Design, synthesis, herbicidal activity, in vivo enzyme activity evaluation and molecular docking study of acylthiourea derivatives as novel acetohydroxyacid synthase inhibitor

2021 ◽  
pp. 130627
Author(s):  
Yun-Peng Wu ◽  
Yan Wang ◽  
Jia-Hui Li ◽  
Ran-Hong Li ◽  
Jun Wang ◽  
...  
Keyword(s):  
Enzyme Activity ◽  
Molecular Docking ◽  
Docking Study ◽  
Herbicidal Activity ◽  
Acetohydroxyacid Synthase ◽  
Molecular Docking Study ◽  
Design Synthesis ◽  
Activity Evaluation ◽  
Synthase Inhibitor

Design, Synthesis, Activity Evaluation and Molecular Docking Study of Novel Janus kinase Inhibitors

2021 ◽  
Vol 6 (17) ◽  
pp. 4212-4216
Author(s):  
Wenjun Du ◽  
Fuli Zhang ◽  
Pei Yan ◽  
Qingfu Lai ◽  
Junjian Li ◽  
...  
Keyword(s):  
Molecular Docking ◽  
Kinase Inhibitors ◽  
Docking Study ◽  
Janus Kinase ◽  
Molecular Docking Study ◽  
Design Synthesis ◽  
Janus Kinase Inhibitors ◽  
Activity Evaluation ◽  
Synthesis Activity

scholarly journals Design, synthesis, molecular docking, and in vitro α-glucosidase inhibitory activities of novel 3-amino-2,4-diarylbenzo[4,5]imidazo[1,2-a]pyrimidines against yeast and rat α-glucosidase

2021 ◽  
Vol 11 (1) ◽  
Author(s):  
Fariba Peytam ◽  
Ghazaleh Takalloobanafshi ◽  
Toktam Saadattalab ◽  
Maryam Norouzbahari ◽  
Zahra Emamgholipour ◽  
...  
Keyword(s):  
Molecular Docking ◽  
Docking Study ◽  
Rat Small Intestine ◽  
Molecular Docking Study ◽  
Design Synthesis ◽  
Mild Conditions ◽  
Glucosidase Inhibitors ◽  
Inhibitory Activities

AbstractIn an attempt to find novel, potent α-glucosidase inhibitors, a library of poly-substituted 3-amino-2,4-diarylbenzo[4,5]imidazo[1,2-a]pyrimidines 3a–ag have been synthesized through heating a mixture of 2-aminobenzimidazoles 1 and α-azidochalcone 2 under the mild conditions. This efficient, facile protocol has been resulted into the desirable compounds with a wide substrate scope in good to excellent yields. Afterwards, their inhibitory activities against yeast α-glucosidase enzyme were investigated. Showing IC50 values ranging from 16.4 ± 0.36 µM to 297.0 ± 1.2 µM confirmed their excellent potency to inhibit α-glucosidase which encouraged us to perform further studies on α-glucosidase enzymes obtained from rat as a mammal source. Among various synthesized 3-amino-2,4-diarylbenzo[4,5]imidazo[1,2-a]pyrimidines, compound 3k exhibited the highest potency against both Saccharomyces cerevisiae α-glucosidase (IC50 = 16.4 ± 0.36 μM) and rat small intestine α-glucosidase (IC50 = 45.0 ± 8.2 μM). Moreover, the role of amine moiety on the observed activity was studied through substituting with chlorine and hydrogen resulted into a considerable deterioration on the inhibitory activity. Kinetic study and molecular docking study have confirmed the in-vitro results.

Streptochlorin analogues as potential antifungal agents: Design, synthesis, antifungal activity and molecular docking study

2021 ◽  
Vol 35 ◽  
pp. 116073
Author(s):  
Ya Gao ◽  
Dai-Chuan Huang ◽  
Chang Liu ◽  
Zi-Long Song ◽  
Jing-Rui Liu ◽  
...  
Keyword(s):  
Molecular Docking ◽  
Antifungal Activity ◽  
Antifungal Agents ◽  
Docking Study ◽  
Molecular Docking Study ◽  
Design Synthesis
Sign in / Sign up

Export Citation Format

Share Document