The role of complement in myocardial ischaemia/reperfusion injury and antibody-mediated rejection in a mouse heterotopic heart transplant model

2008 ◽  
Vol 45 (16) ◽  
pp. 4160-4161
Author(s):  
Carl Atkinson ◽  
Yongquan Gong ◽  
Yuxiang Huang ◽  
Emily Pauling ◽  
Martin Goddard ◽  
...  
Keyword(s):  
Reperfusion Injury ◽  
Myocardial Ischaemia ◽  
Heart Transplant ◽  
Ischaemia Reperfusion Injury ◽  
Antibody Mediated Rejection ◽  
Ischaemia Reperfusion ◽  
Transplant Model

scholarly journals BS31 The role of fractalkine and CX3CR1-expressing lymphocytes during myocardial ischaemia/reperfusion injury

2019 ◽  
Author(s):  
Lilia Draganova ◽  
Rachael Redgrave ◽  
Simon Tual-Chalot ◽  
Sarah Marsh ◽  
Helen Arthur ◽  
...  
Keyword(s):  
Reperfusion Injury ◽  
Myocardial Ischaemia ◽  
Ischaemia Reperfusion Injury ◽  
Ischaemia Reperfusion

scholarly journals Sildenafil-mediated neovascularization and protection against myocardial ischaemia reperfusion injury in rats: role of VEGF/angiopoietin-1

2008 ◽  
Vol 12 (6b) ◽  
pp. 2651-2664 ◽  
Author(s):  
Srikanth Koneru ◽  
Suresh Varma Penumathsa ◽  
Mahesh Thirunavukkarasu ◽  
Ramesh Vidavalur ◽  
Lijun Zhan ◽  
...  
Keyword(s):  
Reperfusion Injury ◽  
Myocardial Ischaemia ◽  
Ischaemia Reperfusion Injury ◽  
Ischaemia Reperfusion ◽  
Angiopoietin 1

scholarly journals Toll-like receptor 4 modulates myocardial ischaemia-reperfusion injury: Role of matrix metalloproteinases

2006 ◽  
Vol 8 (7) ◽  
pp. 665-672 ◽  
Author(s):  
Heidi Stapel ◽  
Se-Chan Kim ◽  
Steffen Osterkamp ◽  
Pascal Knuefermann ◽  
Andreas Hoeft ◽  
...  
Keyword(s):  
Matrix Metalloproteinases ◽  
Reperfusion Injury ◽  
Myocardial Ischaemia ◽  
Toll Like Receptor ◽  
Toll Like Receptor 4 ◽  
Ischaemia Reperfusion Injury ◽  
Ischaemia Reperfusion

scholarly journals miRNA-146a Mimic Inhibits NOX4/P38 Signalling to Ameliorate Mouse Myocardial Ischaemia Reperfusion (I/R) Injury

2021 ◽  
Vol 2021 ◽  
pp. 1-10
Author(s):  
Lili Xiao ◽  
Yulei Gu ◽  
Gaofei Ren ◽  
Linlin Chen ◽  
Liming Liu ◽  
...  
Keyword(s):  
Reperfusion Injury ◽  
Myocardial Ischaemia ◽  
Underlying Mechanism ◽  
Neonatal Rat ◽  
Ischaemia Reperfusion Injury ◽  
Rat Cardiomyocytes ◽  
Ischaemia Reperfusion ◽  
Ros Accumulation

