Mitochondrial respiratory chain and creatine kinase activities in rat brain after sepsis induced by cecal ligation and perforation

Mitochondrion ◽  
2008 ◽  
Vol 8 (4) ◽  
pp. 313-318 ◽  
Author(s):  
Clarissa M. Comim ◽  
Gislaine T. Rezin ◽  
Giselli Scaini ◽  
Priscila B. Di-Pietro ◽  
Mariane R. Cardoso ◽  
...  
Keyword(s):  
Creatine Kinase ◽  
Rat Brain ◽  
Respiratory Chain ◽  
Cecal Ligation ◽  
Mitochondrial Respiratory Chain ◽  
Mitochondrial Respiratory

Effects of maintenance electroshock on mitochondrial respiratory chain and creatine kinase activities in the rat brain

2012 ◽  
Vol 24 (5) ◽  
pp. 275-285
Author(s):  
Gislaine Z. Réus ◽  
Roberto B. Stringari ◽  
Gislaine T. Rezin ◽  
Daiana P. Pezente ◽  
Giselli Scaini ◽  
...  
Keyword(s):  
Creatine Kinase ◽  
Energy Metabolism ◽  
Rat Brain ◽  
Respiratory Chain ◽  
Brain Area ◽  
Mitochondrial Respiratory Chain ◽  
Respiratory Chain Complexes ◽  
Chain Complexes ◽  
Male Wistar Rats ◽  
Mitochondrial Respiratory

Réus GZ, Stringari RB, Rezin GT, Pezente DP, Scaini G, Maggi DD, De-Nês BT, Streck EL, Quevedo J, Feier G. Effects of maintenance electroshock on mitochondrial respiratory chain and creatine kinase activities in the rat brain.Objective: Electroconvulsive therapy is used efficacious treatment for a variety of complicated psychiatric disorders and evidences have indicated that energy metabolism impairment may be involved in pathophysiology and treatment of mood disorders. This work was performed to determine creatine kinase and mitochondrial respiratory chain activities at different times after the maintenance electroconvulsive shock (ECS).Methods: Male Wistar rats received a protocol mimicking therapeutic of maintenance or simulated ECS (sham) and were subsequently sacrificed immediately after, 48 h and 7 days after the last maintenance ECS. We measured creatine kinase and mitochondrial respiratory chain activities in the prefrontal cortex, hippocampus, cortex, cerebellum and striatum.Results: Our results showed that maintenance ECS alter respiratory chain complexes and creatine kinase activities in the rat brain, but these effects were related to brain area and time after the ECS, in which the animal were killed.Conclusion: Finally, these findings further support the hypothesis that alteration on the energy metabolism could be involved in the therapeutic or adverse effects of ECS.

scholarly journals Administration of Harmine and Imipramine Alters Creatine Kinase and Mitochondrial Respiratory Chain Activities in the Rat Brain

2012 ◽  
Vol 2012 ◽  
pp. 1-7 ◽  
Author(s):  
Gislaine Z. Réus ◽  
Roberto B. Stringari ◽  
Cinara L. Gonçalves ◽  
Giselli Scaini ◽  
Milena Carvalho-Silva ◽  
...  
Keyword(s):  
Creatine Kinase ◽  
Rat Brain ◽  
Respiratory Chain ◽  
Complex I ◽  
Acute Treatment ◽  
Chronic Treatment ◽  
Mitochondrial Respiratory Chain ◽  
Complex Iv ◽  
Complex Ii ◽  
Mitochondrial Respiratory

The present study evaluated mitochondrial respiratory chain and creatine kinase activities after administration of harmine (5, 10, and 15 mg/kg) and imipramine (10, 20, and 30 mg/kg) in rat brain. After acute treatment occurred an increase of creatine kinase in the prefrontal with imipramine (20 and 30 mg/kg) and harmine in all doses, in the striatum with imipramine (20 and 30 mg/kg) and harmine (5 and 10 mg/kg); harmine (15 mg/kg) decreased creatine kinase. In the chronic treatment occurred an increase of creatine kinase with imipramine (20 mg/kg), harmine (5 mg/kg) in the prefrontal with imipramine (20 and 30 mg/kg) and harmine (5 and 10 mg/kg) in the striatum. In the acute treatment, the complex I increased in the prefrontal with harmine (15 mg/kg) and in the striatum with harmine (10 mg/kg); the complex II decreased with imipramine (20 and 30 mg/kg) in the striatum; the complex IV increased with imipramine (30 mg/kg) in the striatum. In the chronic treatment, the complex I increased with harmine (5 mg/kg) in the prefrontal; the complex II increased with imipramine (20 mg/kg) in the prefrontal; the complex IV increased with harmine (5 mg/kg) in the striatum. Finally, these findings further support the hypothesis that harmine and imipramine could be involved in mitochondrial function.

