scholarly journals Bovine Leukemia virus (BLV) and risk of breast cancer: a systematic review and meta-analysis of case-control studies

2020 ◽  
Vol 15 (1) ◽  
Author(s):  
Alireza Khatami ◽  
Ali Pormohammad ◽  
Rana Farzi ◽  
Hassan Saadati ◽  
Maryam Mehrabi ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Systematic Review ◽  
Bovine Leukemia Virus ◽  
Meta Analysis ◽  
Leukemia Virus ◽  
Case Control ◽  
Case Control Studies

scholarly journals The association between ATM variants and risk of breast cancer: a systematic review and meta-analysis

BMC Cancer ◽  
2021 ◽  
Vol 21 (1) ◽  
Author(s):  
Masoumeh Moslemi ◽  
Yousef Moradi ◽  
Hojat Dehghanbanadaki ◽  
Hamed Afkhami ◽  
Mansoor Khaledi ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Systematic Review ◽  
Meta Analysis ◽  
Predictive Ability ◽  
Case Control ◽  
Ataxia Telangiectasia Mutated ◽  
Case Control Studies ◽  
Predisposing Factor ◽  
Increased Risk ◽  
Atm Gene

Abstract Background Ataxia telangiectasia-mutated (ATM) gene contributes to repair damaged DNA and to regulate cell cycle; therefore, ATM variants seem to increase breast cancer risk; however, the results are controversial. So we conducted a systematic review and meta-analysis to clarify the pooled association between various ATM variants and the risk of breast cancer. Methods The relevant studies were searched through Scopus, Web of Science, PubMed and Cochrane. Stratified and subgroup analyses were performed to explore heterogeneity between studies and assess effects of study quality. The pooled estimates logarithm with standard error logarithm of odds ratio and relative risk with confidence interval were calculated. Results This study revealed that there is association between ATM variants and the risk of breast cancer; according to the seven adjusted case-control studies, OR of this association was estimated as 1.67 (95%CI: 0.73–3.82), according to nine unadjusted case-control studies, the crude OR was 2.27 (95% CI: 1.17–4.40) and according to two cohorts, the RR was estimated as 1.68 (95% CI: 1.17–2.40). Conclusions The ATM variants are associated with an increased risk of breast cancer that ATM V2424G mutation is detected as the most predisposing factor while ATM D1853V, L546V, and S707P variants have the least predictive ability.

scholarly journals Evaluation of association studies and a systematic review and meta-analysis of CYP1A1 T3801C and A2455G polymorphisms in breast cancer risk

PLoS ONE ◽  
2021 ◽  
Vol 16 (4) ◽  
pp. e0249632
Author(s):  
Chen Yang ◽  
Xiao-Feng He
Keyword(s):  
Breast Cancer ◽  
Systematic Review ◽  
Sensitivity Analysis ◽  
Breast Cancer Risk ◽  
Association Studies ◽  
Meta Analysis ◽  
Case Control ◽  
Case Control Studies ◽  
Meta Analyses ◽  
Positive Results

Background Nine previous meta-analyses have been published to analyze the CYP1A1 T3801C and A2455G polymorphisms with BC risk. However, they did not assess the credibility of statistically significant associations. In addition, many new studies have been reported on the above themes. Hence, we conducted an updated systematic review and meta-analysis to further explore the above issues. Objectives To explore the association on the CYP1A1 T3801C and A2455G polymorphisms with BC risk. Methods Preferred Reporting Items for Systematic Reviews and Meta-Analyses (The PRISMA) were used. Results In this study, there were 63 case–control studies from 56 publications on the CYP1A1 T3801C polymorphism (including 20,825 BC cases and 25,495 controls) and 51 case–control studies from 46 publications on the CYP1A1 A2455G polymorphism (including 20,124 BC cases and 29,183 controls). Overall, the CYP1A1 T3801C polymorphism was significantly increased BC risk in overall analysis, especially in Asians and Indians; the CYP1A1 A2455G polymorphism was associated with BC risk in overall analysis, Indians, and postmenopausal women. However, when we used BFDP correction, associations remained significant only in Indians (CC vs. TT + TC: BFDP < 0.001) for the CYP1A1 T3801C polymorphism with BC risk, but not in the CYP1A1 A2455G polymorphism. In addition, when we further performed sensitivity analysis, no significant association in overall analysis and any subgroup. Moreover, we found that all studies from Indians was low quality. Therefore, the results may be not credible. Conclusion This meta-analysis strongly indicates that there is no significant association between the CYP1A1 T3801C and A2455G polymorphisms and BC risk. The increased BC risk may most likely on account of false-positive results.

scholarly journals Mushroom Consumption Is Associated with Low Risk of Cancer: A Systematic Review and Meta-Analysis of Observation Studies

