scholarly journals FANCA Promotes DNA Double-Strand Break Repair by Catalyzing Single-Strand Annealing and Strand Exchange

2018 ◽  
Vol 71 (4) ◽  
pp. 621-628.e4 ◽  
Author(s):  
Anaid Benitez ◽  
Wenjun Liu ◽  
Anna Palovcak ◽  
Guanying Wang ◽  
Jaewon Moon ◽  
...  
Keyword(s):  
Strand Break ◽  
Double Strand Break ◽  
Single Strand ◽  
Strand Exchange ◽  
Double Strand Break Repair ◽  
Dna Double Strand Break ◽  
Single Strand Annealing ◽  
Break Repair ◽  
Strand Annealing

scholarly journals The deinococcal DdrB protein is involved in an early step of DNA double strand break repair and in plasmid transformation through its single-strand annealing activity

DNA Repair ◽  
2011 ◽  
Vol 10 (12) ◽  
pp. 1223-1231 ◽  
Author(s):  
Claire Bouthier de la Tour ◽  
Stéphanie Boisnard ◽  
Cédric Norais ◽  
Magali Toueille ◽  
Esma Bentchikou ◽  
...  
Keyword(s):  
Strand Break ◽  
Double Strand Break ◽  
Single Strand ◽  
Double Strand Break Repair ◽  
Early Step ◽  
Plasmid Transformation ◽  
Dna Double Strand Break ◽  
Single Strand Annealing ◽  
Break Repair ◽  
Strand Annealing

scholarly journals Analysis of BRCA1 Variants in Double-Strand Break Repair by Homologous Recombination and Single-Strand Annealing

2013 ◽  
Vol 34 (3) ◽  
pp. 439-445 ◽  
Author(s):  
William I. Towler ◽  
Jie Zhang ◽  
Derek J. R. Ransburgh ◽  
Amanda E. Toland ◽  
Chikashi Ishioka ◽  
...  
Keyword(s):  
Homologous Recombination ◽  
Strand Break ◽  
Double Strand Break ◽  
Single Strand ◽  
Double Strand Break Repair ◽  
Single Strand Annealing ◽  
Break Repair ◽  
Strand Annealing

scholarly journals Aberrant Double-Strand Break Repair inrad51 Mutants of Saccharomyces cerevisiae

2000 ◽  
Vol 20 (24) ◽  
pp. 9162-9172 ◽  
Author(s):  
Leslie E. Kang ◽  
Lorraine S. Symington
Keyword(s):  
Saccharomyces Cerevisiae ◽  
Strand Break ◽  
Double Strand Break ◽  
Single Strand ◽  
Double Strand Break Repair ◽  
Inverted Repeats ◽  
Independent Events ◽  
Single Strand Annealing ◽  
Break Repair ◽  
Strand Annealing

ABSTRACT A number of studies of Saccharomyces cerevisiae have revealed RAD51-independent recombination events. These include spontaneous and double-strand break-induced recombination between repeated sequences, and capture of a chromosome arm by break-induced replication. Although recombination between inverted repeats is considered to be a conservative intramolecular event, the lack of requirement for RAD51 suggests that repair can also occur by a nonconservative mechanism. We propose a model forRAD51-independent recombination by one-ended strand invasion coupled to DNA synthesis, followed by single-strand annealing. The Rad1/Rad10 endonuclease is required to trim intermediates formed during single-strand annealing and thus was expected to be required forRAD51-independent events by this model. Double-strand break repair between plasmid-borne inverted repeats was less efficient inrad1 rad51 double mutants than in rad1 andrad51 strains. In addition, repair events were delayed and frequently associated with plasmid loss. Furthermore, the repair products recovered from the rad1 rad51 strain were primarily in the crossover configuration, inconsistent with conservative models for mitotic double-strand break repair.

A novel protein, Rsf1/Pxd1, is critical for the single-strand annealing pathway of double-strand break repair inSchizosaccharomyces pombe

2015 ◽  
Vol 96 (6) ◽  
pp. 1211-1225 ◽  
Author(s):  
Hanqian Wang ◽  
Zhanlu Zhang ◽  
Lan Zhang ◽  
Qiuxue Zhang ◽  
Liang Zhang ◽  
...  
Keyword(s):  
Strand Break ◽  
Double Strand Break ◽  
Single Strand ◽  
Double Strand Break Repair ◽  
Single Strand Annealing ◽  
Break Repair ◽  
Strand Annealing ◽  
Novel Protein
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