Administration of memantine and imipramine alters mitochondrial respiratory chain and creatine kinase activities in rat brain

2011 ◽  
Vol 119 (4) ◽  
pp. 481-491 ◽  
Author(s):  
Gislaine Z. Réus ◽  
Roberto B. Stringari ◽  
Gislaine T. Rezin ◽  
Daiane B. Fraga ◽  
Juliana F. Daufenbach ◽  
...  
Keyword(s):  
Creatine Kinase ◽  
Rat Brain ◽  
Respiratory Chain ◽  
Mitochondrial Respiratory Chain ◽  
Mitochondrial Respiratory

Effect of Electroconvulsive Shock on Mitochondrial Respiratory Chain in Rat Brain

2006 ◽  
Vol 31 (11) ◽  
pp. 1375-1379 ◽  
Author(s):  
Márcio Búrigo ◽  
Clarissa A. Roza ◽  
Cintia Bassani ◽  
Diego A. Fagundes ◽  
Gislaine T. Rezin ◽  
...  
Keyword(s):  
Rat Brain ◽  
Respiratory Chain ◽  
Electroconvulsive Shock ◽  
Mitochondrial Respiratory Chain ◽  
Mitochondrial Respiratory

Mitochondrial respiratory chain and creatine kinase activities following trauma brain injury in brain of mice preconditioned with N-methyl-d-aspartate

2013 ◽  
Vol 384 (1-2) ◽  
pp. 129-137 ◽  
Author(s):  
Carina R. Boeck ◽  
Leatrice S. Carbonera ◽  
Mônia E. Milioli ◽  
Leandra C. Constantino ◽  
Michelle L. Garcez ◽  
...  
Keyword(s):  
Creatine Kinase ◽  
Brain Injury ◽  
Respiratory Chain ◽  
Mitochondrial Respiratory Chain ◽  
Trauma Brain Injury ◽  
Mitochondrial Respiratory

Chronic Stress Causes Sex-Specific and Structure-Specific Alterations in Mitochondrial Respiratory Chain Activity in Rat Brain

2017 ◽  
Vol 42 (11) ◽  
pp. 3331-3340 ◽  
Author(s):  
Carina de Souza Mota ◽  
Simone Nardin Weis ◽  
Roberto Farina Almeida ◽  
Carla Dalmaz ◽  
Fátima Therezinha Costa Guma ◽  
...  
Keyword(s):  
Rat Brain ◽  
Chronic Stress ◽  
Respiratory Chain ◽  
Mitochondrial Respiratory Chain ◽  
Mitochondrial Respiratory Chain Activity ◽  
Respiratory Chain Activity ◽  
Mitochondrial Respiratory

Olanzapine plus fluoxetine treatment alters mitochondrial respiratory chain activity in the rat brain

2011 ◽  
Vol 23 (6) ◽  
pp. 282-291 ◽  
Author(s):  
Fabiano R. Agostinho ◽  
Gislaine Z. Réus ◽  
Roberto B. Stringari ◽  
Karine F. Ribeiro ◽  
Gabriela K. Ferreira ◽  
...  
Keyword(s):  
Rat Brain ◽  
Mood Disorders ◽  
Respiratory Chain ◽  
Mitochondrial Respiratory Chain ◽  
Respiratory Chain Complexes ◽  
Fluoxetine Treatment ◽  
Chain Complexes ◽  
Mitochondrial Respiratory Chain Activity ◽  
Respiratory Chain Activity ◽  
Mitochondrial Respiratory

Agostinho FR, Réus GZ, Stringari RB, Ribeiro KF, Ferreira GK, Jeremias IC, Scaini G, Rezin GT, Streck EL, Quevedo J. Olanzapine plus fluoxetine treatment alters mitochondrial respiratory chain activity in the rat brain.Background: Evidence is emerging for the role of dysfunctional mitochondria in pathophysiology and treatment of mood disorders. In this study, we evaluated the effects of acute and chronic administration of fluoxetine (FLX), olanzapine (OLZ) and the combination of FLX/OLZ on mitochondrial respiratory chain activity in the rat brain.Methods: For acute treatment, Wistar rats received one single injection of OLZ (3 or 6 mg/kg) and/or FLX (12 or 25 mg/kg) and for chronic treatment, rats received daily injections of OLZ (3 or 6 mg/kg) and/or FLX (12 or 25 mg/kg) for 28 days and we evaluated the activity of mitochondrial respiratory chain complexes I, II, II–III and IV in prefrontal cortex, hippocampus and striatum.Results: Our results showed that both acute and chronic treatments with FLX and OLZ alone or in combination altered respiratory chain complexes activity in the rat brain, but in combination we observed larger alterations.Conclusions: Finally, these findings further support the hypothesis that metabolism energy could be involved in the treatment with antipsychotics and antidepressants in combination to mood disorders.

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