Differential role of lipoteichoic acids isolated from Staphylococcus aureus and Lactobacillus plantarum on the aggravation and alleviation of atopic dermatitis

Atopic dermatitis (AD) is a chronic and inflammatory skin disease with intense pruritus and xerosis. AD pathogenesis is multifactorial, involving genetic, environmental, and immunological factors, including the participation of Staphylococcus aureus. This bacterium colonizes up to 30–100% of AD skin and its virulence factors are responsible for its pathogenicity and antimicrobial survival. This is a concise review of S. aureus superantigen-activated signaling pathways, highlighting their involvement in AD pathogenesis, with an emphasis on skin barrier disruption, innate and adaptive immunity dysfunction, and microbiome alterations. A better understanding of the combined mechanisms of AD pathogenesis may enhance the development of future targeted therapies for this complex disease.

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Role of Staphylococcus aureus Nasal Colonization in Atopic Dermatitis in Infants

Archives of Pediatrics and Adolescent Medicine ◽

10.1001/archpediatrics.2009.117 ◽

2009 ◽

Vol 163 (8) ◽

Cited By ~ 36

Author(s):

Ankie Lebon ◽

Joost A. M. Labout ◽

Henri A. Verbrugh ◽

Vincent W. V. Jaddoe ◽

Albert Hofman ◽

...

Keyword(s):

Staphylococcus Aureus ◽

Atopic Dermatitis ◽

Nasal Colonization

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What is the role of Staphylococcus aureus and herpes virus infections in the pathogenesis of atopic dermatitis?

Future Microbiology ◽

10.2217/fmb-2017-0081 ◽

2017 ◽

Vol 12 (14) ◽

pp. 1327-1334 ◽

Cited By ~ 3

Author(s):

Simone Saintive ◽

Eliane Abad ◽

Dennis de C Ferreira ◽

Mayra Stambovsky ◽

Fernanda S Cavalcante ◽

...

Keyword(s):

Staphylococcus Aureus ◽

Atopic Dermatitis ◽

Herpes Virus ◽

Virus Infections ◽

Herpes Virus Infections ◽

Herpès Virus

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Incorrect Data in: Role of Staphylococcus aureus Nasal Colonization in Atopic Dermatitis in Infants: The Generation R Study

Archives of Pediatrics and Adolescent Medicine ◽

10.1001/archpediatrics.2010.27 ◽

2010 ◽

Vol 164 (4) ◽

pp. 334 ◽

Cited By ~ 2

Keyword(s):

Staphylococcus Aureus ◽

Atopic Dermatitis ◽

Nasal Colonization ◽

Incorrect Data

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Colonization With Staphylococcus aureus in Atopic Dermatitis Patients: Attempts to Reveal the Unknown

Frontiers in Microbiology ◽

10.3389/fmicb.2020.567090 ◽

2021 ◽

Vol 11 ◽

Author(s):

Patrycja Ogonowska ◽

Yolanda Gilaberte ◽

Wioletta Barańska-Rybak ◽

Joanna Nakonieczna

Keyword(s):

Staphylococcus Aureus ◽

Atopic Dermatitis ◽

Virulence Factors ◽

Special Interest ◽

Genetic Background ◽

Skin Infection ◽

Healthy Population ◽

Drug Resistant ◽

Lesional Skin

Atopic dermatitis (AD) patients are massively colonized with Staphylococcus aureus (S. aureus) in lesional and non-lesional skin. A skin infection may become systemic if left untreated. Of interest, the incidence of multi-drug resistant S. aureus (MRSA) in AD patients is higher as compared to a healthy population, which makes treatment even more challenging. Information on the specific genetic background of S. aureus accompanying and/or causing AD flares would be of great importance in terms of possible treatment option development. In this review, we summarized the data on the prevalence of S. aureus in general in AD skin, and the prevalence of specific clones that might be associated with flares of eczema. We put our special interest in the presence and role of staphylococcal enterotoxins as important virulence factors in the epidemiology of AD-derived S. aureus. Also, we summarize the present and potentially useful future anti-staphylococcal treatment.

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