MP26-07 INTRAVESICAL ONABOTULINUMTOXIN-A INJECTIONS DECREASE BOTH NERVE GROWTH FACTOR AND BRAIN DERIVED NEUROTROPHIC FACTOR LEVELS IN BLADDER TISSUE AND URINE IN PATIENTS WITH IDIOPATHIC AND NEUROGENIC DETRUSOR OVERACTIVITY

2017 ◽  
Vol 197 (4S) ◽  
Author(s):  
Jai Seth ◽  
Javed Burki ◽  
Juliana Ochulor ◽  
Rizwan Hamid
Keyword(s):  
Nerve Growth Factor ◽  
Growth Factor ◽  
Detrusor Overactivity ◽  
Neurotrophic Factor ◽  
Brain Derived Neurotrophic Factor ◽  
Neurogenic Detrusor Overactivity ◽  
Bladder Tissue ◽  
Nerve Growth ◽  
Onabotulinumtoxin A

scholarly journals Watching Neurons Hand Off Molecules

2002 ◽  
Vol 10 (1) ◽  
pp. 3-34
Author(s):  
Stephen W. Carmichael
Keyword(s):  
Nerve Growth Factor ◽  
Growth Factor ◽  
Neurotrophic Factors ◽  
Neurotrophic Factor ◽  
Brain Derived Neurotrophic Factor ◽  
Target Cells ◽  
Nerve Growth ◽  
Hand Off ◽  
Presynaptic Neurons

Since the discovery of nerve growth factor, it has been thought that neurotrophic factors are released or secreted from target cells. However, more recently it has been suggested that a specific neurotrophic factor known as brain-derived neurotrophic factor (BDNF) may reach target cells directly from pre-synaptic axons. It has not been known how these molecules get from the neuron in which they are produced to the target cells. Keigo Kohara, Akihiko Kitamura, Mieko Morishima, and Tadaharu Tsumoto have demonstrated that BDNF is transported anterogradely from presynaptic neurons to target neurons.

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