Chronic treatment with coenzyme Q10 reverses restraint stress-induced anhedonia and enhances brain mitochondrial respiratory chain and creatine kinase activities in rats

The present study evaluated mitochondrial respiratory chain and creatine kinase activities after administration of harmine (5, 10, and 15 mg/kg) and imipramine (10, 20, and 30 mg/kg) in rat brain. After acute treatment occurred an increase of creatine kinase in the prefrontal with imipramine (20 and 30 mg/kg) and harmine in all doses, in the striatum with imipramine (20 and 30 mg/kg) and harmine (5 and 10 mg/kg); harmine (15 mg/kg) decreased creatine kinase. In the chronic treatment occurred an increase of creatine kinase with imipramine (20 mg/kg), harmine (5 mg/kg) in the prefrontal with imipramine (20 and 30 mg/kg) and harmine (5 and 10 mg/kg) in the striatum. In the acute treatment, the complex I increased in the prefrontal with harmine (15 mg/kg) and in the striatum with harmine (10 mg/kg); the complex II decreased with imipramine (20 and 30 mg/kg) in the striatum; the complex IV increased with imipramine (30 mg/kg) in the striatum. In the chronic treatment, the complex I increased with harmine (5 mg/kg) in the prefrontal; the complex II increased with imipramine (20 mg/kg) in the prefrontal; the complex IV increased with harmine (5 mg/kg) in the striatum. Finally, these findings further support the hypothesis that harmine and imipramine could be involved in mitochondrial function.

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The redox state of coenzyme Q10 in mitochondrial respiratory chain and oxygen-derived free radical generation in cardiac cells

Molecular Aspects of Medicine ◽

10.1016/s0098-2997(97)00034-4 ◽

1997 ◽

Vol 18 ◽

pp. 41-50 ◽

Cited By ~ 8

Author(s):

Enno K. Ruuge ◽

Konstantin P. Kashkarov ◽

Vladimir L. Lakomkin ◽

Alexander A. Timoshin ◽

Elena V. Vasil'eva

Keyword(s):

Free Radical ◽

Respiratory Chain ◽

Coenzyme Q10 ◽

Redox State ◽

Mitochondrial Respiratory Chain ◽

Cardiac Cells ◽

Free Radical Generation ◽

Radical Generation ◽

Mitochondrial Respiratory

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Coenzyme Q: potentially useful index of bioenergetic and oxidative status of spermatozoa

Clinical Chemistry ◽

10.1093/clinchem/41.2.217 ◽

1995 ◽

Vol 41 (2) ◽

pp. 217-219 ◽

Cited By ~ 10

Author(s):

A G Angelitti ◽

L Colacicco ◽

C Callà ◽

M Arizzi ◽

S Lippa

Keyword(s):

Respiratory Chain ◽

Coenzyme Q10 ◽

Coenzyme Q ◽

Mitochondrial Respiratory Chain ◽

Oxidative Status ◽

Atp Production ◽

The Difference ◽

Autoregulatory Mechanism ◽

Infertile Patients ◽

Mitochondrial Respiratory

Abstract The concentration of coenzyme Q10 (CoQ10), a key intermediate of the mitochondrial respiratory chain, was determined in spermatozoa of 13 fertile subjects, 8 potentially fertile patients, and 12 infertile patients. CoQ10 concentrations were significantly higher (P < 0.001) in infertile patients than in fertile and potentially fertile subjects. The difference between potentially fertile and fertile subjects was also significant (P < 0.001). We propose that a decrease in consumption of CoQ10 in both infertile and potentially fertile populations is due to an autoregulatory mechanism of ATP production.

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Effects of maintenance electroshock on mitochondrial respiratory chain and creatine kinase activities in the rat brain

Acta Neuropsychiatrica ◽

10.1111/j.1601-5215.2011.00629.x ◽

2012 ◽

Vol 24 (5) ◽

pp. 275-285

Author(s):

Gislaine Z. Réus ◽

Roberto B. Stringari ◽

Gislaine T. Rezin ◽

Daiana P. Pezente ◽

Giselli Scaini ◽

...

Keyword(s):

Creatine Kinase ◽

Energy Metabolism ◽

Rat Brain ◽

Respiratory Chain ◽

Brain Area ◽

Mitochondrial Respiratory Chain ◽

Respiratory Chain Complexes ◽

Chain Complexes ◽

Male Wistar Rats ◽

Mitochondrial Respiratory

Réus GZ, Stringari RB, Rezin GT, Pezente DP, Scaini G, Maggi DD, De-Nês BT, Streck EL, Quevedo J, Feier G. Effects of maintenance electroshock on mitochondrial respiratory chain and creatine kinase activities in the rat brain.Objective: Electroconvulsive therapy is used efficacious treatment for a variety of complicated psychiatric disorders and evidences have indicated that energy metabolism impairment may be involved in pathophysiology and treatment of mood disorders. This work was performed to determine creatine kinase and mitochondrial respiratory chain activities at different times after the maintenance electroconvulsive shock (ECS).Methods: Male Wistar rats received a protocol mimicking therapeutic of maintenance or simulated ECS (sham) and were subsequently sacrificed immediately after, 48 h and 7 days after the last maintenance ECS. We measured creatine kinase and mitochondrial respiratory chain activities in the prefrontal cortex, hippocampus, cortex, cerebellum and striatum.Results: Our results showed that maintenance ECS alter respiratory chain complexes and creatine kinase activities in the rat brain, but these effects were related to brain area and time after the ECS, in which the animal were killed.Conclusion: Finally, these findings further support the hypothesis that alteration on the energy metabolism could be involved in the therapeutic or adverse effects of ECS.

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