2020 ◽  
Vol 4 (Supplement_2) ◽  
pp. 307-307 ◽  
Author(s):  
Djibril Ba ◽  
Paddy Ssentongo ◽  
Robert Beelman ◽  
Xiang Gao ◽  
John Richie
Keyword(s):  
Breast Cancer ◽  
Systematic Review ◽  
Confidence Intervals ◽  
Dose Response ◽  
Lower Risk ◽  
Meta Analysis ◽  
Case Control ◽  
Low Risk ◽  
Case Control Studies ◽  
Risk Of Cancer

Abstract Objectives The potential health benefits associated with mushroom consumption, including reductions in risk of cancer have gained recent research attention. We thus conducted a systematic review and meta-analysis to assess the association between mushrooms intake and risk of cancer at any site. Methods We searched MEDLINE, Web of Science, and Cochrane Library to identify relevant studies on mushrooms intake and cancer published from January 1, 1966 to October 1, 2019.  Observational studies with relative risks (RRs) or hazard ratios (HRs) or odds ratios (ORs) and 95% confidence intervals (CIs) of cancer risk for two or more categories of mushroom intake were eligible for the present studies.  Random-effects models were used to pool study results and to assess dose-response relationships between mushroom consumption and the risk of cancer. Results There were 17 studies (6 cohort and 11 case-control studies) for a total of 20,797 cancer cases. Mushroom consumption was associated with lower risk of cancer – the pooled RR was 0.66 (95% Confidence Intervals (CI): 0.55–0.78) for the highest vs lowest mushroom intakes groups. There was substantial heterogeneity between studies (I2 = 77%; p for heterogeneity &lt; 0.01). Mushroom consumption was associated with lower risk of cancer in cohort studies (RR = 0.90, 95% CI: 0.82–0.99; n = 6)  and case-control studies (RR = 0.52, 95% CI: 0.41–0.66; n = 11). Subgroup analysis showed that the significant mushroom cancer association was only observed in studies from non-western regions (RR = 0.58, 95% CI: 0.47–0.71, p = 0.02; n = 14). Mushroom  consumption was associated with low risk of  breast cancer (RR = 0.65, 95% CI: 0.52–0.81) compared to non-breast cancer. Dose-response analysis suggested that 10 g/day increase in mushroom intakes was associated with a 17% lower risk of cancer (RR = 0.83, 95% CI: 0.73–0.96, P-trend = 0.01). Conclusions The current meta-analysis showed a significant inverse association between greater mushroom consumption and low risk of cancer. In particular, breast cancer appeared to be the most affected site as significant association with mushroom intake were only observed for cancers at this site. Large prospective studies, ideally randomized  controlled trials, are needed to investigate the association between mushrooms intake and risk of cancer. Funding Sources There was no external or internal funding to support this study.

Association of ACE I/D, -240A > T and AT1R A1166C polymorphisms with susceptibility to breast cancer: a systematic review and meta-analysis based on 35 case-control studies

2020 ◽  
Vol 40 (1) ◽  
pp. 117-135
Author(s):  
Seyed Alireza Dastgheib ◽  
Fatemeh Asadian ◽  
Meraj Farbod ◽  
Mojgan Karimi-Zarchi ◽  
Bahare Meibodi ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Systematic Review ◽  
Meta Analysis ◽  
Case Control ◽  
Case Control Studies

scholarly journals Light at night and risk of breast cancer: a systematic review and dose–response meta-analysis

2021 ◽  
Vol 20 (1) ◽  
Author(s):  
Teresa Urbano ◽  
Marco Vinceti ◽  
Lauren A. Wise ◽  
Tommaso Filippini
Keyword(s):  
Breast Cancer ◽  
Systematic Review ◽  
Breast Cancer Risk ◽  
Dose Response ◽  
Meta Analysis ◽  
Premenopausal Women ◽  
Positive Association ◽  
Case Control ◽  
Case Control Studies ◽  
Light At Night

AbstractBreast cancer is the most common malignancy in women and the second leading cause of cancer death overall. Besides genetic, reproductive, and hormonal factors involved in disease onset and progression, greater attention has focused recently on the etiologic role of environmental factors, including exposure to artificial lighting such as light-at-night (LAN). We investigated the extent to which LAN, including outdoor and indoor exposure, affects breast cancer risk. We performed a systematic review of epidemiological evidence on the association between LAN exposure and breast cancer risk, using a dose–response meta-analysis to examine the shape of the relation. We retrieved 17 eligible studies through September 13, 2021, including ten cohort and seven case–control studies. In the analysis comparing highest versus lowest LAN exposure, we found a positive association between exposure and disease risk (risk ratio [RR] 1.11, 95% confidence interval-CI 1.07–1.15), with comparable associations in case–control studies (RR 1.14, 95% CI 0.98–1.34) and cohort studies (RR 1.10, 95% CI 1.06–1.15). In stratified analyses, risk was similar for outdoor and indoor LAN exposure, while slightly stronger risks were observed for premenopausal women (premenopausal: RR 1.16, 95% CI 1.04–1.28; postmenopausal: 1.07, 95% CI 1.02–1.13) and for women with estrogen receptor (ER) positive breast cancer (ER + : RR 1.09, 95% CI 1.02–1.17; ER–: RR 1.07, 95% CI 0.92–1.23). The dose–response meta-analysis, performed only in studies investigating outdoor LAN using comparable exposure assessment, showed a linear relation up to 40 nW/cm2/sr after which the curve flattened, especially among premenopausal women. This first assessment of the dose–response relation between LAN and breast cancer supports a positive association in selected subgroups, particularly in premenopausal women.

