Role of Staphylococcus aureus Nasal Colonization in Atopic Dermatitis in Infants

Background: Atopic dermatitis (AD) is a chronic inflammatory skin disease with multifactorial etiologies, Staphylococcus aureus (S.aureus) and methicillinresistant S.aureus (MRSA) that naturally colonize skin and nose are prevalent among children with AD. Objectives: was to determine the prevalence of S.aureus and MRSA colonization of skin lesions and nose of AD children. Methodology: 40 children diagnosed as AD from Dermatology Clinic of Najran Armed Forces Hospital, Saudi Arabia, were included in the study; separate swabs from skin lesions & nose of each AD patient were tested for S.aureus and MRSA colonization using the conventional culture based Vitek 2 system and the molecular BD Max MRSA XT assay. Results: Using the conventional Vitek 2 system, the prevalence of skin and nasal colonization with S.aureus in AD patients were 25% and 30% respectively while skin and nasal colonization with MRSA were 7.5% and 7.5% respectively, the BD Max MRSA XT assay identified correctly S.aureus with overall 96 % sensitivity, 100 % specificity and 98 % diagnostic accuracy and identified 100 % of MRSA strains. Conclusion: The increase in prevalence of skin and nasal colonization with S.aureus and MRSA among AD children raises the concern about importance of the accurate and rapid molecular diagnostic techniques for preventing the potential risk of MRSA transmission

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Colonization with Staphylococcus aureus in patients with hand eczema: Prevalence and association with severity, atopic dermatitis, subtype and nasal colonization

Contact Dermatitis ◽

10.1111/cod.13679 ◽

2020 ◽

Vol 83 (6) ◽

pp. 442-449

Author(s):

Line B. Nørreslet ◽

Sofie M. Edslev ◽

Paal S. Andersen ◽

Frederik Plum ◽

Jette Holt ◽

...

Keyword(s):

Staphylococcus Aureus ◽

Atopic Dermatitis ◽

Hand Eczema ◽

Nasal Colonization

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Role of Staphylococcus aureus in Atopic Dermatitis

Atopic Dermatitis, Second Edition ◽

10.3109/9781420077995-16 ◽

2009 ◽

pp. 309-319 ◽

Cited By ~ 1

Author(s):

Peck Ong

Keyword(s):

Staphylococcus Aureus ◽

Atopic Dermatitis

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Exploring the Role of Staphylococcus Aureus Toxins in Atopic Dermatitis

Toxins ◽

10.3390/toxins11060321 ◽

2019 ◽

Vol 11 (6) ◽

pp. 321 ◽

Cited By ~ 5

Author(s):

Fabio Seiti Yamada Yoshikawa ◽

Josenilson Feitosa de Lima ◽

Maria Notomi Sato ◽

Yasmin Álefe Leuzzi Ramos ◽

Valeria Aoki ◽

...

Keyword(s):

Staphylococcus Aureus ◽

Atopic Dermatitis ◽

Complex Disease ◽

Skin Barrier ◽

Inflammatory Skin Disease ◽

Innate And Adaptive Immunity ◽

Concise Review ◽

Intense Pruritus ◽

Immunological Factors

Atopic dermatitis (AD) is a chronic and inflammatory skin disease with intense pruritus and xerosis. AD pathogenesis is multifactorial, involving genetic, environmental, and immunological factors, including the participation of Staphylococcus aureus. This bacterium colonizes up to 30–100% of AD skin and its virulence factors are responsible for its pathogenicity and antimicrobial survival. This is a concise review of S. aureus superantigen-activated signaling pathways, highlighting their involvement in AD pathogenesis, with an emphasis on skin barrier disruption, innate and adaptive immunity dysfunction, and microbiome alterations. A better understanding of the combined mechanisms of AD pathogenesis may enhance the development of future targeted therapies for this complex disease.

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