In this chapter we describe a novel pedagogy for conceptual thinking and peer cooperation with Meaning Equivalence Reusable Learning Objects (MERLO) that enhances higher-order thinking; deepen comprehension of conceptual content; and improves learning outcomes. The evolution of this instructional methodology follows insights from four recent developments: analysis of patterns of content and structure of labeled patterns in human experience, that led to the emergence of concept science; development of digital cyber-infrastructure of networked information; research in neuroscience and brain imaging, showing that exposure of learners to multi-semiotic inductive problems enhance cognitive control of inter-hemispheric attentional processing in the lateral brain, and increase higher-order thinking; research in evolutionary dynamics on peer cooperation and indirect reciprocity, that document the motivational effect of knowledge of being observed, a psychological imperative that motivate individuals to cooperate and to contribute to the common good.