Spatial working memory deficits are shown in the rat with abnormal hippocampal neurogenesis, but not in the rat with abnormal cerebellar neurogenesis

2009 ◽  
Vol 65 ◽  
pp. S235
Author(s):  
Kozo Sugioka ◽  
Tomiyoshi Setsu ◽  
Toshio Terashima
Keyword(s):  
Working Memory ◽  
Spatial Working Memory ◽  
Memory Deficits ◽  
Hippocampal Neurogenesis

scholarly journals Mice Lacking Dopamine D2and D3Receptors Have Spatial Working Memory Deficits

2002 ◽  
Vol 22 (13) ◽  
pp. 5619-5629 ◽  
Author(s):  
Sara B. Glickstein ◽  
Patrick R. Hof ◽  
Claudia Schmauss
Keyword(s):  
Working Memory ◽  
Spatial Working Memory ◽  
Memory Deficits

Spatial working memory deficits and their relationship to negative symptoms in unmedicated schizophrenia patients

1996 ◽  
Vol 40 (9) ◽  
pp. 930-932 ◽  
Author(s):  
Cameron Carter ◽  
Lynn Robertson ◽  
Thomas Nordahl ◽  
Marc Chaderjian ◽  
Louis Kraft ◽  
...  
Keyword(s):  
Working Memory ◽  
Negative Symptoms ◽  
Spatial Working Memory ◽  
Memory Deficits

Structural correlates of spatial working memory deficits in schizophrenia

2000 ◽  
Vol 41 (1) ◽  
pp. 277-278
Author(s):  
T. Sigmundsson ◽  
J. Suckling ◽  
K. Greenwood ◽  
E.T. Bullmore ◽  
M. Maier ◽  
...  
Keyword(s):  
Working Memory ◽  
Spatial Working Memory ◽  
Memory Deficits

Spatial working memory deficits and clinical symptoms in schizophrenia: a 4-month follow-up study

1999 ◽  
Vol 46 (3) ◽  
pp. 392-400 ◽  
Author(s):  
Sohee Park ◽  
Jörg Püschel ◽  
Barbara H Sauter ◽  
Markus Rentsch ◽  
Daniel Hell
Keyword(s):  
Working Memory ◽  
Spatial Working Memory ◽  
Clinical Symptoms ◽  
Memory Deficits ◽  
Follow Up Study

Spatial working memory deficits and negative symptoms in schizophrenia

1995 ◽  
Vol 15 (1-2) ◽  
pp. 111
Author(s):  
C.S. Carter ◽  
L.C. Robertson ◽  
T.E. Nordahl ◽  
M. Chaderjian ◽  
L. Kraft ◽  
...  
Keyword(s):  
Working Memory ◽  
Negative Symptoms ◽  
Spatial Working Memory ◽  
Memory Deficits

scholarly journals Bacopa monnieri (L.) Wettst. Extract Improves Memory Performance via Promotion of Neurogenesis in the Hippocampal Dentate Gyrus of Adolescent Mice

2020 ◽  
Vol 21 (9) ◽  
pp. 3365 ◽  
Author(s):  
Hang Thi Nguyet Pham ◽  
Hong Nguyen Tran ◽  
Phuong Thi Nguyen ◽  
Xoan Thi Le ◽  
Khoi Minh Nguyen ◽  
...  
Keyword(s):  
Working Memory ◽  
Dentate Gyrus ◽  
Spatial Working Memory ◽  
Cell Damage ◽  
Bacopa Monnieri ◽  
Hippocampal Neurogenesis ◽  
Brdu Incorporation ◽  
Alcoholic Extract ◽  
Dependent Manner ◽  
Concentration Dependent Manner

Bacopa monnieri L. Wettst. (BM) is a botanical component of Ayurvedic medicines and of dietary supplements used worldwide for cognitive health and function. We previously reported that administration of BM alcoholic extract (BME) prevents trimethyltin (TMT)-induced cognitive deficits and hippocampal cell damage and promotes TMT-induced hippocampal neurogenesis. In this study, we demonstrate that administration of BME improves spatial working memory in adolescent (5-week- old) healthy mice but not adult (8-week-old) mice. Moreover, improved spatial working memory was retained even at 4 weeks after terminating 1-week treatment of adolescent mice. One-week BME treatment of adolescent mice significantly enhanced hippocampal BrdU incorporation and expression of genes involved in neurogenesis determined by RNAseq analysis. Cell death, as detected by histochemistry, appeared not to be significant. A significant increase in neurogenesis was observed in the dentate gyrus region 4 weeks after terminating 1-week treatment of adolescent mice with BME. Bacopaside I, an active component of BME, promoted the proliferation of neural progenitor cells in vitro in a concentration-dependent manner via the facilitation of the Akt and ERK1/2 signaling. These results suggest that BME enhances spatial working memory in healthy adolescent mice by promoting hippocampal neurogenesis and that the effects of BME are due, in significant amounts, to bacopaside I.

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