542 CHARACTERIZATION OF LUMBOSACRAL NEURAL ORGANIZATION OF MICTURITION REFLEX PATHWAYS WITH BLADDER DYSFUNCTION AFTER COMPLETE THORACIC SPINAL CORD TRANSECTION IN RATS

2013 ◽  
Vol 189 (4S) ◽  
Author(s):  
Hai-Hong Jiang ◽  
Fu-Chen Yang ◽  
Brian Balog ◽  
Kevin Li ◽  
Ching-Yi Lin ◽  
...  
Keyword(s):  
Spinal Cord ◽  
Bladder Dysfunction ◽  
Spinal Cord Transection ◽  
Thoracic Spinal Cord ◽  
Micturition Reflex ◽  
Neural Organization ◽  
Reflex Pathways ◽  
Thoracic Spinal

scholarly journals Rigid and remodelled: cerebrovascular structure and function after experimental high-thoracic spinal cord transection

2016 ◽  
Vol 594 (6) ◽  
pp. 1677-1688 ◽  
Author(s):  
A. A. Phillips ◽  
N. Matin ◽  
B. Frias ◽  
M. M. Z. Zheng ◽  
M. Jia ◽  
...  
Keyword(s):  
Spinal Cord ◽  
Structure And Function ◽  
Spinal Cord Transection ◽  
Thoracic Spinal Cord ◽  
Thoracic Spinal ◽  
And Function

Role of spinal 5-HT2receptor subtypes in quipazine-induced hindlimb movements after a low-thoracic spinal cord transection

2008 ◽  
Vol 28 (11) ◽  
pp. 2231-2242 ◽  
Author(s):  
Roth-V. Ung ◽  
Eric S. Landry ◽  
Pascal Rouleau ◽  
Nicolas P. Lapointe ◽  
Claude Rouillard ◽  
...  
Keyword(s):  
Spinal Cord ◽  
Spinal Cord Transection ◽  
Thoracic Spinal Cord ◽  
Thoracic Spinal

scholarly journals Characterization of neurological recovery following traumatic sensorimotor complete thoracic spinal cord injury

Spinal Cord ◽  
2010 ◽  
Vol 49 (3) ◽  
pp. 463-471 ◽  
Author(s):  
J Zariffa ◽  
J L K Kramer ◽  
J W Fawcett ◽  
D P Lammertse ◽  
A R Blight ◽  
...  
Keyword(s):  
Spinal Cord ◽  
Spinal Cord Injury ◽  
Neurological Recovery ◽  
Thoracic Spinal Cord ◽  
Thoracic Spinal ◽  
Cord Injury

scholarly journals Electrical activity recorded from the spinal cord in freely moving rats using a subdural bioelectronic implant

2021 ◽  
Author(s):  
Bruce C Harland ◽  
Zaid Aqrawe ◽  
Maria Vomero ◽  
Christian Boehler ◽  
Brad Raos ◽  
...  
Keyword(s):  
Spinal Cord ◽  
Hind Limb ◽  
Negative Impact ◽  
Neural Tissue ◽  
Voltage Waveform ◽  
Thoracic Spinal Cord ◽  
Thoracic Spinal ◽  
Cord Injury ◽  
Freely Moving

Bioelectronic devices have found use at the interface with neural tissue to investigate and treat nervous system disorders. Here, we present the development and characterization of a thin flexible bioelectronic implant inserted over the thoracic spinal cord in rats directly in contact with the spinal cord. There was no negative impact on hind-limb functionality nor any change in the volume or shape of the spinal cord. The bioelectronic implant was maintained in rats for a period of 3 months. We present the first subdural recordings of spinal cord activity in freely moving animals. Recordings contained multiple distinct voltage waveform shapes that were typically between 1 to 6 mV and lasted between 0.1 and 1 seconds. In the future, this implant will facilitate the identification of biomarkers in spinal cord injury and recovery, while enabling the delivery of localized treatments.

scholarly journals Characterization of neuronal discharge in the thoracic spinal cord during cardiac stress in a porcine model

2018 ◽  
Vol 32 (S1) ◽  
Author(s):  
Erica A. Dale ◽  
Jasmine P. Kipke ◽  
Michael D. Sunshine ◽  
Yukiko Kubo ◽  
Peter A. Castro ◽  
...  
Keyword(s):  
Spinal Cord ◽  
Porcine Model ◽  
Thoracic Spinal Cord ◽  
Cardiac Stress ◽  
Thoracic Spinal

scholarly journals Correction to: Characterization of the gut microbiome in a porcine model of thoracic spinal cord injury

BMC Genomics ◽  
2021 ◽  
Vol 22 (1) ◽  
Author(s):  
Adam Doelman ◽  
Seth Tigchelaar ◽  
Brian McConeghy ◽  
Sunita Sinha ◽  
Martin S. Keung ◽  
...  
Keyword(s):  
Spinal Cord ◽  
Spinal Cord Injury ◽  
Gut Microbiome ◽  
Porcine Model ◽  
Thoracic Spinal Cord ◽  
Thoracic Spinal ◽  
Cord Injury

Using Forelimb EMG to Control an Electronic Spinal Bridge to Facilitate Hindlimb Stepping After Complete Spinal Cord Lesion

2011 ◽  
Author(s):  
Parag Gad ◽  
Jonathan Woodbridge ◽  
Igor Lavrov ◽  
Yury Gerasimenko ◽  
Hui Zhong ◽  
...  
Keyword(s):  
Spinal Cord ◽  
Biceps Brachii ◽  
Detection Algorithm ◽  
Spinal Cord Transection ◽  
Emg Activity ◽  
Thoracic Spinal Cord ◽  
Epidural Stimulation ◽  
Lumbosacral Spinal Cord ◽  
Thoracic Spinal ◽  
Cord Injury

A complete spinal cord transection results in loss of all supraspinal motor control below the level of the injury. The neural circuitry in the lumbosacral spinal cord, however, can generate locomotor patterns in the hindlimbs of rats and cats with the aid of epidural stimulation and administration of serotoninergic agonists. We hypothesized that there are patterns of EMG signals from the forelimbs during quadrupedal locomotion that uniquely represent a signal for the “intent” to step with the hindlimbs. These observations led us to determine whether “indirect” volitional control of stepping can be restored after a complete spinal cord injury. We developed an electronic bridge that can trigger specific patterns of EMG activity from the forelimbs to enable quadrupedal stepping after a complete spinal cord transection in rats. We found dominant frequencies of 180–220 Hz in the EMG of forelimb muscles during active periods, whereas the frequencies were between 0–10 Hz when the muscles were inactive. A moving window detection algorithm was implemented in a small microprocessor to detect bilateral activity in the biceps brachii that then was used to initiate and terminate epidural stimulation. This detection algorithm was successful in detecting stepping under different pharmacological conditions and at various treadmill speeds and in facilitating quadrupedal stepping after a complete mid-thoracic spinal cord transection.

Sign in / Sign up

Export Citation Format

Share Document