Increased heartbeat-evoked potential during REM sleep in nightmare disorder

Abstract Sleep is a fundamental physiological state that facilitates neural recovery during periods of attenuated sensory processing. On the other hand, mammalian sleep is also characterized by the interplay between periods of increased sleep depth and environmental alertness. Whereas the heterogeneity of microstates during non-rapid-eye-movement (NREM) sleep was extensively studied in the last decades, transient microstates during REM sleep received less attention. REM sleep features two distinct microstates: phasic and tonic. Previous studies indicate that sensory processing is largely diminished during phasic REM periods, whereas environmental alertness is partially reinstated when the brain switches into tonic REM sleep. Here, we investigated interoceptive processing as quantified by the heartbeat evoked potential (HEP) during REM microstates. We contrasted the HEPs of phasic and tonic REM periods using two separate databases that included the nighttime polysomnographic recordings of healthy young individuals (N = 20 and N = 19). We find a differential HEP modulation of a late HEP component (after 500 ms post-R-peak) between tonic and phasic REM. Moreover, the late tonic HEP component resembled the HEP found in resting wakefulness. Our results indicate that interoception with respect to cardiac signals is not uniform across REM microstates, and suggest that interoceptive processing is partially reinstated during tonic REM periods. The analyses of the HEP during REM sleep may shed new light on the organization and putative function of REM microstates.

Download Full-text

Eye movements modulate interoceptive processing during rapid eye movement sleep: the heartbeat evoked potential in phasic and tonic REM microstates

10.31234/osf.io/vfdpz ◽

2020 ◽

Author(s):

Péter Simor ◽

Bogdány Tamás ◽

Robert Bodizs ◽

Pandelis Perakakis

Keyword(s):

Eye Movement ◽

Sensory Processing ◽

Rem Sleep ◽

Evoked Potential ◽

Physiological State ◽

Nrem Sleep ◽

Rapid Eye Movement ◽

Rapid Eye Movement Sleep ◽

Heartbeat Evoked Potential ◽

The Brain

Sleep is a fundamental physiological state that facilitates neural recovery during periods of attenuated sensory processing. On the other hand, mammalian sleep is also characterized by the interplay between periods of increased sleep depth and environmental alertness. Whereas the heterogeneity of microstates during non-rapid-eye-movement (NREM) sleep was extensively studied in the last decades, transient microstates during REM sleep received less attention. REM sleep features two distinct microstates: phasic and tonic. Previous studies indicate that sensory processing is largely diminished during phasic REM periods, whereas environmental alertness is partially reinstated when the brain switches into tonic REM sleep. Here, we investigated interoceptive processing as quantified by the heartbeat evoked potential (HEP) during REM microstates. We contrasted the HEPs of phasic and tonic REM periods using two separate databases that included the nighttime polysomnographic recordings of healthy young individuals (N = 20 and N = 19). We find a differential HEP modulation of a late HEP component (after 500 ms post-R-peak) between tonic and phasic REM. Moreover, the late tonic HEP component resembled the HEP found in resting wakefulness. Our results indicate that interoception with respect to cardiac signals is not uniform across REM microstates, and suggest that interoceptive processing is partially reinstated during tonic REM periods. The analyses of the HEP during REM sleep may shed new light on the organization and putative function of REM microstates.

Download Full-text

Focus of attention modulates the heartbeat evoked potential

NeuroImage ◽

10.1016/j.neuroimage.2018.11.037 ◽

2019 ◽

Vol 186 ◽

pp. 595-606 ◽

Cited By ~ 28

Author(s):

Frederike H. Petzschner ◽

Lilian A. Weber ◽

Katharina V. Wellstein ◽

Gina Paolini ◽

Cao Tri Do ◽

...

Keyword(s):

Evoked Potential ◽

Focus Of Attention ◽

Heartbeat Evoked Potential

Download Full-text

Effect of heartbeat perception on heartbeat evoked potential waves

Neuroscience Bulletin ◽

10.1007/s12264-007-0053-7 ◽

2007 ◽

Vol 23 (6) ◽

pp. 357-362 ◽

Cited By ~ 26

Author(s):

Hui Yuan ◽

Hong-Mei Yan ◽

Xiao-Gang Xu ◽

Fei Han ◽

Qing Yan

Keyword(s):

Evoked Potential ◽

Heartbeat Perception ◽

Heartbeat Evoked Potential

Download Full-text

Altered Interoceptive Processing in Generalized Anxiety Disorder—A Heartbeat-Evoked Potential Research

Frontiers in Psychiatry ◽

10.3389/fpsyt.2019.00616 ◽

2019 ◽

Vol 10 ◽

Cited By ~ 7

Author(s):

Jiaoyan Pang ◽

Xiaochen Tang ◽

Hui Li ◽

Qiang Hu ◽

Huiru Cui ◽

...

Keyword(s):

Anxiety Disorder ◽

Generalized Anxiety Disorder ◽

Evoked Potential ◽

Generalized Anxiety ◽

Heartbeat Evoked Potential

Download Full-text

Dynamic neurocognitive changes in interoception after heart transplant

Brain Communications ◽

10.1093/braincomms/fcaa095 ◽

2020 ◽

Vol 2 (2) ◽

Cited By ~ 1

Author(s):

Paula Celeste Salamone ◽

Lucas Sedeño ◽

Agustina Legaz ◽

Tristán Bekinschtein ◽

Miguel Martorell ◽

...

Keyword(s):

Longitudinal Study ◽

Heart Transplant ◽

Evoked Potential ◽

Detection Task ◽

Event Related Potential ◽

Healthy Controls ◽

Heart Transplants ◽

Post Transplant ◽

Heartbeat Evoked Potential

Abstract Heart–brain integration dynamics are critical for interoception (i.e. the sensing of body signals). In this unprecedented longitudinal study, we assessed neurocognitive markers of interoception in patients who underwent orthotopic heart transplants and matched healthy controls. Patients were assessed longitudinally before surgery (T1), a few months later (T2) and a year after (T3). We assessed behavioural (heartbeat detection) and electrophysiological (heartbeat evoked potential) markers of interoception. Heartbeat detection task revealed that pre-surgery (T1) interoception was similar between patients and controls. However, patients were outperformed by controls after heart transplant (T2), but no such differences were observed in the follow-up analysis (T3). Neurophysiologically, although heartbeat evoked potential analyses revealed no differences between groups before the surgery (T1), reduced amplitudes of this event-related potential were found for the patients in the two post-transplant stages (T2, T3). All these significant effects persisted after covariation with different cardiological measures. In sum, this study brings new insights into the adaptive properties of brain–heart pathways.

Download Full-text