Vascular neoplasms of the breast

Subglottic hemagioma is a rare cause of stridor, but it is one of the most common vascular neoplasms of the airways in childhood. If the treatment is not promptly instituted, it becomes a life-threatening condition. The diagnosis should be suspected when infants outside the age range for acute laryngitis present with stridor associated with severe respiratory effort, without viral prodromes, with a condition that is not responsive to initial therapeutic measures considering the main diagnostic hypothesis. Infantile hemangiomas begin to proliferate during the first year of life (between the 1st and 2nd month of life). Involution usually occurs between 6 months and 12 months of life (most involution until 4 years). The case is a 5-month-old female infant, with sudden stridor associated with respiratory distress without viral prodromes or fever, with little response to inhaled short-acting beta-agonist, inhaled adrenaline, as well as corticosteroids inhalation/parenteral. Bronchoscopy showed a bulging of the submucosa to the right of the subglottis with slight vascularization, suggestive of subglottic hemangioma. Treatment with propranolol was initiated orally with the aim of regressing the hemangioma and after clinical stability, the infant was discharged with outpatient follow-up.

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Cutaneous Vascular Neoplasms of Uncertain Biological Behavior

Biology ◽

10.3390/biology10111160 ◽

2021 ◽

Vol 10 (11) ◽

pp. 1160

Author(s):

Kasey J. McCollum ◽

Rami N. Al-Rohil

Keyword(s):

Case Series ◽

Epithelioid Hemangioendothelioma ◽

Biological Behavior ◽

Surgical Strategies ◽

Pseudomyogenic Hemangioendothelioma ◽

Vascular Neoplasms ◽

Indeterminate Lesion ◽

Comprehensive Framework ◽

National Databases

Neoplasms of uncertain biological behavior present physicians with a genuine conundrum in practice. Cutaneous vascular neoplasms within this category are exceedingly rare, possessing significant gaps and uncertainty in many facets of clinical practice. Firstly, lesions were selected for review based on their categorization as indeterminate behavior, indicating the potential for local recurrence and rarely metastasize. After identification of the target lesions, a comprehensive review of the literature using national databases produced several landmark studies and case series regarding these neoplasms. Limiting the review to only cutaneous limited tumors narrowed the pool of studies; however, quite a large sum of papers remained. Examination of each paper yielded beneficial results on diagnosing, effective treatments, follow-up findings, and prognosis for each indeterminate lesion discussed. Overall, the literature search combined the molecular, histologic, immunohistochemical, surgical strategies to develop an up-to-date and comprehensive framework to guide physicians when encountering such lesions. The tumors reviewed include: kaposiform hemangioendothelioma, endovascular papillary angioendothelioma, pseudomyogenic hemangioendothelioma, retiform hemangioendothelioma, epithelioid hemangioendothelioma, and composite hemangioendothelioma.

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Core Biopsy of Vascular Neoplasms of the Breast

The American Journal of Surgical Pathology ◽

10.1097/pas.0000000000000668 ◽

2016 ◽

Vol 40 (10) ◽

pp. 1424-1434 ◽

Cited By ~ 7

Author(s):

Jose G. Mantilla ◽

Tova Koenigsberg ◽

Beatriu Reig ◽

Nella Shapiro ◽

Esperanza Villanueva-Siles ◽

...

Keyword(s):

Core Biopsy ◽

Vascular Neoplasms

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Vascular neoplasms of the spleen

Diagnostic Histopathology ◽

10.1016/j.mpdhp.2016.10.001 ◽

2016 ◽

Vol 22 (12) ◽

pp. 473-478 ◽

Cited By ~ 3

Author(s):

Kossivi Dantey ◽

Kumarasen Cooper

Keyword(s):

Vascular Neoplasms

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Histologic and Immunohistochemical Characterization of Hemangiomas in the Skin of Seven Young Horses

Veterinary Pathology ◽

10.1177/030098589603300203 ◽

1996 ◽

Vol 33 (2) ◽

pp. 142-149 ◽

Cited By ~ 29

Author(s):

G. C. Johnson ◽

M. A. Miller ◽

J. L. Floss ◽

J. R. Turk

Keyword(s):

Smooth Muscle Actin ◽

Vascular Tumors ◽

Vascular Endothelial ◽

Vascular Walls ◽

Vascular Neoplasms ◽

Innermost Layer ◽

Nodular Growth ◽

Young Horses ◽

Time Of Presentation

The histologic and immunochemical characteristics of benign vascular tumors excised from the skin of seven young horses were evaluated. The patients were male horses of various breeds and were 16 months of age or younger at the time of presentation. Six tumors occurred on the extremities, and one was removed from the lip. Histologically, most tumors consisted of cellular nodules of varying compactness with few to many blood-filled lumina. Nodular growth separated preexisting adnexa and subcutaneous collagen. Some tumors contained or consisted predominantly of loosely packed arrays of ramifying arteries, veins, and capillaries separated by collagen within the dermis and subcutis. Within areas of nodular growth, multilayered vascular walls were encircled by reticulin strands that surrounded the endothelium and adjacent pericytes and also separated nonperivascular cells in the mass. Immunohistochemical staining of factor-VIII-related antigen and labeling by Ulex europeus-1 lectin was restricted to an innermost layer of cells surrounding vascular spaces, confirming their vascular endothelial origin. The plump fusiform cells arranged concentrically around the endothelium and some of those unassociated with vascular lumina stained with antibody to α-smooth muscle actin, as did the muscularis of larger vessels inside and outside of tumor nodules. These findings demonstrate an orderly arrangement between endothelium and supportive cells in these benign vascular neoplasms of young horses, similar to that observed during vascular development.

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