DNA repair gene XPD polymorphism and lung cancer risk: a meta-analysis

Lung Cancer ◽  
2004 ◽  
Vol 46 (1) ◽  
pp. 1-10 ◽  
Author(s):  
Z. Hu ◽  
Q. Wei ◽  
X. Wang ◽  
H. Shen
Keyword(s):  
Lung Cancer ◽  
Dna Repair ◽  
Cancer Risk ◽  
Lung Cancer Risk ◽  
Meta Analysis ◽  
Repair Gene ◽  
Dna Repair Gene

DNA repair gene XRCC3 Thr241Met polymorphisms and lung cancer risk: A meta-analysis

2015 ◽  
Vol 102 (4) ◽  
pp. 332-339 ◽  
Author(s):  
Liu Bei ◽  
Tan Xiao-dong ◽  
Gao Yu-fang ◽  
Sun Jian-ping ◽  
Ying Zhao-yu
Keyword(s):  
Lung Cancer ◽  
Dna Repair ◽  
Cancer Risk ◽  
Lung Cancer Risk ◽  
Meta Analysis ◽  
Repair Gene ◽  
Dna Repair Gene ◽  
Xrcc3 Thr241met

Comprehensive assessment of the association between DNA repair gene XRCC3 rs861539 C/T polymorphism and lung cancer risk

Tumor Biology ◽  
2013 ◽  
Vol 34 (5) ◽  
pp. 2521-2527 ◽  
Author(s):  
Gang Ding ◽  
Weiguo Xu ◽  
Hongwei Hua ◽  
Qian Huang ◽  
Hongxiang Liang ◽  
...  
Keyword(s):  
Lung Cancer ◽  
Dna Repair ◽  
Cancer Risk ◽  
Lung Cancer Risk ◽  
Comprehensive Assessment ◽  
Repair Gene ◽  
Dna Repair Gene

Abstract 4597: A novel variant in DNA repair gene GTF2H4 is associated with lung cancer risk: A reanalysis of GWAS datasets from the TRICL consortium

2015 ◽  
Author(s):  
Qingyi Wei ◽  
Hongliang Liu ◽  
Zhensheng Liu ◽  
Christopher I. Amos ◽  
Jennifer A. Doherty ◽  
...  
Keyword(s):  
Lung Cancer ◽  
Dna Repair ◽  
Cancer Risk ◽  
Lung Cancer Risk ◽  
Repair Gene ◽  
Dna Repair Gene ◽  
Novel Variant

scholarly journals Lung Cancer Risk and Genetic Polymorphisms in DNA Repair Pathways: A Meta-Analysis

2010 ◽  
Vol 2010 ◽  
pp. 1-17 ◽  
Author(s):  
Chikako Kiyohara ◽  
Koichi Takayama ◽  
Yoichi Nakanishi
Keyword(s):  
Lung Cancer ◽  
Dna Repair ◽  
Cancer Risk ◽  
Genetic Polymorphisms ◽  
Lung Cancer Risk ◽  
Excision Repair ◽  
Meta Analysis ◽  
Epidemiologic Studies ◽  
Repair Capacity ◽  
Repair Pathways

Genetic variations in DNA repair genes are thought to modulate DNA repair capacity and are suggested to be related to lung cancer risk. We conducted a meta-analysis of epidemiologic studies on the association between genetic polymorphisms in both base excision repair and nucleotide excision repair pathways, and lung cancer. We found xeroderma pigmentosum complementation group A (XPA) G23A (odds ratio (OR)=0.76, 95% confidence interval (CI)=0.61–0.94), 8-oxoguanine DNA glycosylase 1 (OGG1) Ser326Cys (OR=1.22, 95% CI=1.02–1.45), and excision repair cross-complementing group 2 (ERCC2) Lys751Gln (OR=1.27, 95% CI=1.10–1.46) polymorphisms were associated with lung cancer risk. Considering the data available, it can be conjectured that if there is any risk association between a single SNP and lung cancer, the risk fluctuation will probably be minimal. Advances in the identification of new polymorphisms and in high-throughput genotyping techniques will facilitate the analysis of multiple genes in multiple DNA repair pathways. Therefore, it is likely that the defining feature of future epidemiologic studies will be the simultaneous analysis of large samples of cases and controls.

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