Steady-state centrifugal input via the lateral olfactory tract modulates spontaneous activity in the rat main olfactory bulb

Neuroscience ◽  
2017 ◽  
Vol 348 ◽  
pp. 165-179
Author(s):  
Neil C. Ford ◽  
Edwin R. Griff
Keyword(s):  
Steady State ◽  
Olfactory Bulb ◽  
Spontaneous Activity ◽  
Main Olfactory Bulb ◽  
Lateral Olfactory Tract ◽  
Olfactory Tract

scholarly journals The Source of Spontaneous Activity in the Main Olfactory Bulb of the Rat

PLoS ONE ◽  
2011 ◽  
Vol 6 (8) ◽  
pp. e23990 ◽  
Author(s):  
Josif Stakic ◽  
Jessica M. Suchanek ◽  
Geoffrey P. Ziegler ◽  
Edwin R. Griff
Keyword(s):  
Olfactory Bulb ◽  
Spontaneous Activity ◽  
Main Olfactory Bulb

Abnormal Synaptic Transmission in the Olfactory Bulb of Fyn-Kinase–Deficient Mice

1998 ◽  
Vol 79 (1) ◽  
pp. 137-142 ◽  
Author(s):  
Hiromasa Kitazawa ◽  
Takeshi Yagi ◽  
Tsuyoshi Miyakawa ◽  
Hiroaki Niki ◽  
Nobufumi Kawai
Keyword(s):  
Olfactory Bulb ◽  
Synaptic Transmission ◽  
Metabotropic Glutamate Receptors ◽  
Granule Cells ◽  
Long Term Potentiation ◽  
Lateral Olfactory Tract ◽  
Metabotropic Glutamate ◽  
Olfactory Tract ◽  
Fyn Kinase ◽  
Deficient Mice

Kitazawa, Hiromasa, Takeshi Yagi, Tsuyoshi Miyakawa, Hiroaki Niki, and Nobufumi Kawai. Abnormal synaptic transmission in the olfactory bulb of Fyn-kinase–deficient mice. J. Neurophysiol. 79: 137–142, 1998. We studied synaptic transmission in the granule cells in the olfactory bulb of the homozygous Fyn (a nonreceptor type tyrosine kinase)-deficient ( fyn z/ fyn z) and heterozygous Fyn-deficient (+/ fyn z) mice by using slice preparations from the olfactory bulb. Stimulation to the lateral olfactory tract and/or centrifugal fibers to the olfactory bulb evoked field excitatory postsynaptic potentials (fEPSPs) in the granule cells. In +/ fyn z mice, fEPSPs were augmented by bicuculline, a γ-aminobutyric acid (GABAA) antagonist and picrotoxin, whereas fEPSPs in fyn z/ fyn z mice were much less sensitive to bicuculline and picrotoxin. Application of d-2-amino-5-phosphonopentanoic acid had no effect but 6-cyano-7-nitroquinoxaline-2,3-dione produced almost complete block of fEPSPs in both +/ fyn z mice and fyn z/ fyn z mice. (1S, 3R)-1-aminocyclo-pentane-1.3-dicarboxylate, an agonist of metabotropic glutamate receptors caused a similar depression of fEPSPs in both +/ fyn z and fyn z/ fyn z mice. In +/ fyn z mice tetanic stimulation to the lateral olfactory tract and/or centrifugal fibers induced N-methyl-d-aspartate (NMDA)-dependent long-term potentiation (LTP) of fEPSPs, whereas LTP was impaired in fyn z/ fyn z mice. Our results demonstrate altered functions of GABAA and NMDA receptors in the olfactory system of Fyn-deficient mice.

The Termination of Centrifugal Fibres in the Glomerular Layer of the Olfactory Bulb

1972 ◽  
Vol 10 (3) ◽  
pp. 621-635
Author(s):  
A. J. PINCHING ◽  
T. P. S. POWELL
Keyword(s):  
Electron Microscope ◽  
Olfactory Bulb ◽  
Mitral Cell ◽  
Lateral Olfactory Tract ◽  
Anterior Olfactory Nucleus ◽  
Axon Terminals ◽  
Glomerular Layer ◽  
Olfactory Tract ◽  
Functional Implications

The termination of the centrifugal fibres running in the lateral olfactory tract to the glomerular layer of the rat olfactory bulb has been determined with the electron microscope; this has been done with material perfused at various times after section of the lateral olfactory tract, as well as after a combination of this lesion with the long-term degeneration of olfactory nerves. The axon terminals are sparse at the glomerular level, but undergo typical degenerative changes; they are distributed solely in the periglomerular region and intermediate zone. The most common post-synaptic profiles are the processes of periglomerular cells, but a few centrifugal fibres terminate on short-axon, tufted and mitral cell dendrites. Evidence is produced to suggest that the anterior olfactory nucleus does not project as far as the glomerular layer. The findings are discussed in relation to previous studies with normal material and silver degeneration methods on similar experimental material; the functional implications of the centrifugal pathways in the bulb are briefly discussed.

Chronotopic organization of olfactory bulb axons in the lateral olfactory tract

2004 ◽  
Vol 475 (2) ◽  
pp. 247-260 ◽  
Author(s):  
Hitoshi Yamatani ◽  
Yasufumi Sato ◽  
Hajime Fujisawa ◽  
Tatsumi Hirata
Keyword(s):  
Olfactory Bulb ◽  
Lateral Olfactory Tract ◽  
Olfactory Tract

Alternating responses of olfactory bulb neurons to repetitive lateral olfactory tract stimulation

1977 ◽  
Vol 133 (1) ◽  
pp. 150-155 ◽  
Author(s):  
Kensaku Mori ◽  
Shinichi Kogure ◽  
Sadayuki F. Takagi
Keyword(s):  
Olfactory Bulb ◽  
Lateral Olfactory Tract ◽  
Olfactory Tract ◽  
Olfactory Bulb Neurons
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