The properties of nanoparticles can be exploited to overcome challenges in drug delivery. By virtue of
its design and size, the pharmacokinetics of nanoparticles are different than other small molecules. Modeling and
simulation techniques have great potential to be used in nanoformulation development; however, their use in
optimization of nanoformulation is very limited. This review highlights the differences in absorption, distribution,
metabolism and excretion (ADME) characteristics of nanoparticles, use of modeling and simulation techniques in
nanoformulation development and challenges in the implementation of modeling techniques.