Evidence suggests that miR-146a is implicated in the pathogenesis of cardiovascular diseases; however, the role of miR-146a in myocardial ischaemia reperfusion (I/R) injury is unclear. The aim of this study was to explore the functional role of miR-146a in myocardial ischaemia reperfusion injury and the underlying mechanism. C57BL/6J mice were subjected to 45 min of ischaemia and 1 week of reperfusion to establish a myocardial I/R injury model. A miR-146a mimic (0.5 mg/kg) was administered intravenously at the beginning of the ischaemia process. Neonatal rat cardiomyocytes were also subjected to hypoxia/reperfusion (H/R). Cells were treated with the miR-146a mimic or antagonist. As a result, the miR-146a mimic attenuated H/R-induced cardiomyocyte injury, as evidenced by increased cell viability and reduced lactate dehydrogenase (LDH) levels. In addition, the miR-146a mimic inhibited oxidative stress in cells suffering from H/R injury. Moreover, the miR-146a antagonist exerted adverse effects in vitro. In mice with myocardial I/R injury, the miR-146a mimic preserved cardiac function and reduced the infarction area and fibrosis. Moreover, the miR-146a mimic decreased the inflammatory response and reactive oxygen species (ROS) accumulation in mouse hearts. Mechanistically, we found that miR-146a directly regulated the transcription of NOX4, which subsequently affected P38 signalling in cardiomyocytes. When we knocked down NOX4, the effects of the miR-146a antagonist in worsening the cell condition were counteracted in in vitro experiments. Taken together, the results suggest that miR-146a protects against myocardial ischaemia reperfusion injury by inhibiting NOX4 signalling. The miR-146a mimic may become a potential therapeutic approach for patients with myocardial ischaemia reperfusion.

Role of microRNA-195 in cardiomyocyte apoptosis induced by myocardial ischaemia–reperfusion injury

2016 ◽  
Vol 95 (1) ◽  
pp. 99-108 ◽  
Author(s):  
CHANG-KUI GAO ◽  
HUI LIU ◽  
CHENG-JI CUI ◽  
ZHAO-GUANG LIANG ◽  
HONG YAO ◽  
...  
Keyword(s):  
Reperfusion Injury ◽  
Myocardial Ischaemia ◽  
Cardiomyocyte Apoptosis ◽  
Ischaemia Reperfusion Injury ◽  
Ischaemia Reperfusion

Role of insulin receptors in myocardial ischaemia-reperfusion injury during cardiopulmonary bypass

2011 ◽  
Vol 66 (3) ◽  
pp. 323-331 ◽  
Author(s):  
Gui-You Liang ◽  
Han-Sheng Wu ◽  
Jian Li ◽  
Qing-Yong Cai ◽  
Zheng-Yu Gao
Keyword(s):  
Cardiopulmonary Bypass ◽  
Reperfusion Injury ◽  
Myocardial Ischaemia ◽  
Insulin Receptors ◽  
Ischaemia Reperfusion Injury ◽  
Ischaemia Reperfusion

scholarly journals 229 Role of sumoylation and desumoylation of mitochondrial fission proteins in myocardial ischaemia-reperfusion injury

Heart ◽  
2017 ◽  
Vol 103 (Suppl 5) ◽  
pp. A147-A148
Author(s):  
Nadiia Rawlings ◽  
Laura Lee ◽  
Jordan Martin ◽  
Richard Seager ◽  
Chun Guo ◽  
...  
Keyword(s):  
Reperfusion Injury ◽  
Myocardial Ischaemia ◽  
Mitochondrial Fission ◽  
Ischaemia Reperfusion Injury ◽  
Ischaemia Reperfusion

scholarly journals The role of gasotransmitters NO, H2S and CO in myocardial ischaemia/reperfusion injury and cardioprotection by preconditioning, postconditioning and remote conditioning

2014 ◽  
Vol 172 (6) ◽  
pp. 1587-1606 ◽  
Author(s):  
Ioanna Andreadou ◽  
Efstathios K Iliodromitis ◽  
Tienush Rassaf ◽  
Rainer Schulz ◽  
Andreas Papapetropoulos ◽  
...  
Keyword(s):  
Reperfusion Injury ◽  
Myocardial Ischaemia ◽  
Ischaemia Reperfusion Injury ◽  
Ischaemia Reperfusion ◽  
Remote Conditioning
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