The modulation of action potential generation by calcium-induced calcium release is enhanced by mitochondrial inhibitors in mudpuppy parasympathetic neurons

Neuroscience ◽  
2004 ◽  
Vol 124 (2) ◽  
pp. 327-339 ◽  
Author(s):  
K.L Barstow ◽  
S.A Locknar ◽  
L.A Merriam ◽  
R.L Parsons
Keyword(s):  
Action Potential ◽  
Calcium Release ◽  
Action Potential Generation ◽  
Potential Generation ◽  
Mitochondrial Inhibitors ◽  
Parasympathetic Neurons ◽  
Calcium Induced Calcium Release

scholarly journals Calcium-induced calcium release regulates action potential generation in guinea-pig sympathetic neurones

2004 ◽  
Vol 555 (3) ◽  
pp. 627-635 ◽  
Author(s):  
Sarah A. Locknar ◽  
Karen L. Barstow ◽  
John D. Tompkins ◽  
Laura A. Merriam ◽  
Rodney L. Parsons
Keyword(s):  
Guinea Pig ◽  
Action Potential ◽  
Calcium Release ◽  
Action Potential Generation ◽  
Potential Generation ◽  
Sympathetic Neurones ◽  
Calcium Induced Calcium Release

scholarly journals Curbing action potential generation or ATP-synthase leads to a decrease in in-cell pyruvate dehydrogenase activity in rat cerebrum slices

2021 ◽  
Vol 11 (1) ◽  
Author(s):  
Benjamin Grieb ◽  
Sivaranjan Uppala ◽  
Gal Sapir ◽  
David Shaul ◽  
J. Moshe Gomori ◽  
...  
Keyword(s):  
Action Potential ◽  
Atp Synthase ◽  
Neural Activity ◽  
Pyruvate Dehydrogenase ◽  
Cerebral Metabolism ◽  
Neuronal Firing ◽  
Action Potential Generation ◽  
Potential Generation ◽  
Drastic Increase ◽  
Rat Cerebrum

AbstractDirect and real-time monitoring of cerebral metabolism exploiting the drastic increase in sensitivity of hyperpolarized 13C-labeled metabolites holds the potential to report on neural activity via in-cell metabolic indicators. Here, we followed the metabolic consequences of curbing action potential generation and ATP-synthase in rat cerebrum slices, induced by tetrodotoxin and oligomycin, respectively. The results suggest that pyruvate dehydrogenase (PDH) activity in the cerebrum is 4.4-fold higher when neuronal firing is unperturbed. The PDH activity was 7.4-fold reduced in the presence of oligomycin, and served as a pharmacological control for testing the ability to determine changes to PDH activity in viable cerebrum slices. These findings may open a path towards utilization of PDH activity, observed by magnetic resonance of hyperpolarized 13C-labeled pyruvate, as a reporter of neural activity.

Regulation of Axon Initial Segment Diameter by COUP-TFI Fine-tunes Action Potential Generation

2021 ◽  
Author(s):  
Xuanyuan Wu ◽  
Haixiang Li ◽  
Jiechang Huang ◽  
Mengqi Xu ◽  
Cheng Xiao ◽  
...  
Keyword(s):  
Action Potential ◽  
Initial Segment ◽  
Axon Initial Segment ◽  
Action Potential Generation ◽  
Potential Generation

Effect of Neuropeptide Y on Action Potential Generation in Working Cardiomyocytes of the Right Atrium in Rat Heart

2018 ◽  
Vol 165 (5) ◽  
pp. 610-612 ◽  
Author(s):  
A. A. Zverev ◽  
T. A. Anikina ◽  
N. G. Iskakov ◽  
A. L. Zefirov ◽  
T. L. Zefirov
Keyword(s):  
Action Potential ◽  
Neuropeptide Y ◽  
Right Atrium ◽  
Rat Heart ◽  
Action Potential Generation ◽  
Potential Generation ◽  
The Right

Sites of action potential generation in cultured vertebrate neurons

1983 ◽  
Vol 288 (1-2) ◽  
pp. 381-383 ◽  
Author(s):  
T.G. Smith
Keyword(s):  
Action Potential ◽  
Action Potential Generation ◽  
Potential Generation ◽  
Sites Of Action

Activation of axon initial segmental GABAA receptors inhibits action potential generation in neocortical GABAergic interneurons

2018 ◽  
Vol 138 ◽  
pp. 97-105 ◽  
Author(s):  
Yanbo Jiang ◽  
Yujie Xiao ◽  
Xiaoxue Zhang ◽  
Yousheng Shu
Keyword(s):  
Action Potential ◽  
Gabaa Receptors ◽  
Gabaergic Interneurons ◽  
Action Potential Generation ◽  
Potential Generation
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