PSS1 Efficacy and Safety of Ibuprofen PLUS Paracetamol in a Fixed-Dose Combination for ACUTE Postoperative PAIN in Adults: Meta-Analysis and a Trial Sequential Analysis

2021 ◽  
Vol 24 ◽  
pp. S220
Author(s):  
D. Abushanab ◽  
D. Al-Badriyeh
Keyword(s):  
Postoperative Pain ◽  
Sequential Analysis ◽  
Meta Analysis ◽  
Fixed Dose Combination ◽  
Fixed Dose ◽  
Trial Sequential Analysis ◽  
Efficacy And Safety ◽  
Acute Postoperative Pain ◽  
Dose Combination

Efficacy and safety of aclidinium/formoterol fixed-dose combination in patients with COPD, stratified by ICS use

Pneumologie ◽  
2016 ◽  
Vol 70 (S 01) ◽  
Author(s):  
ED Bateman ◽  
K Chapman ◽  
S Rennard ◽  
L Rekeda ◽  
M Moya ◽  
...  
Keyword(s):  
Fixed Dose Combination ◽  
Fixed Dose ◽  
Efficacy And Safety ◽  
Dose Combination

scholarly journals POST-MARKETING SURVEILLANCE STUDY TO SUBSTANTIATE THE EFFICACY AND SAFETY FOR THE COMBINATION OF PARACETAMOL, PHENYLEPHRINE AND CHLORPHENIRAMINE MALEATE IN INDIAN PATIENTS OF COMMON COLD

2021 ◽  
Vol 5 (7) ◽  
Author(s):  
Mayuresh Kiran ◽  
Lalit Pawaskar ◽  
Shaheen Sheikh ◽  
Pramita Waghambare
Keyword(s):  
Common Cold ◽  
Symptomatic Treatment ◽  
Fixed Dose Combination ◽  
Fixed Dose ◽  
Efficacy And Safety ◽  
Chlorpheniramine Maleate ◽  
Phenylephrine Hydrochloride ◽  
Indian Patients ◽  
Post Marketing Surveillance ◽  
Dose Combination

Introduction: Common cold is frequently occurring medical condition in developing countries like India. Common cold is self-limiting in nature so symptomatic treatment is always suggested. This study was conducted to test the efficacy and safety for the fixed dose combination of Paracetamol 500 mg, Phenylephrine Hydrochloride 10 mg and Chlorpheniramine Maleate 2 mg per tablet for the treatment of common cold. Methodology: Total 180 patients were enrolled out of which 159 completed the study. Efficacy assessment was done by decrease in total symptom score (TSS) of common cold at day 3 and 5 as compared to the baseline (day 1). Safety assessment was made by analyzing the reported adverse events through the study. Results: Mean TSS at baseline was 6.62 which was decreased to 3.55 at day 3 and was further decreased to 0.68 at day 5. Majority of patients had complete relief from the symptoms of common cold and nearly all the patients had >50 % reduction in TSS. Also no unexpected or serious adverse event was found to be reported in the study duration of 5 days. Conclusion:  Fixed dose combination of Paracetamol 500 mg, Phenylephrine Hydrochloride 10 mg and Chlorpheniramine Maleate 2 mg per tablet was found to be efficacious and safe for the symptomatic treatment of common cold in Indian patients. Keywords: Common cold, Paracetamol, Chlorpheniramine Maleate and Phenylephrine

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