Solubility of dilute SO 2 in binary system of polyethylene glycol 200 and dimethyl sulfoxide as a function of liquid composition and system's spectroscopic studies

2017 ◽  
Vol 225 ◽  
pp. 151-159 ◽  
Author(s):  
Tianxiang Zhao ◽  
Xi Feng ◽  
Wentao Zheng ◽  
Xingbang Hu ◽  
Jianbin Zhang ◽  
...  
Keyword(s):  
Polyethylene Glycol ◽  
Binary System ◽  
Dimethyl Sulfoxide ◽  
Spectroscopic Studies ◽  
Liquid Composition ◽  
Polyethylene Glycol 200

Excess properties and spectroscopic studies of binary system of 1-methoxy-2-propanol + dimethyl sulfoxide atT= (298.15–318.15) K

2015 ◽  
Vol 54 (3) ◽  
pp. 411-421 ◽  
Author(s):  
Xinxin Ju ◽  
Tianxiang Zhao ◽  
Feng Sha ◽  
Bo Guo ◽  
Xiaohong Xie ◽  
...  
Keyword(s):  
Binary System ◽  
Dimethyl Sulfoxide ◽  
Spectroscopic Studies ◽  
Excess Properties

Density, viscosity and spectroscopic studies of the binary system of ethylene glycol+dimethyl sulfoxide at T=(298.15 to 323.15) K

2015 ◽  
Vol 207 ◽  
pp. 315-322 ◽  
Author(s):  
Tianxiang Zhao ◽  
Jianbin Zhang ◽  
Bo Guo ◽  
Fei Zhang ◽  
Feng Sha ◽  
...  
Keyword(s):  
Binary System ◽  
Ethylene Glycol ◽  
Dimethyl Sulfoxide ◽  
Spectroscopic Studies

scholarly journals A cautionary note: Toxicity of polyethylene glycol 200 injected intraperitoneally into mice

2019 ◽  
Vol 54 (4) ◽  
pp. 391-396
Author(s):  
Wilko Thiele ◽  
Lenka Kyjacova ◽  
Almut Köhler ◽  
Jonathan P Sleeman
Keyword(s):  
Polyethylene Glycol ◽  
Dimethyl Sulfoxide ◽  
Organic Solvents ◽  
Cautionary Note ◽  
Common Assumption ◽  
Regulatory Authorities ◽  
Polyethylene Glycol 200 ◽  
Hydrophobic Substances ◽  
The Common

The parenteral administration of hydrophobic substances in vivo requires the use of organic solvents to ensure sufficient solubility and avoid precipitation. Dimethyl sulfoxide is commonly used for this purpose. Based on the common assumption that polyethylene glycol (PEG) is non-toxic, our local regulatory authorities recently recommended the use of PEG instead. However, mice injected intraperitoneally (i.p.) with PEG 200 at a dose of 8 mL/kg (i.e. 9 g/kg) did not tolerate PEG 200 well, and half of the animals had to be euthanized. Our results demonstrate that although PEG 200 is generally considered to be harmless, it can be toxic when injected i.p. and is painful for the recipient mice. Nevertheless, it can be used as a solvent for repeated i.p. injections in mice at a dose of 2 mL/kg (i.e. 2.25 g/kg) without obvious signs of systemic toxicity.

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