scholarly journals Use of Oral Contraceptives as a Potential Risk Factor for Breast Cancer: A Systematic Review and Meta-Analysis of Case-Control Studies Up to 2010

2021 ◽  
Vol 18 (9) ◽  
pp. 4638
Author(s):  
Wiesław Kanadys ◽  
Agnieszka Barańska ◽  
Maria Malm ◽  
Agata Błaszczuk ◽  
Małgorzata Polz-Dacewicz ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Systematic Review ◽  
Oral Contraceptives ◽  
Meta Analysis ◽  
Case Control ◽  
Full Term ◽  
Term Pregnancy ◽  
Case Control Studies ◽  
Nulliparous Women ◽  
Increased Risk

Despite numerous studies evaluating the risk of breast cancer among oral contraception users, the effect of oral contraceptive on developing breast cancer remains inconclusive. Therefore, we conducted a systematic review of literature with meta-analysis in order to quantitative estimate this association. The bibliographic database MEDLINE and EMBASE, and reference lists of identified articles were searched, with no language restrictions, from the start of publication to August 2010. We performed a reanalysis and overall estimate of 79 case-control studies conducted between 1960–2010, including a total of 72,030 incidents, histologically confirmed cases of breast cancer and 123,650 population/hospital controls. A decrease was observed in cancer risk in OC users before age 25 years (0.91, 0.83–1.00). However, the use of OCs before the first full-term pregnancy had a significant increased risk of breast cancer (OR, 1.14, 1.01–1.28, p = 0.04), as did OC use longer than 5 years (1.09, 1.01–1.18, p = 0.02). Pooled crude odds ratios of breast cancer in ever-users of oral contraceptives was 1.01 [95% confidence interval (CI), 0.95–1.07], compared with never-users. There was no significant increase in risk among premenopausal women (1.06, 0.92–1.22), postmenopausal women (0.99, 0.89–1.10), or nulliparous women (1.02, 0.82–1.26). Oral contraceptives do not appear to increase the risk of breast cancer among users. However, OC use before a first full-term pregnancy or using them longer than 5 years can modify the development of the breast cancer.

Does coffee, tea and caffeine consumption reduce the risk of incident breast cancer? A systematic review and network meta-analysis

2021 ◽  
pp. 1-13
Author(s):  
Shu Wang ◽  
Xiang Li ◽  
Yue Yang ◽  
Jingping Xie ◽  
Mingyue Liu ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Systematic Review ◽  
Postmenopausal Women ◽  
Meta Analysis ◽  
High Dose ◽  
Dependent Manner ◽  
Tea Consumption ◽  
Case Control Studies ◽  
High Concentration ◽  
Coffee Intake

Abstract Objective: We aimed to evaluate the association between coffee and/or tea consumption and breast cancer (BC) risk among premenopausal and postmenopausal women and to conduct a network meta-analysis. Design: Systematic review and network meta-analysis. Setting: We conducted a systematic review of electronic publications in the last 30 years to identify case–control studies or prospective cohort studies that evaluated the effects of coffee and tea intake. Results: Forty-five studies that included more than 3 323 288 participants were eligible for analysis. Network meta-analysis was performed to determine the effects of coffee and/or tea consumption on reducing BC risk in a dose-dependent manner and differences in coffee/tea type, menopause status, hormone receptor and the BMI in subgroup and meta-regression analyses. According to the first pairwise meta-analysis, low-dose coffee intake and high-dose tea intake may exhibit efficacy in preventing ER(estrogen receptor)− BC, particularly in postmenopausal women. Then, we performed another pairwise and network meta-analysis and determined that the recommended daily doses were 2–3 cups/d of coffee or ≥5 cups/d of tea, which contained a high concentration of caffeine, particularly in postmenopausal women. Conclusions: Coffee and tea consumption is not associated with a reduction in the overall BC risk in postmenopausal women and is associated with a potentially lower risk of ER− BC. And the highest recommended dose is 2–3 cups of coffee/d or ≥5 cups of tea/d. They are potentially useful dietary protectants for preventing BC.

Respiratory disturbances in fibromyalgia: a systematic review and meta-analysis of case control studies

2021 ◽  
Author(s):  
Araceli Ortiz-Rubio ◽  
Irene Torres-Sánchez ◽  
Irene Cabrera-Martos ◽  
Laura López-López ◽  
Janet Rodríguez-Torres ◽  
...  
Keyword(s):  
Systematic Review ◽  
Meta Analysis ◽  
Case Control ◽  
Case Control Studies
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