The metabolism of histamine in rat hypothalamus and cortex after reserpine treatment

2015 ◽  
Vol 85-86 ◽  
pp. 31-39 ◽  
Author(s):  
Martin Maldonado ◽  
Kazutaka Maeyama
1989 ◽  
Vol 54 (1) ◽  
pp. 225-228 ◽  
Author(s):  
Irena Červená ◽  
Jiří Holubek ◽  
Emil Svátek ◽  
Jan Metyš ◽  
Martin Valchář ◽  
...  

Heating of 4-methoxydibenzo[b,e]thiepin-11(6H)-one with pyridine hydrochloride to 225 to 235 °C effected demethylation and gave IV. Its sodium salt reacted with 3-dimethylaminopropyl chloride in ethanol and afforded the 4-(3-dimethylaminopropoxy) compound II. The isomeric ether III was prepared via the 4-(4-bromobutoxy) compound V. Hydrochloride of II (VÚFB-17 033) inhibited mildly the binding of [3H]desipramine in rat hypothalamus, had antireserpine activity in rats, mild anticonvulsant effect, and antihypoxic effect in the test of nitrogen anoxia in mice.


1990 ◽  
Vol 52 ◽  
pp. 288
Author(s):  
Takatoshi Mochizuki ◽  
Atsushi Yamatodani ◽  
Kaori Okakura ◽  
Motohiko Takemura ◽  
Naoyuki Inagaki ◽  
...  

2006 ◽  
Vol 573 (3) ◽  
pp. 711-721 ◽  
Author(s):  
Aude Panatier ◽  
Stephen J. Gentles ◽  
Charles W. Bourque ◽  
Stéphane H. R. Oliet

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