Molecular Self-assemblies in Water and Brine and Solution Properties for a Hybrid Fluorocarbon Surfactant

The solution properties and phase behavior of ammonium hexylene octyl succinate (HOS) was investigated in water and water-oil system. The critical micelle concentration (CMC) of HOS is lower than that of anionic surfactants having same carbon number in the lipophilic part. The phase diagrams of a water/ HOS system and water/ HOS/ C10EO8/ dodecane system were also constructed. Above critical micelle concentration, the surfactant forms a normal micellar solution (Wm) at a low surfactant concentration whereas a lamellar liquid crystalline phase (La) dominates over a wide region through the formation of a two-phase region (La+W) in the binary system. The lamellar phase is arranged in the form of a biocompatible vesicle which is very significant for the drug delivery system. The surfactant tends to be hydrophilic when it is mixed with C10EO8 and a middle-phase microemulsion (D) is appeared in the water-surfactant-dodecane system where both the water and oil soluble drug ingredient can be incorporated in the form of a dispersion. Hence, mixing can tune the hydrophile-lipophile properties of the surfactant. Key words: Ammonium hexylene octyl succinate, mixed surfactant, lamellar liquid crystal, middle-phase microemulsion. Dhaka Univ. J. Pharm. Sci. Vol.3(1-2) 2004 The full text is of this article is available at the Dhaka Univ. J. Pharm. Sci. website

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Effect of Solution Properties and Operating Parameters on Needleless Electrospinning of Poly(Ethylene Oxide) Nanofibers Loaded with Bovine Serum Albumin

Current Drug Delivery ◽

10.2174/1567201816666191029122445 ◽

2019 ◽

Vol 16 (10) ◽

pp. 913-922 ◽

Cited By ~ 4

Author(s):

Ramprasath Ramakrishnan ◽

Jolius Gimbun ◽

Praveen Ramakrishnan ◽

Balu Ranganathan ◽

Samala Murali Mohan Reddy ◽

...

Keyword(s):

Bovine Serum Albumin ◽

Serum Albumin ◽

Bovine Serum ◽

Salt Content ◽

Electrospinning Process ◽

Solution Viscosity ◽

Operating Parameters ◽

Solution Properties ◽

Wire Electrode ◽

Needleless Electrospinning

Background: This paper presents the effect of solution properties and operating parameters of polyethylene oxide (PEO) based nanofiber using a wire electrode-based needleless electrospinning. Methods: The feed solution was prepared using a PEO dissolved in water or a water-ethanol mixture. The PEO solution is blended with Bovine Serum Albumin protein (BSA) as a model drug to study the effect of the electrospinning process on the stability of the loaded protein. The polymer solution properties such as viscosity, surface tension, and conductivity were controlled by adjusting the solvent and salt content. The morphology and fiber size distribution of the nanofiber was analyzed using scanning electron microscopy. Results: The results show that the issue of a beaded nanofiber can be eliminated either by increasing the solution viscosity or by the addition of salt and ethanol to the PEO-water system. The addition of salt and solvent produced a high frequency of smaller fiber diameter ranging from 100 to 150 nm. The encapsulation of BSA in PEO nanofiber was characterized by three different spectroscopy techniques (i.e. circular dichroism, Fourier transform infrared, and fluorescence) and the results showed the BSA is well encapsulated in the PEO matrix with no changes in the protein structure. Conclusion: This work may serve as a useful guide for a drug delivery industry to process a nanofiber at a large and continuous scale with a blend of drugs in nanofiber using a wire electrode electrospinning.

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Synthesis and solution properties of deferoxamine amides

Journal of Pharmaceutical Sciences ◽

10.1002/1520-6017(200012)89:12<1525::aid-jps3>3.3.co;2-k ◽

2000 ◽

Vol 89 (12) ◽

pp. 1525-1536 ◽

Cited By ~ 1

Author(s):

Peter M. Ihnat ◽

Jonathan L. Vennerstrom ◽

Dennis H. Robinson

Keyword(s):

Solution Properties

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Association of Graft Copolymers of Alkyl Methacrylates with α-Methyl-ω-hydroxy-poly(oxyethylene) ethacrylates

Collection of Czechoslovak Chemical Communications ◽

10.1135/cccc19951971 ◽

1995 ◽

Vol 60 (11) ◽

pp. 1971-1985 ◽

Cited By ~ 6

Author(s):

Čestmír Koňák ◽

Zdeněk Tuzar ◽

Pavla Kopečková ◽

Joseph D. Andrade ◽

Jindřich Kopeček

Keyword(s):

Light Scattering ◽

Graft Copolymers ◽

Water Solution ◽

Pure Water ◽

Solution Properties ◽

Monomer Composition ◽

Special Procedure ◽

Methyl Cellosolve ◽

Hexyl Methacrylate ◽

Alkyl Methacrylates

Solution properties of the statistical copolymers of alkyl methacrylates (AMA) with α-methyl-ω-hydroxy-poly(oxyethylene) methacrylates (MPOEMA) (nonionic polysoaps) were studied using static and dynamic ligh scattering as a function of monomer composition and concentration in aqueous and methyl cellosolve solutions. The solubility of the copolymers in water was found to be dependent on molar contant of AMA. While copolymers with low content of hexyl methacrylate (HMA) (0 and 20 mole %) were directly soluble in water, forming true solutions with a low content of large swollen aggregates, copolymers with a higher content of HMA or lauryl methacrylate (LMA) were not directly dispersable in water. A special procedure, the stepwise dialysis from methyl cellosolve solutions against water, had to be used to prepare them in the pseudomicellar form. The copolymers were directly soluble in methyl cellosolve and its water solution containing up to 60 vol.% of water. Nevertheless, the light scattering experiments were dominated by light scattering of swollen particles of aggregated copolymer molecules. The copolymers were not soluble in the mixtures containing 70-100 vol.% of water. Paramaters of aggregates in the mixture with 60 vol.% of water and in pure water were found to be very similar.

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