scholarly journals Evaluating the clinical translational relevance of animal models for limbal stem cell deficiency: A systematic review

2021 ◽  
Author(s):  
Naomi C. Delic ◽  
Jessie R. Cai ◽  
Stephanie L. Watson ◽  
Laura E. Downie ◽  
Nick Di Girolamo
Keyword(s):  
Systematic Review ◽  
Stem Cell ◽  
Animal Models ◽  
Limbal Stem Cell Deficiency ◽  
Limbal Stem Cell

Keratolimbal allograft for limbal stem cell deficiency after severe corneal chemical injury: a systematic review

2017 ◽  
Vol 102 (8) ◽  
pp. 1114-1121 ◽  
Author(s):  
Swapna S Shanbhag ◽  
Hajirah N Saeed ◽  
Eleftherios I Paschalis ◽  
James Chodosh
Keyword(s):  
Systematic Review ◽  
Stem Cell ◽  
Best Practice ◽  
Limbal Stem Cell Deficiency ◽  
Cochrane Library ◽  
Systematic Review Methodology ◽  
Chemical Injury ◽  
Keratolimbal Allograft ◽  
Limbal Stem Cell

PurposeTo review the published literature on outcomes of keratolimbal allograft (KLAL) for the surgical treatment of limbal stem cell deficiency (LSCD) and corneal blindness after severe corneal chemical injury.MethodsLiterature searches were conducted in the following electronic databases: MEDLINE, EMBASE, Science Citation Index, CINAHL, LILACS and the Cochrane Library. Standard systematic review methodology was applied. The main outcome measure was the proportion of eyes with best-corrected visual acuity (BCVA) ≥20/200 at last follow-up. Other measures of allograft success were also collected.ResultsWe identified six reports in which KLAL outcomes in the eyes after chemical injury could be distinguished. There were no randomised controlled studies. The outcomes of KLAL in 36 eyes of 33 patients were analysed. One study with seven eyes did not specify KLAL follow-up specific to chemical injury. Median postoperative follow-up for the other 29 eyes in 26 patients was 42 months (range 6.2–114 months). In the same 29 eyes, 69% (20/29) had BCVA ≥20/200 at the last follow-up examination. Eighty-nine per cent of all eyes (32/36) underwent penetrating keratoplasty simultaneous or subsequent to KLAL.ConclusionsThe number of studies where outcomes of KLAL in eyes with severe corneal chemical injury could be discerned was limited, and variability was observed in outcome reporting. The quality of evidence to support the use of KLAL in LSCD in severe chemical corneal burns was low. Standardisation and longer follow-up are needed to better define evidence-based best practice when contemplating surgical intervention for blindness after corneal chemical injury.PROSPERO registration numberCRD42017054733.

Boston keratoprosthesis type 1 for limbal stem cell deficiency after severe chemical corneal injury: A systematic review

2018 ◽  
Vol 16 (3) ◽  
pp. 272-281 ◽  
Author(s):  
Swapna S. Shanbhag ◽  
Hajirah N. Saeed ◽  
Eleftherios I. Paschalis ◽  
James Chodosh
Keyword(s):  
Systematic Review ◽  
Stem Cell ◽  
Limbal Stem Cell Deficiency ◽  
Boston Keratoprosthesis ◽  
Corneal Injury ◽  
Limbal Stem Cell

scholarly journals Efficacy and outcome of simple limbal epithelial transplantation for limbal stem cell deficiency verified by epithelial phenotypes integrated with clinical evaluation

2021 ◽  
Author(s):  
Pinnita Prabhasawat ◽  
Chareenun Chirapapaisan ◽  
Panotsom Ngowyutagon ◽  
Pattama Ekpo ◽  
Wimolwan Tangpagasit ◽  
...  
Keyword(s):  
Stem Cell ◽  
Clinical Evaluation ◽  
Limbal Stem Cell Deficiency ◽  
Limbal Stem Cell

Photochemical tissue bonding: A potential strategy for treating limbal stem cell deficiency

2011 ◽  
Vol 43 (5) ◽  
pp. 433-442 ◽  
Author(s):  
Chuan Gu ◽  
Tao Ni ◽  
Erol E. Verter ◽  
Robert W. Redmond ◽  
Irene E. Kochevar ◽  
...  
Keyword(s):  
Stem Cell ◽  
Limbal Stem Cell Deficiency ◽  
Limbal Stem Cell ◽  
Potential Strategy

Limbal Stem Cell Deficiency and Corneal Neovascularization

2009 ◽  
Vol 24 (3) ◽  
pp. 139-148 ◽  
Author(s):  
Pauline Lim ◽  
Thomas A. Fuchsluger ◽  
Ula V. Jurkunas
Keyword(s):  
Stem Cell ◽  
Corneal Neovascularization ◽  
Limbal Stem Cell Deficiency ◽  
Limbal Stem Cell
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