Modification of the ferric chloride assay for the spectrophotometric determination of ferric and total iron in acidic solutions containing high concentrations of copper
Abstract
A spectrophotometric method for determining Fe2+, Fe3+, and total Fe in drugs has been developed, using α, α′-dipyridyl as the colorimetric reagent. The method is applicable to tablets, elixirs, injectables, and bulk powders. Eight collaborators analyzed a synthetic iron preparation and 7 commercial samples. For the synthetic iron preparation, the average recovery was 100.3% and the coefficient of variation was 1.02%. For 7 commercial samples, the average coefficient of variation was 1.44%. The method has been adopted as official first action.
Improved Spectrophotometric Determination of Total Iron and Iron(III) with o-Hydroxyhydroquinonephthalein and Their Characterization
