scholarly journals A New Method to Determine the Optimal Willingness to Pay in Cost-Effectiveness Analysis

2019 ◽  
Vol 22 (7) ◽  
pp. 785-791 ◽  
Author(s):  
Charles E. Phelps
2020 ◽  
Vol 25 (03) ◽  
pp. 129-130

Phelps CE. A New Method to Determine the Optimal Willingness to Pay in Cost-Effectiveness Analysis. Value Health. 2019; 22 (7): 785–791 Die Studie liefert einen neuen Ansatz zur Bestimmung der optimalen „Willingness to Pay“(WTP) für HTA‘s (health technology assessment). Die Analyse definiert den Nutzen als eine Funktion des Einkommens. Die Kalibrierung wurde mithilfe der abgeschätzten relativen Risikoaversion (r*) durchgeführt, von der die optimale WTP anhand der Ergebnisse von Garber und Phelps‘ aus dem Jahre 1997 bestimmt werden kann.


2019 ◽  
Vol 15 (1) ◽  
pp. 121-124
Author(s):  
Nor Aniza Azmi ◽  
Hairil Rashmizal Abdul Razak ◽  
Sobhan Vinjamuri

The present investigation deals with the assessment of clinicians perceived views on the impact of PET-CT in esophageal cancer management from practicality, clinical efficacy and cost –effectiveness point of views. Review of publication and retrospective data to develop and carry out a decision making model-based economic evaluation to investigate the relative cost-effectiveness of PET/CT in esophageal cancer management staging compared with conventional pathway. Clinicians identified from patient medical records included in the survey. Retrospective analysis of patient data from 2001-2008 taken from esophageal cancer patient medical records and North West Cancer Intelligence Services (NWCIS) database. A decision tree was developed using TREEAGE software. The results of the cost-effectiveness analysis are presented in terms of the incremental cost-effectiveness ratios (ICERs). PET compared with conventional work-up results for ICER for the strategy estimated at £28,460 per QALY; PET/CT compared with PET for ICER was £ 32,590 per QALY; and the ICER for PET/CT combined with conventional work-up versus PET/CT was £ 44,118. The package become more expensive with each additional diagnostic test added to PET and more effective in terms of QALYs gained. The conventional work-up is the preferred options as probabilistic sensitivity analysis shows at a willingness-to-pay threshold of £ 20,000 per QALY. Result of the current analysis suggests that the use of PET/CT in the diagnosis of esophageal cancer is unlikely to be cost-effective given the current willingness-to-pay thresholds that are accepted in the United Kingdom by decision-making bodies such as the National Institute for Health and Clinical Excellence. 


2019 ◽  
Vol 22 (12) ◽  
pp. 1370-1377 ◽  
Author(s):  
Tomas Mlcoch ◽  
Tereza Hrnciarova ◽  
Jan Tuzil ◽  
Jakub Zadak ◽  
Marisca Marian ◽  
...  

2020 ◽  
pp. 112070002095277
Author(s):  
Philip J Rosinsky ◽  
Cammille C Go ◽  
Rishika Bheem ◽  
Jacob Shapira ◽  
David R Maldonado ◽  
...  

Purpose: The purpose of this study was to perform a cost-effectiveness analysis of outpatient versus inpatient total hip arthroplasty (THA) in the USA, considering complication probability and the potential cost of such complications. Methods: A cost-effectiveness analysis was conducted from the societal perspective to evaluate the incremental cost and effectiveness of inpatient THA compared to outpatient THA over a lifetime horizon. Effectiveness was expressed in quality-adjusted life years (QALYs). Costs, expressed in 2019 US dollars, transition probabilities, and health utilities were derived from the literature. The primary outcome was the incremental cost-effectiveness ratio (ICER), with a willingness to pay (WTP) threshold set at $50,000/QALY. 1-way and probabilistic sensitivity analyses was performed to evaluate the effect of the various variables on the model. Results: In the base case, inpatient THA was more effective in terms of total utility (10.36 vs. 10.30 QALY), but also more costly ($48,155 ± 1673 vs. $43,288 ± 1, 606 for Medicare) than outpatient THA. Even with a lifetime horizon, the ICER was $81,116 per QALY and $140,917 per QALY for Medicare and private payer insurance, respectively, which is higher than the willingness to pay threshold. 1-way sensitivity analyses indicated that the variables having the most influence on the model were the utility of inpatient and outpatient THA and cost of inpatient and outpatient THA. Conclusions: This model determined that for a WTP threshold set at $50,000/QALY, outpatient THA is more cost-effective than inpatient THA from a societal perspective. Despite this, surgeons must weigh clinical factors first and foremost in determining if an individual patient can be safely operated on in the outpatient setting.


2020 ◽  
Author(s):  
Lihui Zhou ◽  
Ye Cao ◽  
Bei Gao ◽  
Wenli Lu ◽  
Yuan Wang

Abstract Objectives: To evaluate the cost-effectiveness of community-based Atrial fibrillation (AF) screening by 12-lead electrocardiogram (ECG) in Chinese healthcare setting.Methods: A Markov state transition model was used to simulate the costs and effects on a 55/65/75-year-old cohort under routine care and AF screening by 12-lead ECG. The circle length was 1 year, and people were simulated until 90 years old. The cost-effectiveness analysis was perform using a societal perspective. Transition probability, costs, and utility data were derived from open dataset and published literature. One-way and probabilistic sensitivity analyses were performed to exam the uncertainty of the results. Results: Annual AF screening in 65/75-year-old cohort was highly cost-effective with the incremental cost-effectiveness ratio (ICER) Chinese Yuan Renminbi (CNY) 64147/49736 per quality-adjusted life year (QALY) gained. Annual AF screening in 65/75-year-old cohort was associated with 535/492 prevented ischemic strokes and 174/163 more intracerebral hemorrhages, and the anticoagulation rate increased from the assumed 10% on routine care to 61.5%. Probabilistic sensitivity analysis indicated that these two strategies have 55% and 78% chances of being cost-effective at a willingness-to-pay (WTP) threshold of 1× gross domestic product per capita of China in 2019, US $10635 QALY.Conclusion: Annual community-based screening of population aged 65 years and older in China is likely to be cost-effective at conventional willingness-to-pay thresholds to reduce the unnecessary burden of strokes.


2002 ◽  
Author(s):  
Eugene Laska ◽  
Morris Meisner ◽  
Carole Siegel ◽  
Joseph Wanderling

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