The role of time-resolved MRA for assessment of post-treated pulmonary arteriovenous malformations: a pictorial review

2015 ◽  
Vol 26 (2) ◽  
pp. S154-S155
Author(s):  
T. Kawai ◽  
M. Shimohira ◽  
K. Ohta ◽  
T. Hashizume ◽  
M. Muto ◽  
...  
Keyword(s):  
Arteriovenous Malformations ◽  
Pulmonary Arteriovenous Malformations ◽  
Time Resolved ◽  
Pictorial Review

The role of angiogenesis in the development of pulmonary arteriovenous malformations in children after cavopulmonary anastomosis

1997 ◽  
Vol 7 (4) ◽  
pp. 370-374 ◽  
Author(s):  
Blair Marshall ◽  
Brian W. Duncan ◽  
Richard A. Jonas
Keyword(s):  
Arteriovenous Malformations ◽  
Fontan Procedure ◽  
Pulmonary Arteriovenous Malformations ◽  
Arterial Circulation ◽  
Clinical Observations ◽  
Bidirectional Glenn Shunt ◽  
Cavopulmonary Anastomosis ◽  
Pulmonary Arterial ◽  
End Stage

AbstractPulmonary arteriovenous malformations are a frequent cause of progressive cyanosis after construction of a cavopulmonary anastomosis. Their formation complicates the management of children with single ventricle physiology after a bidirectional Glenn shunt or the Kawashima procedure. The key role of the liver in this phenomenon is suggested by the observation that providing modifications of the Fontan procedure which permit hepatic venous effluent to reach the pulmonary arterial circulation limit further development of the malformations. In addition, it is known that patients with end-stage hepatic failure develop pulmonary arteriovenous malformations that diminish after liver transplantation. We have begun purification of a factor derived from hepatocyte-conditioned media that is inhibitory for the proliferation of cultured endothelial cells. This substance is heat sensitive, and binds avidly to a copper-containing chromatography column. These clinical observations, and this preliminary experimental work, support the concept that hepatic-derived angiogenic factors may play a role in the development of pulmonary arteriovenous malformations after construction of cavopulmonary anastomoses.

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