D Receptor ◽  
Meta Analysis ◽  
Receptor Gene ◽  
Vitamin D Receptor Gene ◽  
Bsmi Polymorphism

Polymorphisms in the vitamin D receptor gene and the lung cancer risk

Tumor Biology ◽  
2013 ◽  
Vol 35 (2) ◽  
pp. 1323-1330 ◽  
Author(s):  
Yingjv Fu ◽  
Junrui Li ◽  
Yuanyue Zhang
Keyword(s):  
Lung Cancer ◽  
Vitamin D ◽  
Cancer Risk ◽  
Vitamin D Receptor ◽  
Lung Cancer Risk ◽  
Receptor Gene ◽  
Vitamin D Receptor Gene

scholarly journals Vitamin D and Lung Cancer Risk: A Comprehensive Review and Meta-Analysis

2015 ◽  
Vol 36 (1) ◽  
pp. 299-305 ◽  
Author(s):  
Liqun Zhang ◽  
Sihai Wang ◽  
Xiaoyu Che ◽  
Xuehui Li
Keyword(s):  
Lung Cancer ◽  
Vitamin D ◽  
Cancer Risk ◽  
Lung Cancer Risk ◽  
Meta Analysis ◽  
Serum Vitamin ◽  
Comprehensive Review ◽  
Serum Vitamin D ◽  
Vitamin D Intake ◽  
Vitamin D Levels

Background/Aim: Vitamin D has been suggested to have important roles against cancer development. There were several published studies on the association between vitamin D and lung cancer risk, but not conclusive results were available. Methods: To clarify the role of vitamin D in lung carcinogenesis, we performed a comprehensive review of the literature and a meta-analysis to evaluate the association of serum vitamin D levels and dietary vitamin D intake with lung cancer risk. Twelve studies (9 prospective cohort and 3 nested case-control studies) with a total of 288,778 individuals were included. The summary relative risk (RR) with 95% confidence interval (CI) was used to assess lung cancer risk. Results: Meta-analysis of total 12 studies showed that RR for the association of high vitamin D status with lung cancer was 0.84 (95%CI 0.78-0.90, P < 0.001). The RR of lung cancer for the highest versus lowest quintile of serum vitamin D levels was 0.83 (95%CI 0.77-0.90, P < 0.001). The RR of lung cancer for the highest versus lowest quintile of vitamin D intake was 0.89 (95%CI 0.74-1.06, P = 0.184). Conclusion: Current data suggest an inverse association between serum vitamin D and lung cancer risk. Further studies are needed to investigate the effect of vitamin D intake on lung cancer risk and to evaluate whether vitamin D supplementation can prevent lung cancer.

scholarly journals Associations between female lung cancer risk and sex steroid hormones: a systematic review and meta-analysis of the worldwide epidemiological evidence on endogenous and exogenous sex steroid hormones

BMC Cancer ◽  
2021 ◽  
Vol 21 (1) ◽  
Author(s):  
Hui Zeng ◽  
Zhuoyu Yang ◽  
Jiang Li ◽  
Yan Wen ◽  
Zheng Wu ◽  
...  
Keyword(s):  
Lung Cancer ◽  
Cancer Risk ◽  
Steroid Hormones ◽  
Lung Cancer Risk ◽  
Meta Analysis ◽  
Sex Steroid Hormones ◽  
Sex Steroid ◽  
Sex Steroid Hormone ◽  
Hormone Exposure ◽  
Female Lung Cancer

Abstract Background Published findings suggest sex differences in lung cancer risk and a potential role for sex steroid hormones. Our aim was to perform a meta-analysis to investigate the effects of sex steroid hormone exposure specifically on the risk of lung cancer in women. Methods The PubMed, MEDLINE, Web of Science, and EMBASE databases were searched. The pooled odds ratios (ORs) and 95% confidence intervals (95% CIs) for female lung cancer risk associated with sex steroid hormones were calculated overall and by study design, publication year, population, and smoking status. Sensitivity analysis, publication bias, and subgroup analysis were performed. Results Forty-eight studies published between 1987 and 2019 were included in the study with a total of 31,592 female lung cancer cases and 1,416,320 subjects without lung cancer. Overall, higher levels of sex steroid hormones, both endogenous (OR: 0.92, 95% CI: 0.87–0.98) and exogenous (OR: 0.86, 95% CI: 0.80–0.93), significantly decreased the risk of female lung cancer by 10% (OR: 0.90, 95% CI: 0.86–0.95). The risk of lung cancer decreased more significantly with a higher level of sex steroid hormones in non-smoking women (OR: 0.88, 95% CI: 0.78–0.99) than in smoking women (OR: 0.98, 95% CI: 0.77–1.03), especially in Asia women (OR: 0.84, 95% CI: 0.74–0.96). Conclusions Our meta-analysis reveals an association between higher levels of sex steroid hormone exposure and the decreased risk of female lung cancer. Surveillance of sex steroid hormones might be used for identifying populations at high risk for lung cancer, especially among non-smoking women.

Sign in / Sign up

Export Citation Format

Share Document