Effective encapsulation of a new cationic gadolinium chelate into apoferritin and its evaluation as an MRI contrast agent

2011 ◽  
Vol 7 (5) ◽  
pp. 638-646 ◽  
Author(s):  
Akira Makino ◽  
Hiroshi Harada ◽  
Tomohisa Okada ◽  
Hiroyuki Kimura ◽  
Hiroo Amano ◽  
...  
Keyword(s):  
Contrast Agent ◽  
Mri Contrast Agent ◽  
Mri Contrast ◽  
Gadolinium Chelate

Zeolitic imidazolate framework nanoparticles loaded with gadolinium chelate as efficient T1 MRI contrast agent

2021 ◽  
Vol 56 (12) ◽  
pp. 7386-7396
Author(s):  
Weixiu Zhou ◽  
Jiyun Shen ◽  
Jiaomin Lin ◽  
Miao An ◽  
Lu An ◽  
...  
Keyword(s):  
Contrast Agent ◽  
Mri Contrast Agent ◽  
Zeolitic Imidazolate Framework ◽  
Mri Contrast ◽  
Gadolinium Chelate

Gadolinium chelate with DO3A conjugated 2-(diphenylphosphoryl)-ethyldiphenylphosphonium cation as potential tumor-selective MRI contrast agent

Biomaterials ◽  
2012 ◽  
Vol 33 (36) ◽  
pp. 9225-9231 ◽  
Author(s):  
Prashant Chandrasekharan ◽  
Cai-Xian Yong ◽  
Zihan Poh ◽  
Tao He ◽  
Zhengjie He ◽  
...  
Keyword(s):  
Contrast Agent ◽  
Mri Contrast Agent ◽  
Mri Contrast ◽  
Gadolinium Chelate ◽  
Tumor Selective

Synthesis and Characterization of Poly(l-glutamic acid) Gadolinium Chelate:  A New Biodegradable MRI Contrast Agent

2004 ◽  
Vol 15 (6) ◽  
pp. 1408-1415 ◽  
Author(s):  
Xiaoxia Wen ◽  
Edward F. Jackson ◽  
Roger E. Price ◽  
E. Edmund Kim ◽  
Qingping Wu ◽  
...  
Keyword(s):  
Contrast Agent ◽  
Glutamic Acid ◽  
Mri Contrast Agent ◽  
Synthesis And Characterization ◽  
Mri Contrast ◽  
Gadolinium Chelate

Synthesis and Evaluation of a Biocompatible Macromolecular Gadolinium Compound as a Liver-Specific Contrast Agent for MRI

2017 ◽  
Vol 70 (3) ◽  
pp. 307 ◽  
Author(s):  
Youyang Zhan ◽  
Rong Xue ◽  
Mengchao Zhang ◽  
Chuanling Wan ◽  
Xiaojing Li ◽  
...  
Keyword(s):  
Contrast Agent ◽  
Mri Contrast Agent ◽  
Resonance Imaging ◽  
Mri Contrast ◽  
Gadolinium Chelate ◽  
Liver Specific Contrast Agent ◽  
Magnetic Resonance Imaging Mri ◽  
Gadolinium Compound

A new macromolecular biocompatible gadolinium chelate complex (PAI-N2-DOTA-Gd) as a liver-specific magnetic resonance imaging (MRI) contrast agent was synthesised and evaluated. An aspartic acid–isoleucine copolymer was chemically linked with Gd-DOTA via ethylenediamine to give PAI-N2-DOTA-Gd. In vitro, the T1-relaxivity of PAI-N2-DOTA-Gd (14.38 mmol–1⋅L⋅s–1, 0.5 T) was much higher than that of the clinically used Gd-DOTA (4.96 mmol–1⋅L⋅s–1, 0.5 T), with obvious imaging signal enhancement. In the imaging experiments in vivo, PAI-N2-DOTA-Gd exhibited good liver selectivity, and had a greater intensity enhancement (68.8 ± 5.6 %) and a longer imaging window time (30–70 min), compared to Gd-DOTA (21.1 ± 5.3 %, 10–30 min). Furthermore, the in vivo histological studies of PAI-N2-DOTA-Gd showed a low acute toxicity and desirable biocompatibility. The results of this study indicate that PAI-N2-DOTA-Gd is a feasible liver-specific contrast agent for MRI.

Anti-EpCAM scFv gadolinium chelate: a novel targeted MRI contrast agent for imaging of colorectal cancer

2018 ◽  
Vol 31 (5) ◽  
pp. 633-644 ◽  
Author(s):  
Kannika Khantasup ◽  
Pairash Saiviroonporn ◽  
Suwatchai Jarussophon ◽  
Warangkana Chantima ◽  
Tararaj Dharakul
Keyword(s):  
Colorectal Cancer ◽  
Contrast Agent ◽  
Mri Contrast Agent ◽  
Mri Contrast ◽  
Gadolinium Chelate ◽  
Targeted Mri

scholarly journals Evaluation of non-targeting, C- or N-pH (low) insertion peptide modified superparamagnetic iron oxide nanoclusters for selective MRI of liver tumors and their potential toxicity in cirrhosis

RSC Advances ◽  
2019 ◽  
Vol 9 (25) ◽  
pp. 14051-14059
Author(s):  
Abdulrahman Ahmed Mahmood ◽  
Jianqi Zhang ◽  
Rufang Liao ◽  
Xiwei Pan ◽  
Dan Xu ◽  
...  
Keyword(s):  
Iron Oxide ◽  
Liver Cancer ◽  
Contrast Agent ◽  
Cancer Diagnosis ◽  
Liver Tumors ◽  
Superparamagnetic Iron Oxide ◽  
Mri Contrast Agent ◽  
Potential Toxicity ◽  
Mri Contrast ◽  
Specific Enhancement

The acid-responsive pHLIP modified SPION as an MRI contrast agent for liver cancer diagnosis requires the validation of both the tumor-specific enhancement and a safe profile in cirrhosis.

Gd2O3 nanoparticles as a positive MRI contrast agent for cell uptake

2010 ◽  
Author(s):  
N. Riyahi-Alam ◽  
J. Behrouzkia ◽  
S. Haghgoo ◽  
A Seifalian ◽  
R Zohdi Aghdam. ◽  
...  
Keyword(s):  
Contrast Agent ◽  
Mri Contrast Agent ◽  
Cell Uptake ◽  
Mri Contrast ◽  
Gd2o3 Nanoparticles
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