scholarly journals Bovine leukemia virus relation to human breast cancer: Meta-analysis

2020 ◽  
Vol 149 ◽  
pp. 104417
Author(s):  
Andrew Gao ◽  
Valentina L. Kouznetsova ◽  
Igor F. Tsigelny
Keyword(s):  
Breast Cancer ◽  
Bovine Leukemia Virus ◽  
Human Breast Cancer ◽  
Meta Analysis ◽  
Leukemia Virus ◽  
Human Breast

scholarly journals Can Bovine Leukemia Virus Be Related to Human Breast Cancer? A Review of the Evidence

2018 ◽  
Vol 23 (3) ◽  
pp. 101-107 ◽  
Author(s):  
Lucia Martinez Cuesta ◽  
Pamela Anahi Lendez ◽  
Maria Victoria Nieto Farias ◽  
Guillermina Laura Dolcini ◽  
Maria Carolina Ceriani
Keyword(s):  
Breast Cancer ◽  
Bovine Leukemia Virus ◽  
Human Breast Cancer ◽  
Leukemia Virus ◽  
Human Breast

scholarly journals High positivity values for bovine leukemia virus in human breast cancer cases from Minas Gerais, Brazil

PLoS ONE ◽  
2020 ◽  
Vol 15 (10) ◽  
pp. e0239745
Author(s):  
Emília Delarmelina ◽  
Marcelo Araújo Buzelin ◽  
Breno Samuel de Souza ◽  
Francielli Martins Souto ◽  
Juliana Marques Bicalho ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Bovine Leukemia Virus ◽  
Human Breast Cancer ◽  
Leukemia Virus ◽  
Minas Gerais ◽  
Human Breast

scholarly journals Prognosis of PD-L1 in human breast cancer: protocol for a systematic review and meta-analysis

2020 ◽  
Vol 9 (1) ◽  
Author(s):  
Isnard Elman Litvin ◽  
Machline Paim Paganella ◽  
Eliana Marcia Wendland ◽  
Adriana Vial Roehe
Keyword(s):  
Breast Cancer ◽  
Systematic Review ◽  
Human Breast Cancer ◽  
Meta Analysis ◽  
Human Breast

scholarly journals Poly(ADP-ribose) polymerase-1 mRNA expression in human breast cancer: a meta-analysis

2010 ◽  
Vol 127 (1) ◽  
pp. 273-281 ◽  
Author(s):  
Anthony Gonçalves ◽  
Pascal Finetti ◽  
Renaud Sabatier ◽  
Marine Gilabert ◽  
José Adelaide ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Mrna Expression ◽  
Human Breast Cancer ◽  
Meta Analysis ◽  
Human Breast

scholarly journals Bovine Leukemia virus (BLV) and risk of breast cancer: a systematic review and meta-analysis of case-control studies

2020 ◽  
Vol 15 (1) ◽  
Author(s):  
Alireza Khatami ◽  
Ali Pormohammad ◽  
Rana Farzi ◽  
Hassan Saadati ◽  
Maryam Mehrabi ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Systematic Review ◽  
Bovine Leukemia Virus ◽  
Meta Analysis ◽  
Leukemia Virus ◽  
Case Control ◽  
Case Control Studies

scholarly journals Does mouse mammary tumor-like virus cause human breast cancer? Applying Bradford Hill criteria postulates

2020 ◽  
Vol 44 (1) ◽  
Author(s):  
Yasir Hameed ◽  
Muhammad Usman ◽  
Mukhtiar Ahmad
Keyword(s):  
Breast Cancer ◽  
Causal Relationship ◽  
Mammary Tumor ◽  
Human Breast Cancer ◽  
Meta Analysis ◽  
Human Breast ◽  
Mouse Mammary Tumor ◽  
Bradford Hill ◽  
Bradford Hill Criteria ◽  
Hill Criteria

Abstract Background The role of mouse mammary tumor-like virus (MMTV-like virus) in human breast cancer (BC) has already been widely investigated worldwide with conflicting results. Although the researchers tried to establish the link between MMTV-like virus and BC through the statistical meta-analysis of the previous studies associating MMTV-like virus with BC, they failed to establish a more reliable link due to the shortcomings of the statistical meta-analysis. In the present study, we identified population-wide studies relating MMTV-like virus with BC through the PubMed search engine. Then, we examined the available data of MMTV-like virus prevalence in BC, normal/benign samples, and applied the postulates of Bradford Hill criteria on the available evidence to investigate the association between MMTV-like virus and BC. In addition, to further enhance the reliability of our outcomes, we have also evaluated the methodologies of the previous studies to address the possibility of false-negative and false-positive results. Results After a careful evaluation of the extracted data against the postulates of Bradford Hill criteria, it was observed that none of the studies fulfill all the major postulates of Bradford Hill criteria for causation including temporality, consistency, biological gradient, experiment, coherence, specificity, and analogy. Hence, no causal relationship has been suggested between MMTV-like virus and BC patients of the any included population. Conclusion The results failed to prove the causal relationship between MMTV-like virus and BC rather suggested it as a co-participant in the pathogenesis of BC.

scholarly journals Catching viral breast cancer

2021 ◽  
Vol 16 (1) ◽  
Author(s):  
James S. Lawson ◽  
Wendy K. Glenn
Keyword(s):  
Breast Cancer ◽  
Human Breast Cancer ◽  
Breast Tissue ◽  
Leukemia Virus ◽  
Breast Cancers ◽  
Human Breast ◽  
Mouse Mammary Tumour Virus ◽  
Barr Virus ◽  
Benign Breast Tissue ◽  
Epstein Barr

Abstract We have considered viruses and their contribution to breast cancer. Mouse mammary tumour virus The prevalence of mouse mammary tumour virus (MMTV) is 15-fold higher in human breast cancer than in normal and benign human breast tissue controls. Saliva is the most plausible means of transmission. MMTV has been identified in dogs, cats, monkeys, mice and rats. The causal mechanisms include insertional oncogenesis and mutations in the protective enzyme ABOBEC3B. Human papilloma virus The prevalence of high risk human papilloma viruses (HPV) is frequently six fold higher in breast cancer than in normal and benign breast tissue controls. Women who develop HPV associated cervical cancer are at higher than normal risk of developing HPV associated breast cancer. Koilocytes have been identified in breast cancers which is an indication of HPV oncogenicity. The causal mechanisms of HPVs in breast cancer appear to differ from cervical cancer. Sexual activity is the most common form of HPV transmission. HPVs are probably transmitted from the cervix to the breast by circulating extra cellular vesicles. Epstein Barr virus The prevalence of Epstein Barr virus (EBV) is five fold higher in breast cancer than in normal and benign breast tissue controls. EBV is mostly transmitted from person to person via saliva. EBV infection predisposes breast epithelial cells to malignant transformation through activation of HER2/HER3 signalling cascades. EBV EBNA genes contribute to tumour growth and metastasis and have the ability to affect the mesenchymal transition of cells. Bovine leukemia virus Bovine leukemia virus (BLV) infects beef and dairy cattle and leads to various cancers. The prevalence of BLV is double in human breast cancers compared to controls. Breast cancer is more prevalent in red meat eating and cow’s milk consuming populations. BLV may be transmitted to humans from cattle by the consumption of red meat and cow’s milk. Conclusion The evidence that MMTV, high risk HPVs and EBVs have causal roles in human breast cancer is compelling. The evidence with respect to BLV is more limited but it is likely to also have a causal role in human breast cancer.

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